Prior cocaine exposure disrupts extinction of fear conditioning

Psychostimulant exposure has been shown to cause molecular and cellular changes in prefrontal cortex. It has been hypothesized that these drug-induced changes might affect the operation of prefrontal-limbic circuits, disrupting their normal role in controlling behavior and thereby leading to compulsive drug-seeking. To test this hypothesis, we tested cocaine-treated rats in a fear conditioning, inflation, and extinction task, known to depend on medial prefrontal cortex and amygdala. Cocaine-treated rats conditioned and inflated similar to saline controls but displayed slower extinction learning. These results support the hypothesis that control processes in the medial prefrontal cortex are impaired by cocaine exposure.     

DISSOCIATION OF SPATIAL AND TEMPORAL COUPLING IN THE BIMANUAL MOVEMENTS OF CALLOSOTOMY PATIENTS

Abstract— The neural mechanisms of limb coordination were investigated by Jesting callosotomy patients and normal control subjects on bimanual movements. Normal subjects produced deviations in the trajectories when spatial demands for the two spatial deviations, although their hands moved with normal temporal synchrony. Normal subjects but not callosotomy patients exhibited large increases in planning and execution time for movements with different spatial demands for the two hands relative to movements with identical spatial demands for the two hands. This neural dissociation indicate that spatial interference in movements results from callosal connections whereas temporal synchrony in movement onset does not rely on the corpus callosum.     

Markers’ influence on the duration discrimination of intermodal intervals

The effects of sensory signal characteristics on the duration discrimination of intermodal intervals was investigated in three experiments. Temporal intervals were marked by either the successive presentation of a visual then auditory signal (VA), or by the successive presentation of an auditory then visual signal (AV). The results indicated that (1) VA intervals are generally easier to discriminate than are AV intervals, but this effect depends on the range of duration studied; (2) AV intervals are perceived as longer than VA intervals for durations ranging from 250 to 750 msec; (3) the intensity of the visual markers for both AV and VA intervals does not affect the discrimination; and (4) the perceived duration of an intermodal interval is influenced by the length of the first and second markers. The results are mainly interpreted in terms of (1) a sensory trace left by visual and auditory signals and (2) the detection of these signals.     

GPOWER: A general power analysis program

GPOWER is a completely interactive, menu-driven program for IBM-compatible and Apple Macintosh personal computers. It performs high-precision statistical power analyses for the most common statistical tests in behavioral research, that is,t tests,F tests, andχ ² tests. GPOWER computes (1) power values for given sample sizes, effect sizes andα levels (post hoc power analyses); (2) sample sizes for given effect sizes,α levels, and power values (a priori power analyses); and (3)α andβ values for given sample sizes, effect sizes, andβ/α ratios (compromise power analyses). The program may be used to display graphically the relation between any two of the relevant variables, and it offers the opportunity to compute the effect size measures from basic parameters defining the alternative hypothesis. This article delineates reasons for the development of GPOWER and describes the program’s capabilities and handling.     

A Quantitative Case Study of Longitudinal Changes in Identity, Intimacy, and Generativity

A quantitative case study of one woman's development was conducted in order to explore psychosocial change in early adulthood. A contentanalytic coding system for identity, intimacy, and generativity themes derived from E. H. Erikson's writing was applied to letters and diaries of the British writer Vera Brittain written when she was 20 to 21 and 30 to 31 years old. Over time, Brittain used more intimacy and generativity themes and fewer identity themes. Even though Brittain used fewer total identity themes in her writing in her early 30s, her use of one identity subcategory—occupational role—increased in frequency, and the way in which she expressed her identity concerns indicated greater certainty about her identity.     

Della sostanza

Inedito (Dal lascito, pp. 30604 – 30620) Con unaIntroduzione di Wilhelm BaumgartnerProbabilmente: Palermo, marzo 1900. Per la datazione, cf. la concordanza di contenuto con la lettera a A. Marty del 28 marzo 1900, in appendice.