Experiences of Women Who Have Had Carrier Testing for Duchenne Muscular Dystrophy and Becker Muscular Dystrophy During Adolescence

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive degenerative muscular conditions. Carrier testing is available to at-risk females. Though carrier testing is often offered to adolescent females, it raises ethical issues related to autonomy. This study aimed to address the impact of DMD/BMD carrier testing during adolescence, to elucidate what motivates adolescents to seek testing, and to assess the carrier testing experience. Retrospective semi-structured telephone interviews were conducted with 12 women out of 28 initially contacted. Data were coded using thematic analysis. For most (8/12) participants, discovering their carrier status during adolescence appeared to have helped alleviate uncertainty. The majority (9/12) of participants felt that they had made an autonomous decision and most (10/12) seemed to have adjusted well to their test result. Reproductive factors were framed as having been a key motivator prior to testing. However, following testing, participants’ views on prenatal diagnosis seemed more closely linked to their lived experience than to their test result. Just over half (7/12) the participants reported having not had the opportunity for genetic counseling prior to testing and after receiving their result, an issue that warrants further consideration.     

Generational Differences in Work-Related Attitudes: A Meta-analysis

Purpose

Differences among generations on a wide variety of outcomes are of increasing interest to organizations, practitioners, and researchers alike. The goal of this study was to quantitatively assess the research on generational differences in work-related attitudes and to provide guidance for future research and practice.

Design/Methodology/Approach

We conducted a meta-analysis of generational differences on three work-related criteria: job satisfaction, organizational commitment, and intent to turnover. Our review of published and unpublished research found 20 studies allowing for 18 generational pairwise comparisons across four generations (Traditionals, Baby Boomers, Generation Xers, and Millennials) on these outcomes using 19,961 total subjects.

Findings

Corrected mean differences for job satisfaction ranged from .02 to .25, for organizational commitment they ranged from ?.22 to .46, and for intent to turnover the range was ?.62 to .05. The pattern of results indicates that the relationships between generational membership and work-related outcomes are moderate to small, essentially zero in many cases.

Implications

The findings suggest that meaningful differences among generations probably do not exist on the work-related variables we examined and that the differences that appear to exist are likely attributable to factors other than generational membership. Given these results, targeted organizational interventions addressing generational differences may not be effective.

Originality/Value

This is the first known quantitative review of research on generational differences in the workplace.     

Recall bias for stimulus and response anxiety words in spider phobics

Abstract

Experiments on memory bias in patients with anxiety disorders have produced inconsistent results. It is suggested that results may depend on whether the words studied relate to anxiety-inducing stimulus features or to the anxiety response. It was predicted, following previous results, that phobic subjects would show diminished recall of stimulus words, but that recall of response words might be enhanced. In fact, for both stimulus and response words, phobics showed better recall of phobia-related words than of control words. The results are consistent with the hypothesis that phobic anxiety is associated with a bias towards recall of phobia-related words. However, it seems likely that phobic anxiety has several potentially conflicting effects on recall, and that this accounts for the inconsistent results in literature.     

Theology and Science

Abstract

The active engagement between science and religion is one of the preeminent ways in which we explore the sanctity of the world and the world reveals the sacred to us. Using Karl Rahner's concepts of transcendental/categorial causality and everyday mysticism, this paper enters into dialogue with the scientific insights of Stephen Hawking and Andrew Newberg, engaging the mystery of the cosmos and the mystery of the human person as an avenue to experiencing the mystery of God. In doing so, theology is challenged by scientific insight to a mysticism that engenders a less ontocentric and more humbly apophatic approach.     

Making your next move: Dorsolateral prefrontal cortex and planning a sequence of actions in freely moving monkeys

Prefrontal damage disrupts planning, as measured by disorders of the activities of daily living (Humphreys & Forde, 1998; Shallice & Burgess, 1991). In a monkey model of this form of planning, a variant of the delayed alternation task was performed by freely moving monkeys. In a 16 x 16-ft. testing room, four feeders were located in the middle of each wall. In the north task, monkeys alternated between feeders: west-north-east-north-west, and so forth. In the south task, the alternation sequence was east-south-west-south-east, and so forth. Neuronal activity was recorded during walking along the eight paths, constituting the north and south tasks. To succeed, monkeys had to memorize the alternation rule and monitor both their place in the sequence and the previously made spatially directed action before deciding to walk to a new location to the left or right of the current location. Responsive dorsolateral prefrontal neurons are strikingly selective. Sustained neuronal activity reflects the spatial direction of an ongoing or upcoming response. It is important that such selective responses occur in one but not both tasks, even though the movements are exactly the same in both tasks and at each location. We suggest that selective neuronal activity is tuned through learning and reflects the fundamental units of a planning mechanism: Individual neurons encode specific components of a sequence of behavioral actions and their temporal order. Populations of such neurons represent all the steps necessary to perform the north and south tasks. The sustained activity of these neurons suggests that planning and working memory mechanisms are integrated.     

Measurement of olfactory signal detectability using an air-dilution olfactometer

The Cheesman air dilution olfactometer, although designed for group threshold measurements, was modified to allow individual testing of subjects. However, adaptation effects of olfactory stimuli precluded use of interstimulus intervals of less than 30 sec. so that 3-hr. testing sessions were necessary to obtain a single measurement of sensitivity. Four subjects were tested intensively with isopropyl alcohol (CH3CH(OH)CH3) at concentration levels determined by previous group threshold studies. In the first condition, one concentration only was presented in testing sessions, while in the second condition, six concentrations were presented and the limits of concentrations adjusted to allow subthreshold presentations. Signal detectability indices (dc') were calculated more frequently and more reliably in the second condition than in the first.     

Questionnaire dimensions of spider phobia

The construction is described of a questionnaire designed to measure separate dimensions of cognitive-behavioural responsiveness to spiders in spider phobics. Dimensions of vigilance, preoccupation and coping-avoidance are established. Data are presented on differences between phobics and normals on the questionnaire, on correlations between the questionnaire measures and avoidance test measures, and on the effects of desensitization on the questionnaire measures.