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261.
Sprague-Dawley rats drank sweetened (3% dextrose + 0.144% saccharin, w/v) or unflavored water for 18 days and subsequent pain reactivity was assessed using a hot plate. Compared to the rats that consumed unflavored water, the rats that consumed sweet water responded more quickly on the hot plate indicating that their threshold for pain was lowered. Another group of rats given identical exposure to the fluids had their brains prepared for measuring opiate receptor binding using the delta-receptor ligand [3H]D-Ala-D-Leu-enkephalin ([3H]DADLE) and the mu-receptor selective ligand [3H]Tyr-D-Ala-Gly-MePhe-Gly-ol ([ 3H]DAGO). Binding of these opiates to mu- and delta-receptors in the cerebral cortex, striatum, hippocampus, hypothalamus, brain stem, and remaining brain regions was the same for the rats that drank sweet fluids and those that drank unflavored water. These findings suggest that drinking sweet fluids lowers pain thresholds but does not alter mu- and delta-receptors. 相似文献
262.
After thermal cauterization of the area postrema in rats the absence of conditioned taste aversion to sucrose paired with lithium chloride (0.15 M, 3.3 ml/kg) was used as a pharmacologic/behavioral index of area postrema damage. In a subsequent experiment the effects of area postrema lesions on three measures proposed as species-relevant measures of motion sickness were studied, using off-vertical rotation at 150 degrees/s for either 30 or 90 min. Lesions of area postrema did not alter postrotational suppression of drinking or amount of defecation during motion. The initial acquisition of conditioned taste aversion to a novel cider vinegar solution paired with motion was not affected by lesioning of the area postrema, but these taste aversions extinguished more slowly in lesioned rats than in sham-operates or intact controls. Results are discussed in terms of proposed humoral factors which may induce motion sickness and in light of recent data on the role of the area postrema in similar measures in species possessing the complete emetic reflex. 相似文献
263.
Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats 总被引:1,自引:0,他引:1
E D Levin 《Behavioral and neural biology》1988,50(2):240-245
Recent evidence indicates that acetylcholine and dopamine play complementary roles in cognitive as well as motor functions. In our previous study, the dopamine receptor blocker, haloperidol, was found to attenuate the radial-arm maze choice accuracy deficit caused by the muscarinic acetylcholine receptor blocker, scopolamine. Haloperidol has activity in blocking both D1 and D2 dopamine receptor subtypes. The current study was conducted to determine whether this dopamine-acetylcholine interaction specifically involved D1 or D2 dopamine receptors. The D1 antagonist, SCH 23390, and the D2 antagonist, raclopride, were administered with a dose of scopolamine which caused choice accuracy deficits in the radial-arm maze. The scopolamine-induced deficit was reversed by SCH 23390, the D1 antagonist, indicating that D1 blockade alone is sufficient to reverse the amnestic effects of muscarinic blockade. There was no indication in this study that the D2 blocker, raclopride, had a similar effect. However, this does not mean that such an effect may not be present at other doses of raclopride or with other D2 antagonists. The present finding that D1 blockade counteracts scopolamine-induced cognitive dysfunction not only furthers the understanding of dopamine-acetylcholine relationships in cognitive function, it also suggests a promising direction for the development of treatments for cognitive dysfunction due to cholinergic loss. 相似文献
264.
Interactions between area and numerosity 总被引:2,自引:0,他引:2
Piet G. Vos Michiel P. van Oeffelen Hein J. Tibosch Jüri Allik 《Psychological research》1988,50(3):148-154
Summary The concept of filled area, i.e. the impressionistic ensemble of parts of a stimulus field occupied by dots, is used to account for various kinds of numerosity illusions due to perceptual interaction between a number of dots and their spatial arrangement. A measure of filled area is derived from a model for the perceptual clustering of dots on the basis of relative proximity. It is shown that the quantified concept of filled area successfully predicts illusion data from earlier studies. Subsequently, a two-alternatives forced-choice numerosity experiment is reported, the data of which gave further evidence of the predictive power of the filled-area hypothesis. Our approach is discussed with respect to spatial features of dot stimuli that might be in rivalry with the filled-area factor in numerosity-estimation tasks. 相似文献
265.
Summary The interactive-activation model postulates (a) that activation at the letter level leads automatically to activation at the word level, (b) that the word-superiority effect reflects reactivation of letters by the word they spell, and (c) that subjects identify words on the basis of information obtained from separate letter-position channels. In the first two experiments, we showed words in upper, lower, or mixed case: the word-superiority effect was reduced when words were presented in mixed-case letters, presumably because extra-letter information is lost with mixed-case presentation; i.e., postulate (c) is wrong. The third experiment showed that when the letters of a word are rotated 180° subjects can identify the letters without producing a word-superiority effect; i.e., one of postulates (a) and (b) is wrong. In Experiments 4 and 5, we trained subjects to name words presented in inverted letters; training was more effective when subjects could exploit bigram information in addition to letter-channel information; i.e., reading inverted text is based on extra-letter-feature information, not on a general skill in rotating letters. Taken together, our data deny three of the interactive-activation model's major postulates. We offer some suggestions for future versions of the model.
Electronic mail: Userid: MEWHORTD; Nodeid: QUCDN; Domain: BITNET 相似文献
266.
The present study examined the effect of facial attractiveness and gender on raters' evaluations of and explanations for managerial performance. Results showed attractiveness to be a potential liability for both males and females. Good performance of attractive females was more likely than that of others to be attributed to luck or bias, while that of attractive males was viewed as occurring with little effort. In addition, the poor performance of attractive individuals was blamed on lack of effort (females) or lack of ability (males). Implications of these findings are discussed.An earlier version of this paper was published in the 1986 Proceedings of the Southern Management Association. 相似文献
267.
Twenty trainees and 18 partners took part in a study of the effects of a marriage guidance training programme on their own marriage. Changes were assessed in two ways: retrospectively ('perceived' changes as assessed following training) and prospectively (changes calculated by comparing scores obtained before training and those obtained after training). For most dimensions there was little correspondence between 'perceived' change and 'calculated' change. This has important methodological implications, which are discussed. The 'calculated' change indicated poorer marital adjustment following training. The trainees' scores suggested that they had become less 'abasing' and less 'nurturant' towards their partners; also that they had more disagreements about 'philosophy of life' and 'dealing with in-laws'. Their comments suggested that a number of the trainees had become more analytical of their own marriages, and that training had heightened their awareness of their own needs and individuality. 相似文献
268.
269.
Bernard E. Whitley Jr. 《Sex roles》1988,19(9-10):619-638
This study examined the relations of gender and three aspects of gender roles — self concept, behavior, and sexual attitudes — to three aspects of sexual behavior — sexual experience, reasons for intercourse, and contraceptive use. Gender was strongly related to all three aspects of sexual behavior. For both men and women, sex role behaviors were related to sexual experience and to reasons for intercourse, but not to contraceptive use, and sex role self-concept was unrelated to any of the aspects of sexual behavior. The results indicate that sexual behavior is influenced both by societal gender role norms and by individual differences in the acceptance of those norms. 相似文献
270.
G M Harrington 《Journal of comparative psychology (Washington, D.C. : 1983)》1988,102(4):400-407
Controversy abounds over attributing group differences on tests to nature, nurture, or test bias. Limitations of correlational sampling from natural populations necessitate experimental methods to resolve underlying issues. In classical psychometrics test items are selected from a larger item pool through analysis of item responses in a sample of subjects. Rats of six inbred strains (n = 366) were tested in multiple mazes to provide a large item pool. Six populations were created, each with differing proportions of each strain. Items selected through independent item analyses within each population yielded six tests. An independent cross-validation sample (n = 146) provided scores on all six tests. This sample was also tested in another set of maze problems defined as the criterion to be predicted. Strain means and intrastrain predictive validities for the six tests varied with strain representation in the population used for item selection (p less than .001). Conventional item-selection procedures clearly produced two forms of minority test bias. 相似文献