A neural model of normal and abnormal learning and memory consolidation: adaptively timed conditioning,hippocampus, amnesia,neurotrophins, and consciousness

How do the hippocampus and amygdala interact with thalamocortical systems to regulate cognitive and cognitive-emotional learning? Why do lesions of thalamus, amygdala, hippocampus, and cortex have differential effects depending on the phase of learning when they occur? In particular, why is the hippocampus typically needed for trace conditioning, but not delay conditioning, and what do the exceptions reveal? Why do amygdala lesions made before or immediately after training decelerate conditioning while those made later do not? Why do thalamic or sensory cortical lesions degrade trace conditioning more than delay conditioning? Why do hippocampal lesions during trace conditioning experiments degrade recent but not temporally remote learning? Why do orbitofrontal cortical lesions degrade temporally remote but not recent or post-lesion learning? How is temporally graded amnesia caused by ablation of prefrontal cortex after memory consolidation? How are attention and consciousness linked during conditioning? How do neurotrophins, notably brain-derived neurotrophic factor (BDNF), influence memory formation and consolidation? Is there a common output path for learned performance? A neural model proposes a unified answer to these questions that overcome problems of alternative memory models.     

Examining the Psychometric Properties of the Family Accommodation Scale-Parent-Report (FAS-PR)

Growing research has examined parental accommodation among the families of children with obsessive-compulsive disorder (OCD). However, these studies have utilized a parent-report (PR) version of a measure, the Family Accommodation Scale (FAS) that has never received proper psychometric validation. In turn, previously derived subscales have been developed via clinical rather than empirical evidence. This study aims to conduct a comprehensive psychometric analysis of the FAS-PR utilizing data collected from 96 youths with OCD. Exploratory factors analysis was conducted and revealed a 12-item scale yielding two separate, yet related subscales, Avoidance of Triggers (AT) and Involvement in Compulsions (IC). Subsequent analyses revealed good internal consistency and convergent and discriminant validity. These findings suggest that future research should seek to examine factors that may impact various facets to accommodation as well as the role these facets plays in predicting treatment outcome. Limitations are discussed.     

Relationships Among Religiousness,Spirituality, and Health for Individuals with Stroke

The current study evaluated the relationships among spiritual beliefs, religious practices, physical health, and mental health for individuals with stroke. A cross-sectional analysis of 63 individuals evaluated in outpatient settings, including 32 individuals with stroke and 31 healthy controls was conducted through administration of the Brief Multidimensional Measure of Religiousness/Spirituality (BMMRS) and the Medical Outcomes Scale-Short Form 36 (SF-36). For individuals with stroke, the SF-36 General Mental Health scale was significantly correlated with only the BMMRS Religious and Spiritual Coping scale (r = .43; p < .05). No other BMMRS factors were significantly correlated with SF-36 mental or physical health scales. Non-significant trends indicated spiritual factors were primarily related to mental versus physical health. This study suggests spiritual belief that a higher power will assist in coping with illness/disability is associated with better mental health following stroke, but neither religious nor spiritual factors are associated with physical health outcomes. The results are consistent with research that suggests that spiritual beliefs may protect individuals with stroke from experiencing emotional distress.     

Automatic evaluation of syntactic learners in typologically-different languages

Human syntax acquisition involves a system that can learn constraints on possible word sequences in typologically-different human languages. Evaluation of computational syntax acquisition systems typically involves theory-specific or language-specific assumptions that make it difficult to compare results in multiple languages. To address this problem, a bag-of-words incremental generation (BIG) task with an automatic sentence prediction accuracy (SPA) evaluation measure was developed. The BIG–SPA task was used to test several learners that incorporated n-gram statistics which are commonly found in statistical approaches to syntax acquisition. In addition, a novel Adjacency–Prominence learner, that was based on psycholinguistic work in sentence production and syntax acquisition, was also tested and it was found that this learner yielded the best results in this task on these languages. In general, the BIG–SPA task is argued to be a useful platform for comparing explicit theories of syntax acquisition in multiple languages.     

What is presentism?

Presentism has received much scrutiny of late, yet little has been said of its definition. Many assume that it means simply that all that exists, exists at present. However, this definition will not do. It is defective in a multiplicity of ways. I consider and reject each of a number of intuitive ways in which to amend it. Each carries us a bit closer to our goal, but not until the end do we reach a definition that is wholly satisfactory. The final definition has this remarkable feature: it has us posit abstracta of two kinds, namely, times and haecceities.     

Examining the Psychometric Properties of the Family Accommodation Scale-Parent-Report (FAS-PR)

Growing research has examined parental accommodation among the families of children with obsessive-compulsive disorder (OCD). However, these studies have utilized a parent-report (PR) version of a measure, the Family Accommodation Scale (FAS) that has never received proper psychometric validation. In turn, previously derived subscales have been developed via clinical rather than empirical evidence. This study aims to conduct a comprehensive psychometric analysis of the FAS-PR utilizing data collected from 96 youths with OCD. Exploratory factors analysis was conducted and revealed a 12-item scale yielding two separate, yet related subscales, Avoidance of Triggers (AT) and Involvement in Compulsions (IC). Subsequent analyses revealed good internal consistency and convergent and discriminant validity. These findings suggest that future research should seek to examine factors that may impact various facets to accommodation as well as the role these facets plays in predicting treatment outcome. Limitations are discussed.     

Processing of order information for numbers and months

Despite a great deal of research on the processing of numerical magnitude (e.g., the quantity denoted by the number 5), few studies have investigated how this magnitude information relates to the ordinal properties of numbers (e.g., the fact that 5 is the fifth integer). In the present study, we investigated order-related processing of numbers, as well as months of the year, with a novel ordering task to see whether the processing of order information differs from the processing of magnitude information. In Experiments 1 and 2, participants were shown three numbers (Experiment 1) or three months (Experiment 2) and were required to indicate whether the stimuli were in the correct order. In Experiment 3, participants were again shown three numbers; however, now they were instructed to indicate whether the three numbers were ordered in a forward, backward, or mixed direction. Whereas number comparison tasks typically reveal distance effects (comparisons become easier with increased distance between two numbers), these three experiments reveal a different pattern of results. There were reverse distance effects when the stimuli crossed a boundary (i.e., when numbers crossed a decade or months crossed the year boundary) and no effect of distance when the stimuli did not cross a boundary (i.e., when numbers were within a decade and months were within the January—December calendar year). These data suggest that additional mechanisms are involved in the processing of order information: a scanning mechanism and a long-term memory checking mechanism.     

Meno's Paradox,the Slave‐Boy Interrogation,and the Unity of Platonic Recollection

Plato invokes the Theory of Recollection to explain both ordinary and philosophical learning. In a new reading of Meno's Paradox and the Slave‐Boy Interrogation, I explain why these two levels are linked in a single theory of learning. Since, for Plato, philosophical inquiry starts in ordinary discourse, the possibility of success in inquiry is tied to the character of the ordinary comprehension we bring to it. Through the claim that all learning is recollection, Plato traces the knowledge achievable through inquiry back to our pretheoretical comprehension, showing not just that knowledge is in us, but that it is inchoate in the grasp of a property—akin to a concept—that enables us to speak and think about it ordinarily. Plato acknowledges in the Meno that a second step of argument, and a second application of Recollection, is needed to explain how knowledge comes to be inchoate in our ordinary grasp of a property. Though this second argument is provided most fully in the Phaedo, the evidence of the Meno is sufficient to outline Recollection as a two‐stage theory of learning, beginning in ordinary speech and thought and extending, through philosophical reflection, to knowledge.