Frontal pole cortex: encoding ends at the end of the endbrain

Considerable neuroimaging research in humans indicates that the frontal pole cortex (FPC), also known as Brodmann area 10, contributes to many aspects of cognition. Despite these findings, however, its fundamental function and mechanism remain unclear. Recent neurophysiological results from the FPC of monkeys have implications about both. Neurons in the FPC seem to encode chosen goals at feedback time and nothing else. Goals, the places and objects that serve as targets for action, come in many forms and arise from many cognitive processes. The FPC's signal, although surprisingly simple for neurons at the apex of a prefrontal hierarchy, could promote learning about which kinds of goals and goal-generating processes produce particular costs and benefits, thereby improving future choices.     

Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors

In hippocampal CA1 neurons of wild-type mice, delivery of a standard tetanus (100 pulses at 100 Hz) or a train of low-frequency stimuli (LFS; 1000 pulses at 1 Hz) to a naive input pathway induces, respectively, long-term potentiation (LTP) or long-term depression (LTD) of responses, and delivery of LFS 60 min after tetanus results in reversal of LTP (depotentiation, DP), while LFS applied 60 min before tetanus suppresses LTP induction (LTP suppression). To evaluate the role of the type 1 inositol-1,4,5-trisphosphate receptor (IP3R1) in hippocampal synaptic plasticity, we studied LTP, LTD, DP, and LTP suppression of the field excitatory postsynaptic potentials (EPSPs) in the CA1 neurons of mice lacking the IP3R1. No differences were seen between mutant and wild-type mice in terms of the mean magnitude of the LTP or LTD induced by a standard tetanus or LFS. However, the mean magnitude of the LTP induced by a short tetanus (10 pulses at 100 Hz) was significantly greater in mutant mice than in wild-type mice. In addition, DP or LTP suppression was attenuated in the mutant mice, the mean magnitude of the responses after delivery of LFS or tetanus being significantly greater than in wild-type mice. These results suggest that, in hippocampal CA1 neurons, the IP3R1 is involved in LTP, DP, and LTP suppression but is not essential for LTD. The facilitation of LTP induction and attenuation of DP and LTP suppression seen in mice lacking the IP3R1 indicates that this receptor plays an important role in blocking synaptic potentiation in hippocampal CA1 neurons.     

The procerebrum is necessary for odor-aversion learning in the terrestrial slug Limax valentianus

The terrestrial slug Limax has a highly developed ability to associate the odor of some foods (e.g., carrot juice) with aversive stimuli such as the bitter taste of quinidine solution. The procerebrum (PC) is a part of the slug's brain thought to be involved in odor-aversion learning, but direct evidence is still lacking. Here we present evidence showing that the PC is essential for odor-aversion learning. Unlike sham-operated slugs, PC ablation 7 d prior to conditioning showed that most slugs did not avoid carrot juice in the memory retention test conducted 24 h after the conditioning. Slugs with the PC ablated 3 h, 1 d, 3 d, or 7 d after conditioning and examined by the memory retention test at 3 d after the PC ablation were also less likely to avoid carrot juice than sham-operated slugs. The PC ablation did not damage the ability of the slugs to sense attractive odor (everyday food) or innately aversive odor (onion or garlic). These results demonstrate that the PC is a necessary component in the retention and/or retrieval of odor-aversion memory.     

Depletion of serotonin selectively impairs short-term memory without affecting long-term memory in odor learning in the terrestrial slug Limax valentianus

The terrestrial slug Limax is able to acquire short-term and long-term memories during aversive odor-taste associative learning. We investigated the effect of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on memory. Behavioral studies indicated that 5,7-DHT impaired short-term memory but not long-term memory. HPLC (high-performance liquid chromatography) analysis revealed that 5,7-DHT significantly reduced serotonin content in the central nervous system. The present study suggests that acquisition, retention, and/or retrieval of short-term memory involves serotonin, and neither acquisition nor retrieval of long-term memory requires serotonin at a level as high as that required for short-term memory.     

Hemispheric asymmetry in a perceptual priming task: evidence from patients with unilateral brain damage.

The present study examined the relationship between unilateral brain damage and the effect of nonverbal perceptual priming using a picture-fragment completion task. Subjects consisted of 11 left brain-damaged patients, 8 right brain-damaged patients, and 10 healthy normal controls. The mean score of normal controls was significantly higher than those of left and right brain-damaged patients. Although there were significant effects of priming in all the groups, a significant difference in amplitude of priming effects was found only between right brain-damaged patients and normal controls. The correlation between amount of fragmentation at which there was identification and priming effect was not significant. We conclude that the right hemisphere is more involved in perceptual priming of form than is the left hemisphere, and form-dependent processing in the perceptual priming task has an asymmetrical distribution in the right and left hemispheres.     

Why is intelligence associated with stability of happiness?

In the National Child Development Study, life‐course variability in happiness over 18 years was significantly negatively associated with its mean level (happier individuals were more stable in their happiness, and it was not due to the ceiling effect), as well as childhood general intelligence and all Big Five personality factors (except for Agreeableness). In a multiple regression analysis, childhood general intelligence was the strongest predictor of life‐course variability in life satisfaction, stronger than all Big Five personality factors, including Emotional stability. More intelligent individuals were significantly more stable in their happiness, and it was not entirely because: (1) they were more educated and wealthier (even though they were); (2) they were healthier (even though they were); (3) they were more stable in their marital status (even though they were); (4) they were happier (even though they were); (5) they were better able to assess their own happiness accurately (even though they were); or (6) they were better able to recall their previous responses more accurately or they were more honest in their survey responses (even though they were both). While I could exclude all of these alternative explanations, it ultimately remained unclear why more intelligent individuals were more stable in their happiness.     

The Effects of Self-Construals and Interactive Constraints on Consumer Complaint Behaviors Across Cultures

This study predicts cross-cultural associations between task and face constraints in relation to consumer complaint behaviors. Participants comprised 1200 undergraduates from Kyoto City in Japan and 420 undergraduates from Las Vegas and Tennessee in the USA. The complaint methods studied include direct voice responses, private responses (negative word of mouth and exit action), and third-party responses. We found that complaints are usually made when service failures occur at the level of co-consumption, rather than at the level of the unaccompanied consumer. The results elucidate intrapersonal and interpersonal views regarding the role played by task constraints and face constraints in mediating the relationship between independent and interdependent self-construals and complaints expressed in various ways. Discussion of these results and their implications is provided, followed by suggestions for future research on culture and conversational constraints (task and face constraints), which leads to complaint behavior, and implications of such research.     

In-situ X-ray diffraction during tensile deformation of ultrafine-grained copper using synchrotron radiation

At the synchrotron facility, Super Photon Ring – 8 GeV, in-situ X-ray diffraction during tensile deformation was conducted on ultrafine-grained Cu with a grain size of about 300 nm fabricated by equal-channel angular pressing. The diffraction profile was observed with the time resolution of about 1 s using multiple MYTHEN detectors, and the diffraction angle and the full-width at half-maximum of some Bragg peaks were determined using the pseudo-Voigt function. From the analysis of Bragg peaks, it was found out that there are microscopically three regions; elastic, plastic and transition regions. The 0.2% proof stress obtained from the stress–strain curve locates within the microscopic transition region. Microstrain was evaluated using the Williamson–Hall method and the dislocation density was also obtained from the microstrain. The dislocation density starts increasing before 0.2% proof stress, which is associated with dislocation bow-out and emission from grain boundaries. The Taylor relationship seems to be still satisfied after 0.2% proof stress.     

The Treatment of Anxiety in Autism Spectrum Disorder (TAASD) Study: Rationale,Design and Methods

This paper describes the rationale, design, and methods of the Treatment for Anxiety in Autism Spectrum Disorders study, a three-site randomized controlled trial investigating the relative efficacy of a modular CBT protocol for anxiety in ASD (Behavioral Interventions for Anxiety in Children with Autism) versus standard CBT for pediatric anxiety (the Coping Cat program) and a treatment-as-usual control. The trial is distinct in its scope, its direct comparison of active treatments for anxiety in ASD, and its comprehensive approach to assessing anxiety difficulties in youth with ASD. The trial will evaluate the relative benefits of CBT for children with ASD and investigate potential moderators (ASD severity, anxiety presentation, comorbidity) and mediators of treatment response, essential steps for future dissemination and implementation.     

Women's Psychological Experiences in a Narrative Therapy-Based Group: An Analysis of Participants' Writings and Beck Depression Inventory–Second Edition

The purpose of this study was to explore women's experiences in a narrative therapy-based group conducted to help participants re-author their stories. Seven women who were either patients or individuals enrolled in Transition Support for Employment at a psychiatric clinic participated in the meetings, one every fortnight. Each session explored a theme based on narrative therapy techniques such as externalization. The participants wrote their reflections during each session, and completed the Beck Depression Inventory-Second Edition (BDI-II) during the initial and final sessions. An affinity diagram was developed to classify their written reflections into 22 lower categories (e.g., new understanding of self, forward-looking-understanding of life) and 4 upper categories (“Insight,” “Sharing with others,” “Changes with understanding of lives,” “Higher motivation”). The relationship among five lower categories comprising “Insight” was explored, and it became apparent that clarification of participants' own thoughts about social problems functioned as a mediator promoting the process. The largest portion of depressed feelings emerged during the initial session, and four participants had lower scores for BDI-II items such as self-criticism in the final session. The results suggest that the group's purpose was realized. However, future studies should examine participants' feelings more closely, especially during the initial session.