Predictive genetic testing for conditions that present in childhood

There is a general consensus in the medical and medical ethics communities against predictive genetic testing of children for late onset conditions, but minimal consideration is given to predictive testing of asymptomatic children for disorders that present later in childhood when presymptomatic treatment cannot influence the course of the disease. In this paper, I examine the question of whether it is ethical to perform predictive testing and screening of newborns and young children for conditions that present later in childhood. I consider the risks and benefits of (1) predictive testing of children from high-risk families; (2) predictive population screening for conditions that are untreatable; and (3) predictive population screening for conditions in which the efficacy of presymptomatic treatment is equivocal. I conclude in favor of parental discretion for predictive genetic testing, but against state-sponsored predictive screening for conditions that do not fulfill public health screening criteria.     

Spatial location judgments: a cross-national comparison of estimation bias in subjective North American geography

We examined alternate explanations for distortions in the subjective representation of North American geography. One explanation, based on physical proximity, predicts that bias in location estimates should increase with the distance from a participant's home city or region. An alternative is that biases arise from combining accurate and inaccurate beliefs about the cities and the superordinate regions to which they belong, including beliefs that may have social or cultural origins. To distinguish these, Canadians from Alberta and Americans from Texas judged the latitudes of cities in Canada, the U.S., and Mexico. The Texans' estimates of Mexican locations were 16" (approximately 1,120 miles) more biased than their estimates of Canadian locations that were actually about 840 miles farther away. This finding eliminates proximity as a primary source of geographic biases and underscores the role of categorical beliefs as an important source of biased judgments.     

The impact of conflict of interest on trust in science

Conflicts of interest have an erosive effect on trust in science, damaging first the attitude of the public toward scientists and their research, but also weakening the trusting interdependence of scientists. Disclosure is recognized as the key tool for management of conflicts, but rules with sanctions must be improved, new techniques for avoidance of financial conflicts by alternative funding of evaluative research must be sought, and there must be new thinking about institutional conflicts of interest. Our profession is education, and both the public and research professionals of all ages would benefit from greater understanding of how science should and does work. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

Are The Very Happy Too Happy?

Although positive emotions undoubtedly confer benefits, one can have too much of it. There is probably a point beyond which enjoyment interferes with realism, yet it is unclear where that point is. The original States of Mind (SOM) model (Schwartz and Garamoni, 1986; 1989) proposed that a ratio of [positive] to [positive plus negative] affective/cognitive states [P/(P+N)] of about 0.62 is optimal, but previous research indicated that higher ratios may go with good mental health. The revised balanced states of mind (BSOM) model (Schwartz, 1997) suggests a higher cutoff, with ratios above 0.90 being dysfunctional. This paper reports a study of 72 very positive subjects (mean ratio = 0.85) and assessed possible dysfunction by means of questionnaires, role-plays, and physiological responses to induced stress. Signs of dysfunction were no more frequent among the most positive subjects (ratios of 0.90 and above) than among moderately positive subjects. This suggests that there is nothing wrong with the high levels of happiness in present day society. As yet, it is still not established how much more happiness will be too much. One possibility is that standard cognition/emotion measures need to be revised in order to detect truly excessive positivity in a sensitive manner.     

The Penn Psychoanalytic Treatment Collection: a set of complete and recorded psychoanalyses as a research resource

From a set of seventeen complete and tape-recorded psychoanalyses, a sample of findings is presented: (a) the level of agreement of two clinical judges on the psychological health of these patients is adequate for the late sessions, but not for the early sessions; (b) the amount of change during psychoanalysis appears to be similar to that in the Menninger Foundation Psychotherapy Research Project; (c) psychiatric severity measures from the early sessions can yield a significant level of prediction of the later benefits from psychoanalysis. Finally, further research uses of this collection of psychoanalyses are suggested.     

The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis

This individual differences study examined the separability of three often postulated executive functions-mental set shifting ("Shifting"), information updating and monitoring ("Updating"), and inhibition of prepotent responses ("Inhibition")-and their roles in complex "frontal lobe" or "executive" tasks. One hundred thirty-seven college students performed a set of relatively simple experimental tasks that are considered to predominantly tap each target executive function as well as a set of frequently used executive tasks: the Wisconsin Card Sorting Test (WCST), Tower of Hanoi (TOH), random number generation (RNG), operation span, and dual tasking. Confirmatory factor analysis indicated that the three target executive functions are moderately correlated with one another, but are clearly separable. Moreover, structural equation modeling suggested that the three functions contribute differentially to performance on complex executive tasks. Specifically, WCST performance was related most strongly to Shifting, TOH to Inhibition, RNG to Inhibition and Updating, and operation span to Updating. Dual task performance was not related to any of the three target functions. These results suggest that it is important to recognize both the unity and diversity of executive functions and that latent variable analysis is a useful approach to studying the organization and roles of executive functions.     

Modern hermeneutics and psychoanalysis

Contemporary hermeneutics tries to integrate our unique, local sense of things with overarching nature, often by celebrating the concrete phenomenology of the moment at the expense of scientific abstractions. But abstractions are unavoidable. Hermeneuticists point out that we are constantly making new abstractions. But the more optional and variable views, which we call subjective, depend on the old, reliable abstractions, such as time, space, substance, and causality, that constitute our fixed reality. Hermeneutics usefully challenges psychoanalysis to justify its way of slicing up the mind and treatment process.     

Rapid word identification in pure alexia is lexical but not semantic

Following the notion that patients with pure alexia have access to two distinct reading strategies-letter-by-letter reading and semantic reading-a training program was devised to facilitate reading via semantics in a patient with pure alexia. Training utilized brief stimulus presentations and required category judgments rather than explicit word identification. The training was successful for trained words, but generalized poorly to untrained words. Additional studies involving oral reading of nouns and of functors also resulted in improved reading of trained words. Pseudowords could not be trained to criterion. The results suggest that improved reading can be achieved in pure alexia by pairing rapidly presented words with feedback. Focusing on semantic processing is not essential to this process. It is proposed that the training strengthens connections between the output of visual processing and preexisting orthographic representations.     

Differential roles for visuospatial and verbal working memory in situation model construction

Two experiments investigated the processing of the spatial and causal dimensions of situation models. In Experiment 1, participants read texts varying in spatial and causal demands while responding to on-line spatial and causal probes. Experiment 2 used the same design, but used texts that more tightly integrated spatial and causal information. In both experiments, spatially oriented dependent measures were generally influenced by spatial, but not causal, demands, whereas causally oriented measures were influenced by causal, but not spatial, demands. In addition, spatially oriented dependent measures were generally correlated with a measure of spatial working memory capacity, whereas causally oriented measures were correlated with a measure of verbal working memory capacity. These results indicate that spatial and causal dimensions of situation models are maintained and elaborated independently in different working memory subsystems.