Spatial learning in the holeboard impairs an early phase of long-term potentiation in the rat hippocampal CA1-region

Long-term potentiation (LTP) and depression (LTD) are considered as cellular models for learning and memory. We studied the impact of holeboard training on LTP in the rat CA1 hippocampal region. In 7-week-old Wistar rats a recording electrode was chronically implanted into the hippocampal pyramidal cell layer of the CA1 of the right hemisphere and a stimulation electrode into the contralateral CA3 region.Two groups of animals received a spatial holeboard training of 10 or 15 trials over 2 days on a fixed pattern of baited holes. The last trial was performed 15 min after a primed burst stimulation of the contralateral CA3, which resulted in LTP in the ipsilateral CA1. A pseudo-trained group that received a 10 trial training with changing patterns of baited holes after each trial and a group that remained in the recording chambers during the experiments served as controls. Experimental rats significantly improved their spatial performance with increasing numbers of trials, indicated by decreasing times to pick up all food pellets and by decreasing numbers of reference memory errors. A learning-related impairment of CA1-LTP measured in both the population-spike amplitude as well as the fEPSP could be noted. These results show that specific (pattern-training), but not unspecific (pseudo-training) spatial information processing prior to electrical stimulation can severely affect LTP in hippocampal area CA1.     

CHRM3基因与孤独症谱系障碍

孤独症谱系障碍是一类具有遗传基础的儿童发展障碍疾病。近些年, 研究者们从分子病理学层面发现中枢胆碱能神经系统异常与孤独症患者认知和行为异常存在相关性。尸检研究、临床案例、动物模型研究均发现毒蕈碱型(M型)乙酰胆碱受体异常和孤独症的发生有着密切的关系。在以小鼠为模型的行为学研究中, 编码毒蕈碱型乙酰胆碱受体Ⅲ亚型的CHRM3基因突变会导致小鼠出现认知障碍、刻板行为等孤独症样表现。深入了解CHRM3基因的功能将能够帮助研究者进一步解释孤独症的相关行为特征, 为孤独症儿童教育方案的制定提供新的思路和方法。     

Biased assimilation: the role of source position

Biased assimilation is the tendency to evaluate belief‐consistent information more positively than belief‐inconsistent information. Previous research has demonstrated that biased assimilation is due to an inconsistency between an argument and the recipient's position toward this argument. The present research revealed that an inconsistency between a source's position (independently of the argument) and the recipient's position is also responsible for biased assimilation. In two studies, participants evaluated arguments stated by a politician. Party affiliation of the politician was correctly labeled, incorrectly labeled, or not labeled. The politicians' arguments were evaluated more favorably by their respective voters when party affiliation was correctly labeled. This biased evaluation diminished when party affiliation was not labeled and even slightly reversed when party affiliation was incorrectly labeled. Copyright © 2008 John Wiley & Sons, Ltd.     

Effectance and control as determinants of video game enjoyment.

This article explores video game enjoyment originated by games' key characteristic, interactivity. An online experiment (N=500) tested experiences of effectance (perceived influence on the game world) and of being in control as mechanisms that link interactivity to enjoyment. A video game was manipulated to either allow normal play, reduce perceived effectance, or reduce perceived control. Enjoyment ratings suggest that effectance is an important factor in video game enjoyment but that the relationship between control of the game situation and enjoyment is more complex.     

Improving health outcomes among youth with poorly controlled type I diabetes: the role of treatment fidelity in a randomized clinical trial of multisystemic therapy.

The purpose of the study was to assess whether therapist treatment fidelity was a predictor of treatment outcome in a randomized clinical trial of multisystemic therapy with 10- to 16-year-old youths with chronically poorly controlled Type I diabetes (N = 40). Treatment fidelity was assessed by objective ratings of therapy sessions and questionnaires completed by caregivers and by therapists. Relationships between fidelity measures were assessed. Structural equation modeling (SEM) was used to test whether high fidelity would lead to improved regimen adherence and to improved metabolic control outcomes via regimen adherence. Objective ratings of treatment fidelity were significantly related to therapist-reported but not to caregiver-reported treatment fidelity. SEM results supported a completely mediated pathway between treatment fidelity and metabolic control, with regimen adherence mediating the relationship. Results suggest that conducting complex behavioral interventions with a high degree of fidelity can improve treatment outcomes among youths with chronic illnesses.     

基于神经成像技术的青少年大脑发育研究

大脑成熟是一个动态过程, 高级神经活动的发育主要集中于个体发展的第二个10年：青少年时期。青少年时期是行为、认知和脑迅速发展的时期。青少年普遍表现出来的注意、冲动控制、计划、决策等认知能力的提高都是基于神经系统的成熟发展起来的。运用神经成像等技术的研究指出, 大脑在青少年时期的发展经历着突触精简以及髓鞘化的过程; 白质、灰质在青少年时期的成熟有不同的发展轨迹。青少年大脑皮层的成熟顺序与认知功能的发展相联系, 人脑的高级认知功能在青少年时期发展完成。在这一过程中, 脑的发展会受到情绪、环境以及经验等因素的影响。     

Ego depletion and positive illusions: does the construction of positivity require regulatory resources?

Individuals frequently exhibit positive illusions about their own abilities, their possibilities to control their environment, and future expectations. The authors propose that positive illusions require resources of self-control, which is considered to be a limited resource similar to energy or strength. Five studies revealed that people with depleted self-regulatory resources indeed exhibited a less-optimistic sense of their own abilities (Study 1), a lower sense of subjective control (Study 2), and less-optimistic expectations about their future (Study 3). Two further studies shed light on the underlying psychological process: Ego-depleted (compared to nondepleted) individuals generated/retrieved less positive self-relevant attributes (Studies 4 and 5) and reported a lower sense of general self-efficacy (Study 5), which both partially mediated the impact of ego depletion on positive self-views (Study 5).     

Terror salience and punishment: Does terror salience induce threat to social order?

In recent times, international terrorism has become one of the most serious concerns of the modern Western world. As a consequence, the risk and fear of terrorism is more salient in people’s minds (i.e. terror salience), which is supposed to affect behavioral responses in our society. The present research suggests that increased punishment of violations of criminal laws is one societal reaction to increased terror salience. It was consistently shown that increased terror salience, induced by either varying the temporal distance from the London terrorist attacks of July 7, 2005 (Study 1), by vignettes in the form of newspaper articles manipulating the expected terror risk (Study 2), or by pictures of recent terrorist attacks (Studies 3 and 4), significantly increased the punishment assigned to a violation of criminal laws that was completely unrelated to terror (i.e. car theft and rape). Finally, Study 4 revealed that (a) the effect of terror salience on punishment is indeed due to increased perception of threat to social order and (b) that this effect cannot be explained by the general negative nature of the stimulus material employed in this study.