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Most studies of suicide in younger patients have demonstrated significant alterations in the serotonin system. Although a high percentage of completed suicides occur in late-life, to date very few studies of the biology of suicide have focused on this age group. This chapter describes age-related changes in the central nervous system pertinent to the biology of suicide, then reviews post-mortem biological studies of the brains of suicides and suicide attempters. As suicide attempts in the elderly are characterized by the use of violent means, biologic studies of impulsive violence are discussed. Finally we describe data on the effect of degenerative diseases on the serotonin system and the possible link to increased suicidal behavior in affected patients. This review underscores the need for further study of the biology of suicide in the geriatric age group.  相似文献   
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It is widely assumed that reinforcers are biologically relevant stimuli, or stimuli that have been associated with biologically relevant stimuli. However, brief, arbitrary stimuli have also been reported to have reinforcement-like effects, despite being unrelated to biologically relevant stimuli like food. The present study explored the potential reinforcement-like effects of brief stimuli across 5 experiments. In Experiments 1 through 4, pigeon subjects responded for food reinforcement and brief stimulus presentations in a 2-component multiple schedule. Neither baseline response rates nor resistance to change during disruption tests were systematically greater in a component with versus without brief stimulus presentations. Increasing the rate and duration of brief stimulus presentations in Experiment 4 did not reveal reinforcement-like effects when compared directly with food. In Experiment 5, pigeons chose between independent terminal links in a concurrent-chains procedure. Across conditions, varying the location, duration, and rate of brief stimulus presentations in the terminal links had no systematic effects on preference. In contrast, varying rates of food reinforcers resulted in large and reliable shifts in preference. Therefore, the present study found no systematic evidence that brief stimuli unrelated to food reliably increase response rates, resistance to change, or preference. These data demonstrate the value of systematic replication, and a behavioral momentum approach to assessing potential reinforcement-like effects.  相似文献   
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Subjects in five experiments read nine-digit memory lists from a cathode ray tube for immediate recall. Reading aloud always produced a localized and reliable advantage for the last item, compared to reading silently. Two experiments on whispered and mouthed lists, with or without simultaneous broadband noise, falsified expectations derived from the theory of precategorical acoustic storage. Three additional experiments showed no enhancement of recency in the silent conditions when the digits were drawn or spelled gradually on the screen, a result that is inconsistent with the changing-state hypothesis. The classic auditory-visual modality effect is large and reliable, but still poorly understood.  相似文献   
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Early explications of family communication patterns (FCP) suggested that a family's communication pattern arises as a result of interactions in which parents and adolescents influence each other. In contrast, empirical research usually treats FCP as parent‐imposed norms that influence socialization outcomes in adolescents, without testing whether adolescents' socialization influences FCP. This study revisits the assumption that adolescents influence FCP, using data from a longitudinal quasi‐experimental evaluation of a school‐based civics curriculum intervention (N = 313 parent‐adolescent pairs). Results show that the intervention‐stimulated adolescents to initiate discussion of politics at home and that these adolescent‐initiated discussions influenced adolescents' and parents' perceptions of FCP 6 months later.  相似文献   
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In three experiments we studied the relationship between contextual conditioning and the reinstatement of extinguished lever pressing that occurs when noncontingent food is introduced following extinction. In all three experiments the non-contingent food was presented off-baseline (with the response levers not present). On subsequent tests, with the response levers present, animals that had been exposed to food showed more reinstatement of lever pressing than control animals. This finding rules out alternative mechanisms for the reinstated responding that rely on the interaction of non-contingent food and responding, such as superstitious reinforcement or the discriminative after-effects of food. In addition, in each experiment we demonstrated that manipulations known to affect contextual conditioning (signalling the food in Experiment 1, context extinction in Experiment 2, and switching contexts in Experiment 3) reduced the reinstatement. These results are consistent with the claim that contextual conditioning is important in controlling instrumental conditioning and closely parallel findings concerning the reinstatement of Pavlovian responsing following extinction.  相似文献   
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