Predictive genetic testing for conditions that present in childhood

There is a general consensus in the medical and medical ethics communities against predictive genetic testing of children for late onset conditions, but minimal consideration is given to predictive testing of asymptomatic children for disorders that present later in childhood when presymptomatic treatment cannot influence the course of the disease. In this paper, I examine the question of whether it is ethical to perform predictive testing and screening of newborns and young children for conditions that present later in childhood. I consider the risks and benefits of (1) predictive testing of children from high-risk families; (2) predictive population screening for conditions that are untreatable; and (3) predictive population screening for conditions in which the efficacy of presymptomatic treatment is equivocal. I conclude in favor of parental discretion for predictive genetic testing, but against state-sponsored predictive screening for conditions that do not fulfill public health screening criteria.     

Spatial location judgments: a cross-national comparison of estimation bias in subjective North American geography

We examined alternate explanations for distortions in the subjective representation of North American geography. One explanation, based on physical proximity, predicts that bias in location estimates should increase with the distance from a participant's home city or region. An alternative is that biases arise from combining accurate and inaccurate beliefs about the cities and the superordinate regions to which they belong, including beliefs that may have social or cultural origins. To distinguish these, Canadians from Alberta and Americans from Texas judged the latitudes of cities in Canada, the U.S., and Mexico. The Texans' estimates of Mexican locations were 16" (approximately 1,120 miles) more biased than their estimates of Canadian locations that were actually about 840 miles farther away. This finding eliminates proximity as a primary source of geographic biases and underscores the role of categorical beliefs as an important source of biased judgments.     

The impact of conflict of interest on trust in science

Conflicts of interest have an erosive effect on trust in science, damaging first the attitude of the public toward scientists and their research, but also weakening the trusting interdependence of scientists. Disclosure is recognized as the key tool for management of conflicts, but rules with sanctions must be improved, new techniques for avoidance of financial conflicts by alternative funding of evaluative research must be sought, and there must be new thinking about institutional conflicts of interest. Our profession is education, and both the public and research professionals of all ages would benefit from greater understanding of how science should and does work. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

Are The Very Happy Too Happy?

Although positive emotions undoubtedly confer benefits, one can have too much of it. There is probably a point beyond which enjoyment interferes with realism, yet it is unclear where that point is. The original States of Mind (SOM) model (Schwartz and Garamoni, 1986; 1989) proposed that a ratio of [positive] to [positive plus negative] affective/cognitive states [P/(P+N)] of about 0.62 is optimal, but previous research indicated that higher ratios may go with good mental health. The revised balanced states of mind (BSOM) model (Schwartz, 1997) suggests a higher cutoff, with ratios above 0.90 being dysfunctional. This paper reports a study of 72 very positive subjects (mean ratio = 0.85) and assessed possible dysfunction by means of questionnaires, role-plays, and physiological responses to induced stress. Signs of dysfunction were no more frequent among the most positive subjects (ratios of 0.90 and above) than among moderately positive subjects. This suggests that there is nothing wrong with the high levels of happiness in present day society. As yet, it is still not established how much more happiness will be too much. One possibility is that standard cognition/emotion measures need to be revised in order to detect truly excessive positivity in a sensitive manner.     

The Penn Psychoanalytic Treatment Collection: a set of complete and recorded psychoanalyses as a research resource

From a set of seventeen complete and tape-recorded psychoanalyses, a sample of findings is presented: (a) the level of agreement of two clinical judges on the psychological health of these patients is adequate for the late sessions, but not for the early sessions; (b) the amount of change during psychoanalysis appears to be similar to that in the Menninger Foundation Psychotherapy Research Project; (c) psychiatric severity measures from the early sessions can yield a significant level of prediction of the later benefits from psychoanalysis. Finally, further research uses of this collection of psychoanalyses are suggested.     

Predicting memory benefits in the production effect: the use and misuse of self-generated distinctive cues when making judgments of learning

The production effect occurs when reading a word aloud leads to better memory for the item, relative to words that are read silently. In the present study, we assessed the degree to which judgments of learning (JOLs) are sensitive to the production effect, to determine whether people are aware of how distinctive cues can enhance memory. If the act of saying a word aloud is used as a cue for later memorability, then JOLs should be sensitive to production. Experiment 1 demonstrated that this was the case, as participants provided higher JOLs for produced items than for those read silently. This pattern of JOLs was also evident when participants silently mouthed words (Exp. 2). In Experiment 3, participants instead made a nonunique response as the production component (saying “yes” instead of the word itself). JOLs were still higher under production, although memory performance did not differ from that in a silent condition. The results suggest that the presence of both specific and nonspecific self-generated cues is used to make metacognitive judgments, likely due to the high accessibility of this information, but that participants are not precisely aware of how distinctiveness enhances encoding and retrieval. Such findings have implications for how distinctiveness is perceived by learners and for what cues would appropriately be incorporated when predicting future memory performance.     

Genetic and environmental influences on rumination and its covariation with depression

This study examined the extent to which rumination and depression share genetic and environmental influences in a community sample of adult twins (N = 663). Twins completed multiple rumination questionnaires, a depressive symptoms questionnaire and a diagnostic interview. Rumination was moderately heritable (h² = .37–.41 for the latent variable) and substantially influenced by nonshared environmental factors, and these results were consistent across different measures. Nonshared environmental influences on rumination were larger for women than men. Depressive symptoms and diagnosis were influenced by genetic and nonshared environmental factors (h² = .30–.45). The genetic correlations between rumination and depression were moderate to large (rA = .40–.82), suggesting that a substantial proportion of the genetic influences on rumination overlap with those on depression. Results were similar when examining self-reported depressive symptoms and interview-based diagnosis of major depressive disorder. These results highlight the importance of rumination in the integration of cognitive and genetic models of depression risk.     

The Great Sustainability Challenge: How Visitor Studies Can Save Cultural Institutions in the 21st Century

ABSTRACT

Sustainability will be the great challenge for many cultural institutions in the first quarter of the 21st Century. Changing patterns of government, corporate, and individual support, new demographics, and new ways of creating, preserving, and sharing information are all challenging the sustainability of museums and other cultural institutions. In 2001 a meeting of science museum leaders in Bristol identified 3 distinct but interacting dimensions to sustainability: financial, intellectual, and social. Financial crises are the most obvious threats to the survival of institutions, but intellectual and social weaknesses can be equally dangerous and can make a temporary financial problem fatal. Visitor studies have the potential to provide crucial understandings that cultural institutions will need to build new, more sustainable models than the ones which served the previous century.     

The Opposites Task: Using General Rules to Test Cognitive Flexibility in Preschoolers

Executive functions play an important role in cognitive development, and during the preschool years especially, children's performance is limited in tasks that demand flexibility in their behavior. We asked whether preschoolers would exhibit limitations when they are required to apply a general rule in the context of novel stimuli on every trial (the “opposites” task). Two types of inhibitory processing were measured: response interference (resistance to interference from a competing response) and proactive interference (resistance to interference from a previously relevant rule). Group data show 3-year-olds have difficulty inhibiting prepotent tendencies under these conditions, whereas 5-year-olds’ accuracy is near ceiling in the task.     

Experimenter Behavior as an Unintended Determinant of Experimental Results

Sound motion pictures were made of 19 Es conducting a person perception experiment with 53 Ss. Ss' task was to rate the degree of success or failure of people pictured in photos. From some of the Ss, Es had been led to expect ratings of success and from some ratings of failure. Actually, Ss were assigned at random to the “success-perceiving” or “failure-perceiving” group, Es showed significant behavioral variation in the way in which they conducted the experiment, Es whose experimental behavior reflected greater interpersonal involvement or warmth obtained ratings of the photos as more successful, Es whose experimental behavior reflected a greater task orientation, greater competence, and a more professional manner obtained ratings significantly more in accordance with their expectancy, regardless of the particular nature of that expectancy.