Predictive testing and oncogenes

Case vignette: sharing unanticipated genetic information. The Questor family has experienced an unusual number of malignancies in the past two generations and has been advised by an oncologist that the p53 oncogene known as Li-Fraumeni Syndrome may be present in the family genome. The option of predictive genetic testing has been raised and several branches of the family have chosen to undergo screening to determine whether they are at risk for cancer because of the gene. Roger and Liz Questor have arranged for screening of themselves and their three children, ages 12, 10, and 7. The couple has, by all appearances, been happily married for 14 years. None of the family members are found to carry the oncogene; however, the geneticist conducting the analyses has made an interesting incidental discovery. The 10-year-old child is not the biological progeny of Roger Questor. Although the 12- and 7-year-olds are clearly the biological children of the couple, it is evident that the 10-year-old born to Liz Questor was fathered by a person other than Roger. What are the ethical obligations of the geneticist with respect to any sharing or disclosure of the information that has been discovered incidentally? What course of action, if any, do you recommend?     

Attentional bias to threat: Roles of trait anxiety, stressful events, and awareness

Attentional biases for threat stimuli were assessed in high and low trait anxious subjects (n = 66) using a probe detection task. To examine the effects of trait anxiety and situational stressors, each subject was tested three times: Under no stress, laboratory-induced stress, and examination-induced stress. To evaluate the role of awareness, half the word stimuli were presented very briefly (14 msec) and masked, and the other half were presented for 500 msec without a mask. Results showed that high trait anxious subjects under exam stress showed an attentional bias towards unmasked threat stimuli compared with low trait subjects. This effect was not found under lab-induced stress, suggesting that the attentional bias for unmasked threat in high trait subjects may be a function of a prolonged stressor, rather than a transient increase in state anxiety. The results from the masked exposure condition were not predicted; high trait anxious subjects shifted attention towards the spatial location of threat words despite lack of awareness of their lexical content, but this bias was only apparent in the no-stress condition. The results are discussed in relation to recent cognitive theories of anxiety.     

Does stimulus correspondence account for the Simon effect? Comments on Hasbroucq and Guiard (1991)

Summary In a recent paper analysing the Simon effect, Hasbroucq and Guiard (1991) concluded that stimulus congruence, a correspondence relationship between stimulus components, accounts for the Simon effect and explains its reversal in the Hedge and Marsh experiment (1975). We contend that their definition of stimulus congruence is applied inconsistently, which invalidates their conclusion. It is argued here that the effect of display-control arrangement correspondence (Simon, Sly, & Vilapakkam, 1981) is an alternative account that fits the presented data better. In a second experiment, Hasbroucq and Guiard (1991) claimed to have invalidated the suggestion that display-control arrangement correspondence could be considered to be an alternative account of the findings in their Experiment 1. However, we assert that the type of display-control arrangement employed in their second experiment was so unpredictable that no effect of display-control arrangement correspondence could occur.     

Indirect modes of aggression among women of Buenos Aires,Argentina

This study utilizes the construct indirect aggression to investigate aggressive behavior among middle class Argentine women and men by administering an attitude and self-report survey to 95 inhabitants of Buenos Aires and by analyzing ethnographic interviews and observations conducted over a nine month period in 1992. An examination of sex roles in Argentina, including machismo and marianismo, provide a cultural context for interpreting aggression. Factor analyses revealed the presence of indirect aggression (e.g., social manipulation, gossip, exclusion) in addition to verbal and physical aggression. Survey and ethnographic findings converge in suggesting that women employ more indirect aggression than men, while men utilize more physical aggression. While competition and aggression are salient elements of social life for both sexes, women and men tend to favor different approaches. The findings are compared with the literature on female aggression from other cultural settings. We conclude that cultural and evolutionary perspectives elucidate aspects of female aggression.We would like to thank the Ford Foundation for providing the financial support to make this research possible. We would also like to thank Patricia de Gyldenfeldt and Debbie Bandura for their endless contributions with translations, ideas, and help in general. Finally, we would like to thank Eckerd College, la Universidad del Salvador, and Michael Hobson for their base of support, all those in Argentina, especially Agueda, Andrea, Carmen, Cecilia, Claudio, Daniela, Heidi, Ingrid, Javier, Julio, María, Mariela, Roberto, and Victor, who offered their enthusiastic assistance and ideas, and Victoria Burbank, Ayala Gabriel, and the anonymous reviewer for their helpful suggestions.     

Temporal discrimination learning of operant feeding in goldfish (Carassius auratus)

Operant temporal discrimination learning was investigated in goldfish. In the first experiment, there was a fixed daily change in illumination. Eight subjects were trained to operate a lever that reinforced each press with food. The period during which responses were reinforced was then progressively reduced until it was 1 hr in every 24. The final 1-hr feeding schedule was maintained over 4 weeks. The feeding period commenced at the same time each day throughout. The food dispensers were then made inactive, and a period of extinction ensued for 6 days. The pattern of responding suggested that the fish were able to exhibit temporal discrimination in anticipation of feeding time. This pattern of responding persisted for a limited number of days during the extinction procedure. The second experiment produced evidence that operant temporal discrimination could develop under continuous illumination.     

Exchange delays and impulsive choice in adult humans.

Choice responding by adult humans in a discrete-trial task was examined as a function of conditions that manipulated either the delay to point delivery or the delay between points and their exchange for money. In point-delay conditions, subjects chose between an "impulsive" alternative that provided a small amount of points immediately and a "self-control" alternative that provided a larger amount of points delayed by 15, 30, or 60 s. Points were exchanged for money immediately following the session. Subjects preferred the self-control alternative. In exchange-delay conditions, subjects chose between a small amount of points exchangeable for money immediately following the session and a larger amount of points exchangeable for money after 1 day, 3 weeks, or 6 weeks. A self-control preference observed for all subjects in the 1-day exchange-delay condition reversed to exclusive impulsive preference for 4 of the 6 subjects when choice conditions involved exchange delays of 3 or 6 weeks. These results show that human choice is sensitive to the manipulation of exchange delays and that impulsive preference can be obtained with exchange delays on the order of weeks.     

Functions of the environment in behavioral evolution

This paper explores some of the ways in which the environment functions with respect to behavior within an explanatory framework analogous to that of evolutionary biology. In both the behavioral and organic domains, the environment functions differently with respect to individual occurrences and evolutionary units. Within the behavioral domain, the problem of accounting for an occurrence of an operant instance differs from that of accounting for the existence of the operant unit of which the instance is a part. Maintaining these distinctions in levels of analysis within the behavioral domain, we focus first on operant units and operant instances as products of evolutionary processes occurring in the behavioral domain and second upon the causal role of the environment with respect to the existence of operant units and the occurrence of operant instances. The environment's function is selective with respect to origin, maintenance, suppression, and extinction of behavioral populations. At the level of operant instances, the environment has instantiating functions-evocative or alterative. Evocative functions are exemplified by discriminative relations, and alterative functions include both conditional and motivative relations. Implications are considered regarding extension of the analogy to more complex behavior-environment relations.     

U.S.- and Mexico-born Hispanic teen mothers: a descriptive study of factors that relate to postpartum compliance

Compliance with postpartum visits after teenage births in the US was examined among 289 Hispanic teenagers, of whom 127 were born in Mexico or border towns, who delivered at Harris County Hospital District and scheduled postpartum appointments at the Teen Health Clinic. The mean age was 17.31 years for mothers and 21.95 years for fathers. 56.7% (164) were married. 49.8% lived with husbands, 25.8% with parents, 22.3% with friends/relatives, and 2.1% alone. 74.7% stated that they had no social supports. 88.9% had a term delivery, 8.3% a preterm delivery, and 2.8% a fetal loss. 67.5% were first births, 5.5% had a previous abortion, and 3.1% had a previous miscarriage. 23.2% had a previous child, and 0.7% had a previous preterm delivery. Some form of prenatal care was received by 85.1%. 34.3% reported no further educational plans. 17.3% (50) returned for a scheduled postpartum visit. Mothers with a prior history of a premature birth or miscarriage were more likely to return postpartum compared to mothers with a first or prior birth. The differences are marginally significant. None of the mothers with a prior abortion returned. 34.9% of the returning teen mothers were more likely to have had prenatal care. Returning mothers also were a larger percentage of those with no future educational plans. 13.4% of returning mothers had an available social support system. Country of origin was not associated with support systems, prenatal care, return status, educational plans, pregnancy history, or current birth outcome. Out of the 50 returning, 20 were Mexican-born and married. Only Mexican marital status was found to be a significant variable explaining differences. Marital status had no effect on the 26 US native-born returnees. 92% of the Mexican-born teens were married and had a support system. The most dramatic feature of this study is the high level of noncompliance among both US-born and Mexican-born adolescents. There were few distinguishing features between these two groups. Return status was affected by very few features and was achieved by a very small percentage of the study population. The suggestion is made that poverty, a lack of health insurance, and poor knowledge of English, as representative of cultural dissimilarity, may be responsible for poor use of preventive care.     

Assessing Multicultural Counseling Competence: A Review of Instrumentation

The authors review four new instruments designed to assess multicultural counseling competence in trainees and practicing professionals. The Cross-Cultural Counseling Inventory—Revised (CCCI-R), the Multicultural Counseling Awareness Scale—Form B (MCAS:B), the Multicultural Counseling Inventory (MCI), and the Multicultural Awareness-Knowledge-and Skills Survey (MAKSS) were each critically reviewed in terms of item development, psychometric properties, and pragmatic utility. Specific research suggestions for continued empirical validation on the instruments are posited, and strong cautions regarding their current use in training are leveled.