Benjamin Franklin and shock-induced amnesia

Shock-induced amnesia received considerable attention after Cerletti popularized electroconvulsive shock therapy in the late 1930s. Yet, often overlooked is the fact that Benjamin Franklin recognized that passing electricity through the head could affect memory for the traumatic event. Franklin described his findings on himself and others in several letters from the mid-1700s, 2 of which were published in his lifetime. What he observed was confirmed in 1783 by physician Jan Ingenhousz, who was one of his correspondents. Although Ingenhousz had lost his memory for his electrical accident and was confused immediately afterward, he felt strangely elated and unusually sharp the next morning. Hence, he called for clinical trials with patients with melancholia who were not responding to more conventional therapies. After Franklin received Ingenhousz's letter, he also called for clinical trials. Neither man, however, tied the possible new cure for melancholia to the memory loss--nor did the operators that began to treat some patients with melancholia successfully with cranial shocks. Only much later would the amnesia be thought to be associated with the cure.     

Principles of early stopping of randomized trials for efficacy: a critique of equipoise and an alternative nonexploitation ethical framework

Recent controversial decisions to terminate several large clinical trials have called attention to the need for developing a sound ethical framework to determine when trials should be stopped in light of emerging efficacy data. Currently, the fundamental rationale for stopping trials early is based on the principle that equipoise has been disturbed. We present an analysis of the ethical and practical problems with the "equipoise disturbed" position and describe an alternative ethical framework based on the principle of nonexploitation. This framework acknowledges the need for balancing the dual ethical obligations of clinical research, the protection of human subjects and the generation of new medical knowledge. Based on this framework, we put forward a proposal to make early stopping guidelines more stringent under specified conditions. The temporary withholding of apparent benefits in certain circumstances is justified by achieving a fair contract with the research participants, one that protects them from undue harm and exploitation while reducing the many uncertainties surrounding new investigational treatments that arise when trials are stopped prematurely.     

Parsing surrounding space into regions

Surrounding space is not inherently organized, but we tend to treat it as though it consisted of regions (e.g., front, back, right, and left). The current studies show that these conceptual regions have characteristics that reflect our typical interactions with space. Three experiments examined the relative sizes and resolutions of front, back, left, and right around oneself. Front, argued to be the most important horizontal region, was found to be (a) largest, (b) recalled with the greatest precision, and (c) described with the greatest degree of detail. Our findings suggest that some of the characteristics of the category model proposed by Huttenlocher, Hedges, and Duncan (1991) regarding memory for pictured circular displays may be generalized to space around oneself. More broadly, our results support and extend thespatial framework analysis of representation of surrounding space (Franklin & Tversky, 1990).     

The Haskins Laboratories’ pulse code modulation (PCM) system

The pulse code modulation (PCM) method of digitizing analog signals has become a standard both in digital audio and in speech research, the focus of this paper. The solutions to some problems encountered in earlier systems at Haskins Laboratories are outlined, along with general properties of A/D conversion. Specialized features of the current Haskins Laboratories system, which has also been installed at more than a dozen other laboratories, are also detailed: the Nyquist filter response, the high-frequency preemphasis filter characteristics, the dynamic range, the timing resolution for single- and (synchronized) dual-channel signals, and the form of the digitized speech files (header information, data, and label structure). While the solutions adopted in this system are not intended to be considered a standard, the design principles involved are of interest to users and creators of other PCM systems.     

The black male urban barbershop as a sex-role socialization setting

Two hundred-eighty participants-as-observer hours and eight hours of informal interviewers with “informants” during a two-month period in summer 1983 were data sources in an analysis of a Black male urban barbershop in a midwestern city. The study focused on the barbershop as a sex-role socialization setting in which adult Black males actively negotiate masculinity while Black male youth passively negotiate masculinity and in all likelihood are socialized to become active negotiators. Content analyses of taped barbershop sessions and the researcher's written reports of the session revealed that the barbershop studied perpetuates sex-role stereotypes, encourages sexist attitudes toward women, and, in general, is a sex-role socialization setting that promotes sex-role inequality.     

A Qualitative Exploration of Sleep Habits and Intervention Needs Among Youth with Cystic Fibrosis

Evidence suggests that individuals with Cystic Fibrosis (CF) experience difficulties with sleep architecture and hygiene, although research is limited. There are currently no behavioral sleep interventions for youth with CF. The current study used qualitative methods to understand sleep needs and concerns among youth with CF, as well as to obtain feedback about potentially useful behavioral sleep intervention strategies. Semi-structured interviews were conducted with youth with CF between the ages of 11–17 and their parents. Themes were extracted from the data and will be used to inform the development of a brief behavioral sleep intervention for youth with CF. Youth and their parents described several CF-specific sleep concerns, often related to respiratory symptoms, and a number of strategies used to manage these concerns. They also described concerns that apply to the general population, including pervasive use of technology around bedtime. Many evidence-based behavioral sleep intervention strategies are acceptable to youth with CF, although modifications are appropriate to reduce time burden and address CF-specific needs. Youth with CF experience a number of disease-specific and more generalized sleep concerns which are likely amenable to behavioral intervention. Results from this study will be used to inform the development of a brief behavioral sleep intervention for youth with CF.