Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice

Although environmental enrichment improves spatial memory and alters synaptic plasticity in aged rodents, it is unclear whether all types of enrichment treatments yield similar benefits. The present study examined the effects in aged male mice of three types of enrichment on spatial memory in Morris water maze and radial arm maze tasks, and on levels of the presynaptic protein synaptophysin in several brain regions. Non-enriched young and aged males were compared with males exposed to one of the following treatments for 10 weeks: 5 min of daily handling, 3 h of daily basic enrichment, or 24 h of continuous complex enrichment. Young controls outperformed aged controls in both tasks. Neither daily handling nor daily enrichment affected spatial memory or synaptophysin levels. In contrast, continuous enrichment significantly reduced age-related spatial memory decline in both tasks, such that this group was statistically indistinguishable from young controls in most measures of performance. Continuously enriched mice were also significantly better than other aged mice in several spatial memory measures. Despite these improvements, synaptophysin levels in the continuous enrichment group were significantly lower than those of young and aged controls in the frontoparietal cortex, hippocampus, and striatum, suggesting a negative relationship between synaptophysin levels and spatial memory in aged males. These data demonstrate that different types of enrichment in aged male mice have disparate effects on spatial memory, and that the relationship between enrichment-induced changes in synaptophysin levels and spatial memory in aged males differs from that we have previously reported in aged female mice.     

Explanations of grouping in immediate ordered recall

This article is about grouping in immediate ordered recall. The following findings are reported: (1) grouping a presentation improves recall, even when steps are taken to prevent rehearsal; (2) grouping primarily improves recall of the items adjoining the grouping, creating primacy and recency within groups; and (3) this primacy and recency are found even when single, isolated errors in recall are considered. These results suggest that the effects of grouping cannot be fully explained by rehearsal, chunking, or the number of directions in which an item can be transposed. It is suggested instead that (1) the auditory short-term store contains an unparsed and uncategorized representation that must be parsed and categorized just prior to recall, in a process of recovery; (2) items adjoining the boundary of a presentation are more easily recovered; and (3) grouping creates a boundary within the presentation. To support this explanation, a final experiment demonstrates an interaction between type of stimuli and serial position, with grouping most improving recall of adjoining phonemes.     

Do Self-efficacy Expectation and Spirituality Provide a Buffer Against Stress-Associated Impairment of Health? A Comprehensive Analysis of the German Pastoral Ministry Study

We aimed to analyse stress perception, psychosomatic health and life satisfaction in pastoral professionals, paying particular attention to their individual and shared resources. Enrolling 8574 German pastoral professionals (48 % priests, 22 % parish expert workers, 18 % pastoral assistants, 12 % deacons), we found that pastoral professionals’ stress perception is associated with psychosomatic health impairment. General self-efficacy was a beneficial resource to protect against stress perceptions, while perception of the transcendent had a further yet weakly positive influence for stress-related impairment of health. External stressors (i.e. team size, duration of work per week and size of pastoral unit) were only of marginal independent relevance.     

The Potential Mediating Role of Parenting Practices in the Development of Conduct Problems in a Clinic-Referred Sample

Research has consistently found associations among parenting practices, socioeconomic disadvantage, ethnicity and conduct problems in children. We investigated whether parenting practices might mediate the relation between ethnicity and conduct problems and the relation between socioeconomic status (SES) and conduct problems. The subjects were 141 clinic-referred children between the ages of 6 and 17 and their primary custodial parents. Using multiple indicators for each construct, except ethnicity, the mediational role of parenting was tested using structural equation modeling. The results indicated that the effects of SES on conduct problems was largely mediated by the influence of ineffective parenting practices. In contrast, ethnicity was not associated with conduct problems in this clinic-referred sample, even prior to controlling for SES and parenting practices, suggesting that the link between minority status and conduct problems may be dependent on the demographic characteristics of the sample. Exploratory analyses also revealed that there were ethnic differences in the types of parenting practices that were most strongly associated with conduct problems.     

Developmental change in attention-deficit hyperactivity disorder in boys: A four-year longitudinal study

One hundred six clinic-referred boys meeting criteria for DSM-III-R attention-deficit hyperactivity disorder (ADHD) (mean age 9.4 years) were assessed annually for 4 years using structured interviews of multiple informants. Hyperactivity—impulsivity symptoms declined with increasing age, but inattention symptoms did not. Rather, inattention declined only from the first to the second assessment and remained stable thereafter in boys of all ages. The rate of decline in hyperactivity—impulsivity symptoms was independent of the amount and type of treatment received. Boys who still met criteria for ADHD in Years 3 and 4 were significantly younger, more hyperactive—impulsive, and more likely to exhibit conduct disorder in Year 1 than boys who no longer met criteria in Years 3 and 4.This study was supported by grant 1-R01-MH42529 from the National Insitute of Mental Health to Rolf Loeber and Benjamin B. Lahey.     

Effects of action on children’s and adults’ mental imagery

The aim of this study was to investigate whether and which aspects of a concurrent motor activity can facilitate children’s and adults’ performance in a dynamic imagery task. Children (5-, 7-, and 9-year-olds) and adults were asked to tilt empty glasses, filled with varied amounts of imaginary water, so that the imagined water would reach the rim. Results showed that in a manual tilting task where glasses could be tilted actively with visual feedback, even 5-year-olds performed well. However, in a blind tilting task and in a static judgment task, all age groups showed markedly lower performance. This implies that visual movement information facilitates imagery. In a task where the tilting movement was visible but regulated by means of an on-and-off remote control, a clear age trend was found, indicating that active motor control and motor feedback are particularly important in imagery performance of younger children.     

Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice

Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4(+)T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival. Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the therapeutic management of stress to improve the prognosis of cancer patients.     

Mothers,Fathers, and Parental Systems: A Conceptual Model of Parental Engagement in Programmes for Child Mental Health—Connect,Attend, Participate,Enact (CAPE)

Parenting programmes are one of the best researched and most effective interventions for reducing child mental health problems. The success of such programmes, however, is largely dependent on their reach and parental engagement. Rates of parental enrolment and attendance are highly variable, and in many cases very low; this is especially true of father involvement in parenting programmes. This paper proposes a conceptual model of parental engagement in parenting programmes—the CAPE model (Connect, Attend, Participate, Enact) that builds on recent models by elaborating on the interdependent stages of engagement, and its interparental or systemic context. That is, we argue that a comprehensive model of parental engagement will best entail a process from connection to enactment of learned strategies in the child’s environment, and involve consideration of individual parents (both mothers and fathers) as well as the dynamics of the parenting team. The model provides a framework for considering parent engagement as well as associated facilitators and mechanisms of parenting change such as parenting skills, self-efficacy, attributions, and the implementation context. Empirical investigation of the CAPE model could be used to further our understanding of parental engagement, its importance for programme outcomes, and mechanisms of change. This will guide future intervention refinement and developments as well as change in clinical practice.     

Self-Attributed Importance of Spiritual Practices in Catholic Pastoral Workers and their Association with Life Satisfaction

Although much is known about the frequency of the spiritual activities of pastoral workers, less is known related to how important specific spiritual and existential practices are to pastoral workers personally or existentially. This part of the German Pastoral Ministry Study analyzed (1) which forms of spiritual activities were regarded as important, (2) how the perceived importance of religious practices related to frequency of engagement in spiritual practices, and (3) how these practices contributed to the life satisfaction of ordained priests and of non-ordained pastoral workers. Participants included 1826 Catholic pastoral workers, composed of 65% priests and 35% (non-ordained) pastoral assistants and parish expert workers. Prosocial-Humanistic practices scored highest in importance, followed by Gratitude/Awe, Existentialistic practices, and Religious practices; specific forms of Spiritual Mind-Body practices were not relevant. Differences in the frequency and ascribed importance of spiritual practices between ordained and non-ordained pastoral workers were identified, as well as a surprising lack of connection between religious practices and their proclaimed importance, particularly of Prosocial-Humanistic and Gratitude/Awe practices. These findings may stimulate further research into the underlying causes of these differences between priests and other pastoral workers and between the frequency and importance of spiritual practices in all groups, which in the researchers’ opinion indicate challenging inconsistencies with regard to the ideals of religious vocations.