Pilot programs in newborn screening

The term "pilot study" has been used over the years to describe the evaluation of the many elements involved in deciding whether a proposed condition should be added to a newborn screening (NBS) panel, and until recently, was unilaterally used to describe the evaluation of the assay to be used before the condition was officially adopted by a state for its newborn screening panel. Since Guthrie's introduction of screening for PKU, each time a new condition was added to the panel, the screening assay itself was validated through a population-based trial, in which the test was performed with de-identified samples to avoid association between the test result and the infant. This is considered by the laboratory as the "pilot phase" of adding a new condition. To advance the science of NBS, especially to accommodate new technologies that may provide new types of information (genetic versus physiological) for each new condition, pilot programs are essential. Involvement of the clinical community serves to improve these evaluations and provides the needed clinical validation of decisions made as a result of it. This paper describes the historical context of pilot programs in population-based NBS that utilize laboratory-based markers as indicators of concern; specifically, three applications that demonstrate different approaches to the use of pilots in adding conditions to a NBS panel are described.     

Hypertension reduction through forgiveness training

The objective of this study was to determine if patients with diagnosed stage-1 hypertension could benefit by a forgiveness training program to achieve measurable reductions in anger expression and blood pressure. Twenty-five participants were randomly divided into wait-listed control and intervention groups. The control group monitored blood pressure while the intervention group participated in an 8-week forgiveness training program. At the end of eight weeks, the wait listed group became an intervention group. Those who received forgiveness training achieved significant reductions in anger expression when compared to the control group. While reductions in blood pressure were not achieved by all the participants, those participants who entered the program with elevated anger expression scores did achieve significant reductions in blood pressure. It is suggested that forgiveness training may be an effective clinical intervention for some hypertensive patients with elevated levels of anger.     

Acceptance patterns of retaliatory aggression among adjudicated youth by sex and race

This study investigates sex and race differences in normative beliefs about the acceptability of aggression across dimensions of severity of provocation (weak versus strong) and sex of provoker (male versus female). Students in the sample of 311 included those required to attend three Department of Youth Services schools after placement by the juvenile court system from across the state of Alabama (N=392). Results show that males were significantly more likely than females to approve of retaliation to weak provocation and against females. There were no significant differences between males and females for retaliation with strong provocation and against males. Results also show the Black group was significantly more likely than the White group to approve of retaliation to weak provocation, strong provocation, and against females.     

The impact of financial and nonfinancial incentives on business-unit outcomes over time

Unlike previous behavior management research, this study used a quasi-experimental, control group design to examine the impact of financial and nonfinancial incentives on business-unit (21 stores in a fast-food franchise corporation) outcomes (profit, customer service, and employee turnover) over time. The results showed that both types of incentives had a significant impact on all measured outcomes. The financial incentive initially had a greater effect on all 3 outcomes, but over time, the financial and nonfinancial incentives had an equally significant impact except in terms of employee turnover.     

What is learned when concept learning fails?—A theory of restricted-domain relational learning

Two matching-to-sample (MTS) and four same/different (S/D) experiments employed tests to distinguish between item-specific learning and relational learning. One MTS experiment showed item-specific learning when concept learning failed (i.e., no novel-stimulus transfer). Another MTS experiment showed item-specific learning when pigeons’ novel-stimulus transfer decreased because they chose familiar training comparisons instead of matching novel comparisons. In 8-item and 3-item S/D tasks, pigeons and monkeys were accurate with unfamiliar training-stimulus pairings, stimulus inversions, and distorted stimuli, suggesting relational learning within a domain restricted to the training stimuli (i.e., no novel-stimulus transfer). In 32-item S/D tasks, pigeons with previous 8-item training showed less transfer than those without prior training, suggesting a carryover of restricted-domain relational learning. Pigeons shifted from 1024-item to 8-item S/D tasks showed reinstatement of restricted-domain relational learning. These findings are important in specifying which types of learning occur in these tasks, showing that subjects failing novel-stimulus transfer are not required to switch from item-specific to relational learning as a training set is expanded, and demonstrating that concept learning failure is not proof of item-specific learning.     

Depression and Social Anxiety in Children: Differential Links with Coping Strategies

Strategies that children use for coping with stressors are known to be related to emotional adjustment, but not enough is understood about specific links with social anxiety and depression. The present investigation tested differentiated associations of social anxiety and depression with specific types of coping strategies, and evaluated the direction of these associations over time. In Study 1, 404 children aged 8–13 years completed a coping scale modified from Kochendefer-Ladd and Skinner (Developmental Psychology 38:267-278, 2002) in order to evaluate factor structure and subscale internal consistency. In Study 2, 270 8–11-year-old children completed depression and social anxiety scales, a sociometric survey, and the coping scale from Study 1, with a follow-up timepoint 9 months later. In Study 1, factor analysis revealed six internally consistent coping subscales. In Study 2, social anxiety and depression were found to have distinctive longitudinal associations with subsequent coping strategies. Decreased problem-solving, social support-seeking, and distraction were uniquely predicted by depression but not by social anxiety. Internalising coping was a stronger outcome of social anxiety, and increased externalising was uniquely predicted by depression. There was also some evidence for a moderating role of peer relations. However, none of the coping strategies predicted changes in depression or social anxiety over the two timepoints. These results highlight the impact that emotional adjustment may have on children’s coping strategies, and clarify important distinctions between social anxiety and depression in relation to coping.     

Book reviews

John Christian Laursen (ed.). Religious Toleration: ‘The Variety of Rites’ from Cyrus to Defoe. New York, St Martin's Press, 1999. xx + 252 pp. $45.00. ISBN 0–312–22233–5.

Daniel Garber. Descartes Embodied: Reading Cartesian Philosophy through Cartesian Science Cambridge, Cambridge University Press, 2001, £40.00 hb; £14.95 pb. xii + 337 pp. ISBN 0–521–00337–7 pb. 0–521–80279–2 hb.

Olli Koistinen and John Biro (eds). Spinoza: Metaphysical Themes, Oxford, Oxford University Press, 2002. x + 255 pp. £40.00. ISBN 0–19–512815‐X.

Paul Abela. Kant's Empirical Realism. Oxford and New York, Clarendon Press, 2002. vii + 303 pp. £40.00. ISBN 0–19–924274–7.

Bruce L. Kinzer. England's Disgrace? J. S. Mill and the Irish Question. Toronto, Buffalo, and London, University of Toronto Press, 2001. 292 pp. $60. ISBN 0–8020–4862–5.

Maria Dimova‐Cookson. T. H. Green's Moral and Political Philosophy: A Phenomenological Perspective. Basingstoke, Palgrave, 2001. £40.00. xiii + 175 pp. ISBN 0–333–9144–7.

Stephen Mulhall. Inheritance &; Originality. Wittgenstein, Heidegger, Kierkegaard. Oxford, Clarendon Press, 2001. £40.00. xii + 448 pp. ISBN 0–19–924390–5.

Paul Gorner. Twentieth‐Century German Philosophy. Oxford, Oxford University Press, 2000. iii + 225 pp. £12.99. ISBN 0–19–289309–2.

Karen Green. Dummett: Philosophy of Language. Cambridge, Polity Press, 2001. xi + 236 pp. £55.00 (hb), £14.99 (pb). ISBN 0–7456–2294–1 (hb) 0–7456–2295‐X (pb).     

Peer influence on event reports among adolescents and young adults

When two or more people witness an event together, the event report from one person can influence others’ reports. In the current study we examined the role of age and motivational factors on peer influence regarding event reports in adolescents and young adults. Participants (N=249) watched a short video of a robbery then answered questions with no co-witness information or with information believed to be from a co-witness. Public and private response conditions were included to explore motivations for peer influence. Co-witness information influenced participants’ responses, although the effect was equally strong in the private and the public co-witness conditions. Peer influence on event reports was steady across a large age range (11- to 25-year-olds).