Determination of dipeptidyl aminopeptidase activities in the cerebrospinal fluid

The investigation of enzyme activity in cerebrospinal fluid has been without relevant results for laboratories analysing spinal fluid. For neurochemical purposes, it is interesting that the Substance P is convered by Depeptidyl-aminopeptidase IV (DP IV), liberating dipeptides. The hydrolysis of nitroanilids of the form Xaa-Pro-NHNp in cerebrospinal fluid was analysed using them as peptidases substrates. Finally a method for measuring the activity was proposed.     

On tests for correlated proportions in the presence of incomplete data

This paper proposes test statistics based on the likelihood ratio principle for testing equality of proportions in correlated data with additional incomplete samples. Powers of these tests are compared through Monte Carlo simulation with those of tests proposed recently by Ekbohm (based on an unbiased estimator) and Campbell (based on a Pearson-Chi-squared type statistic). Even though tests based on the maximum likelihood principle are theoretically expected to be superior to others, at least asymptotically, results from our simulations show that the gain in power could only be slight.     

Depressed mood and environmental mastery as potential pathways linking family relationship quality and disease self-management for African Americans with hypertension

African Americans are at significantly greater risk of hypertension and worse cardiovascular outcomes than other racialized groups, yet hypertension intervention effects remain limited. Thus, it is necessary to understand the potential mechanisms whereby interventions may be more effectively targeted to improve health. Supported by prior research evidence and guided by the Biobehavioral Family Model, this study examined associations between family relationship quality, psychological wellbeing, and self-management behaviors for African Americans with hypertension. Data were pooled from three Midlife Development in the U.S. projects, resulting in a sample of 317 African Americans (63.4% female, M_age = 53.32) with self-reported high blood pressure in the past 12 months. We tested four cross-sectional multiple mediator models, with depressed mood and environmental mastery mediating associations between family strain and exercise, smoking, problematic alcohol use, and stress-eating. Environmental mastery mediated the association between greater family strain and decreased odds of achieving recommended exercise levels; greater odds of reporting problematic alcohol use; and greater stress-eating. Though family strain was associated with depressed mood in each model, this variable did not serve as an indirect pathway to self-management behaviors. Family strain, and the potential pathway identified via environmental mastery, may be a meaningful predictor of disease self-management for African Americans with hypertension. Longitudinal studies are needed to examine directionality and to support intervention trials for improving self-management and hypertension outcomes.     

Analysis of Religious Bias among Christian Students in Science

Christians are notably underrepresented in science in part due to long-standing public perceptions of science-religion incompatibility and antireligious bias in science. This research explores whether undergraduates at a Christian university perceive and impose anti-Christian cultural stigma in science. Survey results from 126 biology students revealed that though students generally perceived the culture of science to be anti-Christian, they perceived Christians to have equal opportunities for scientific achievement. Results from a quasi-experimental audit study, in which students evaluated one of two profiles for mock prospective Ph.D. applicants (Christian or undisclosed faith) showed that students did not project anti-Christian stereotypes in terms of competence, hireability, or likeability, but showed some evidence of pro-Christian favorability. Together, this study suggests that the affirmational community of a Christian University may alleviate some negative impacts of anti-Christian stereotypes in academic biology, even as students perceive discrimination against Christians in science and atheists as more scientifically competent.     

Take care of egotism,and redemption will take care of itself: Comments on Tracy Llanera's Richard Rorty: Outgrowing modern nihilism

This commentary critically examines two facets of Tracy Llanera's recent book Richard Rorty: Outgrowing Modern Nihilism. First, it considers her interpretation of Richard Rorty's redemptive project. It argues that, while Llanera succeeds in resolving tensions in Rorty's public-private distinction, her account downplays the role of abnormal discourse within projects of self-creation. Second, it raises several questions about Llanera's strategy for situating this redemptive project within debates concerning existential nihilism. On her view, one ought to follow Rorty in addressing the problem of egotism instead of the problem of nihilism, since the former is prior to the latter. But it is not clear who counts as an egotist, or why egotists are especially prone to becoming nihilists. Moreover, there are reasons to think that egotism and nihilism are fundamentally different kinds of problems.