Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Comparative clinicogenetic study of schizophrenic psychoses

The author diagnoses 350 carefully selected schizophrenic subjects, their parents and their siblings during parallel studies using three different clinical classification systems and analyzes the results by multiple threshold analysis and the multifactorial inheritance model. The results suggest that, of the three classifications the author studied, Leonhard's and Sneshnewski's system yield relatively homogeneous subgroups; this indicates the future significance of these nosological systems for the planning of biopsychiatric research.     

Compliance with homework to employ self-instructions in controlling ice water pain: an analogue to counseling

40 women were taught to use self-statements to cope with pain caused by ice water. The trainer used four different strategies for reassigning a homework task of using self-statements to cope with pain produced by immersing one hand in ice water. The strategies were equally effective in eliciting compliance with the homework assignment.     

The horizontal-vertical illusion in photographs of concrete scenes with and without depth information

On the basis of the hypothesis of misapplied constancy scaling, the perception of an abstract horizontal-vertical illusion figure embedded in photographs of natural scenes with depth cues is investigated. The effect is compared with that of a figure on photographs containing no depth information and with a figure on a neutral surface. It is shown that the magnitude of the illusion in the perspective scenes is greater than in the other two conditions. The results are considered compatible with a constancy theory of the illusion. Finally, the evidence for misapplied constancy scaling in the horizontal-vertical illusion in relation to a retinal theory is discussed.     

Auditory-successive selective attention for learning disabled and normal boys

Improvement in auditory-successive selective attention was noted across the age range of 9 through 16 yr. In contrast to comparable paradigms with visual-simultaneous materials, 30 learning disabled and 30 normal boys did not differ. Results of research on selective attention may be affected by task materials and encoding requirements.     

Psychometric studies on the specificity of psychological performance disorders of epileptic patients

Using a psychological test battery for registration of psychic/psychomotoric speed and flexibility/perseveration we examined 78 epileptic patients with different forms of epilepsy and the same number of brain healthy control persons, parallelised in sex, age, education, profession and intelligence. The registrated data were varianz-, correlation- and factoranalised. We found a deceleration of psychic/psychomotoric speed as a primary basic disorder in epileptics. Decreases of flexibility independent of speed were not ascertainable.