The ontogeny of hemispheric specialization: some old hypotheses revisited

This paper re-examines two hypotheses on the ontogeny of hemispheric specialization that long ago fell into disfavor in neuropsychology. It is argued that these hypotheses, equipotentiality and progressive lateralization, may have suffered from misinterpretation that fostered premature acceptance of the developmental invariance view of hemispheric specialization. An alternative view is presented that incorporates both hypotheses within a neurodevelopmental context using anatomical (postmortem) and childhood aphasia data.     

Predicate-argument structure as a link between linguistic and nonlinguistic representations

We present a study wherein a severe Broca's aphasic patient was trained to learn symbols representing both pure transitive and dative predicates--predicates differing in argument structure--in a visually based artificial language (c-ViC). We found a decrease in performance when two symbols, rather than one, were used to depict these "verbs." However, this decrease in performance was more pronounced for symbols representing pure transitive verbs--those that allow only one argument structure--than for symbols representing dative verbs--those that allow two different argument structures. Also, dative "verbs" yielded better performance when they were inserted in more complex, three-argument "sentences" than when they were inserted in two-argument "sentences." The opposite pattern was found for pure transitives. These results are discussed in terms of our claim that argument structure serves as a point of connection between linguistic information and non-linguistic visual information and in terms of the possibility that argument structure entries are shaped by the form in which visual information is parsed.     

A kinematic analysis of anticipatory coarticulation in the speech of anterior aphasic subjects using electromagnetic articulography

An investigation was made into the extent and time course of anticipatory coarticulation in the speech of two normal and two anterior aphasic, German-speaking subjects. Both labial and velar coarticulation gestures were investigated. Subjects produced sentences containing target words contrasting in postconsonantal vowel rounding (e.g., [geli:ge]/[gely:gel]) and in nasality (e.g., [ti:de]/[ti:ne]). Speech kinematics were monitored by means of electromagnetic articulography. The data revealed that for correct productions, aphasic speakers' coarticulatory patterns were more highly variable than those of control subjects. These differences, however, were found chiefly for spatial displacement characteristics, while the temporal aspects of articulator movement necessary for anticipatory coarticulation appeared largely intact. Articulator mistiming did not appear to explain a small corpus of stop/nasal substitution errors produced by one of the aphasic speakers.     

Ethanol-mediated taste aversions and state-dependency in preweanling (16-day-old) rats

Requirements for conditioning of an ethanol-mediated taste aversion in 16-day-old rat pups were examined. Experiment 1 demonstrated that preweanling rats are capable of acquiring, in two trials, an aversion to a 15% sucrose solution when followed by intragastric intubation of a 1.2 g/kg dose of 17% v/v ethanol, but not when followed by a 0.4 g/kg dose. Comparison was with control animals given sucrose followed by an equivalent volume isocaloric Half and Half. When the 0.4 g/kg dose of ethanol preceded sucrose presentation by 30 min (Experiment 2), the aversion was learned, suggesting that the effective delay between the sucrose and the critical consequences of the ethanol had been too long with the former procedure. Expression of the sucrose aversion required, however, the reinstatement of the context of intoxication--state-dependent retention. Finally, the results of Experiment 3B indicated that, in addition to the association between the sucrose and the aversive consequences of alcohol intoxication, the orosensory cues resulting from alcohol's direct elimination, via such processes as respiration and salivation, became associated with the appetitive properties of the sucrose. This was evidenced by a conditioned increase in preference for ethanol odor. Possible age-related differences in the ability to associate stimuli with alcohol's unconditioned consequences, and in state dependency are discussed.     

Glucose and physostigmine effects on morphine- and amphetamine-induced increases in locomotor activity in mice

Recent findings indicate that glucose antagonizes several behavioral effects of cholinergic antagonists and augments those of cholinergic agonists. For example, scopolamine elicits increased locomotor activity, an action which is attenuated by glucose and by combined treatment with glucose and physostigmine at doses which are individually without effect. Opiate and catecholamine agonists, such as morphine and amphetamine, also elicit hyperactivity. The present study examined interactions of glucose and physostigmine with morphine- and amphetamine-induced hyperactivity. Mice received saline, morphine (10 mg/kg), or amphetamine (1 mg/kg) 50 min prior to testing, followed by saline, physostigmine (0.01, 0.05, 0.1, or 0.2 mg/kg), or glucose (10, 50, 100, or 500 mg/kg) administered 20 min prior to activity testing in an open field. Physostigmine significantly attenuated both morphine- and amphetamine-induced increases in activity, but higher doses were required to attenuate the effects of amphetamine. Like physostigmine, glucose significantly attenuated morphine-induced activity levels, but unlike physostigmine, glucose did not attenuate amphetamine-induced activity. Thus, the behavioral effects of morphine were more susceptible to modification by physostigmine and glucose than were the effects of amphetamine. The attenuation of morphine-induced hyperactivity demonstrates a similarity between glucose and cholinergic agonists, and also indicates that glucose may inhibit, directly or indirectly, opiate functions. More generally, these findings add to the evidence that circulating glucose levels selectively influence a growing list of behavioral and neurobiological functions.     

Values and Recovery From Alcoholism Through Alcoholics Anonymous

This report reviews the literature on the values of alcoholics and addicts in treatment and presents data that suggest a shift in values is involved in recovery from alcoholism through participation in Alcoholics Anonymous and that values clarification and value therapy may be useful in chemical dependency treatment.     

Women and AIDS

While the origin of the AIDS virus remains controversial, it is indisputable that AIDS is spreading worldwide. By June 1987, the World Health Organization estimated that 50 million Africans were infected with HIV and that the disease was epidemic in many parts of the continent. However, African governments chose to deny the threat of the disease. The AIDS crisis has diverted resources from other vital areas of disease prevention, health promotion, and research. Whereas AIDS is spread in developed nations by sexual promiscuity, by drug addicts sharing unclean hypodermic needles, and by homosexual behavior, in Africa cultural factors contribute to the transmission of AIDS. Female genital mutilation leads to extensive laceration of the female genitals upon initiation of sexual intercourse and/or to substitution of anal sex during the weeks and months before vaginal penetration can be achieved. In addition, the reuse of the same knives during the mutilation can spread HIV infection. Other factors that contribute to the spread of HIV in Africa include the patriarchal practice of polygamy, the subordinate position of women that makes them unable to insist on protection during intercourse, and a failure to screen blood used in transfusions. With all of these risk factors at play, women at the grassroots level must be equipped with the health education that is the only available tool to fight AIDS. Women's organizations can provide information and education to people at risk of acquiring HIV, counsel infected persons, ensure the safety of the blood supply, and work to overcome harmful traditional practices.     

Sources of difficulty in deductive reasoning: The THOG task

The THOG task presents four designs constructed from two shapes and two colours. Subjects are told that the experimenter has written down one of the shapes and one of the colours and are provided the rule that if, and only if, any design has either the shape or the colour, but not both, written down, then it is a THOG. Finally, they are given an exemplar and are asked to classify the remaining designs. Successful solution requires construction of hypotheses, reasoning under each hypothesis, and comparison of the results under each to reach a final conclusion. Few subjects are able to provide adequate responses on the standard version of the task. We present the results of four experiments, with 160 undergraduates each presented with one of eight versions of the task. Experiments 1 and 2 indicate that (1) some subjects think that the properties that are written down are identical to those of the exemplar, although these are not the same subjects who exhibit the modal error pattern, (2) many subjects correctly understand the disjunction of the rule but fail to consider the hypotheses, and (3) poor initial encoding of the problem is not easily corrected. Experiment 3 investigates the sufficiency of the claim of Griggs and Newstead (1982) that appropriate problem solution follows from explicit presentation of all problem information (including use of positive labels for properties that are not written down), and Experiment 4 investigates the necessity of the claim. The results of Experiments 3 and 4 show that presenting positive category labels does increase the frequency of correct solution; however, positive category labels are not necessary for such improvement. Separation of the labels of the THOG rule from those of the exemplar, or informing subjects that only one other design is a THOG, also increases the frequency of successful solution. The results suggest that many people have some fairly sophisticated reasoning skills. but application of these skills is easily discouraged when the features of the task lead to poor initial encoding.     

The lateralization of language comprehension using event-related potentials

Event-Related Potentials were recorded over occipital and parietal scalp from left- and right-handed adults presented with a language and a non-language visual stimulus using a divided field, "oddball" paradigm. The major finding of interest was that the P300 component was larger over the left than the right hemisphere of the right-handers when the language stimulus was presented to the left hemisphere; there were no hemispheric differences for the left-handers, regardless of field of presentation. These results are discussed in the context of developing noninvasive measures to lateralize language function.