Heart rate variability and drawing impairment in hypoxemic COPD

We studied 54 patients with hypoxemic chronic obstructive pulmonary disease (COPD). The Mini Mental State Examination and the Mental Deterioration Battery were used for neuropsychological assessment. Heart rate variability (HRV) was assessed based on 24-h Holter ECG recording. Mann–Whitney test was used to compare HRV parameters of patients performing normally or abnormally on individual neuropsychological tasks. Spearman’s rho was used to investigate the correlations between HRV parameters and neuropsychological scores, indexes of health status or COPD severity. Patients with defective performance at copying drawings with landmarks (CDL) test (N = 23) had lower very low frequency (VLF) power with respect to patients with normal performance (N = 31) (24 h: median 213; interquartile range 120–282 vs. 309; 188–431 ms², p = 0.043; daytime: 202; 111–292 vs. 342; 194–397 ms², p = 0.039). The CDL score correlated with the VLF power (24 h: ρ = 0.27, p = 0.049; daytime: ρ = 0.30, p = 0.028), and the normalized low frequency/high frequency (LF/HF) ratio (24 h: ρ = 0.27, p = 0.05; daytime: ρ = 0.33, p = 0.015). Sympathetic modulation decreased for increasing severity of COPD. In conclusion, drawing impairment correlates with depressed sympathetic modulation in patients with COPD, and both might be indexes of COPD severity.     

Event-related potentials to overlapping shapes: Effects of saliency and interference

Visual perception is often challenged by various difficulties that act concomitantly and whose respective impacts may therefore be hard to distinguish. We used event-related potentials to dissociate the impact of target saliency, generated by occlusion, from that of interference produced by incongruent nontargets. In one block, the target (a square) partially occluded another square tilted by 45°. This nontarget square interfered only to a small extent with target perception. In another block, the target was the occluded stimulus, and interference from the nontarget was substantial. Blocks including two kinds of overlapping shapes (a cross and a square) were added to control for the interference effect. Block comparisons revealed that occlusion modulated an occipital N250 and reaction times. In contrast, interference modulated a parietal N380 but not reaction times.     

Hallucinations in the psychotic state: Psychoanalysis and the neurosciences compared

In this contribution, which takes account of important findings in neuroscientific as well as psychoanalytic research, the authors explore the meaning of the deep‐going distortions of psychic functioning occurring in hallucinatory phenomena. Neuroscientific studies have established that hallucinations distort the sense of reality owing to a complex alteration in the balance between top‐down and bottom‐up brain circuits. The present authors postulate that hallucinatory phenomena represent the outcome of a psychotic's distorted use of the mind over an extended period of time. In the hallucinatory state the psychotic part of the personality uses the mind to generate auto‐induced sensations and to achieve a particular sort of regressive pleasure. In these cases, therefore, the mind is not used as an organ of knowledge or as an instrument for fostering relationships with others. The hallucinating psychotic decathects psychic (relational) reality and withdraws into a personal, bodily, and sensory space of his own. The opposing realities are not only external and internal but also psychic and sensory. Visual hallucinations could thus be said to originate from seeing with the ‘eyes’ of the mind, and auditory hallucinations from hearing with the mind's ‘ears’. In these conditions, mental functioning is restricted, cutting out the more mature functions, which are thus no longer able to assign real meaning to the surrounding world and to the subject's psychic experience. The findings of the neurosciences facilitate understanding of how, in the psychotic hallucinatory process, the mind can modify the working of a somatic organ such as the brain.     

Descartes’ Dog: a Clock with Passions?

Although much has been written on Descartes’ thought on animals, not so much has originated in, or has taken full account of, Descartes’ views on (human) emotions. I explore here the extent to which the latter can contribute to the debate on whether he embraced, and to which extent, the doctrine of the bête machine. I first try to show that Descartes’ views on emotions can help offer new support to the skeptical position without necessarily creating new tensions with other central aspects of his philosophy. And second, I sketch the type of theory of animal passions which Descartes could have accepted. The general conclusion I draw is not that Descartes did not hold the view of the bête machine but rather that we can find within his thought a solid stream of ideas, which became stronger towards the end of his life, that points in the opposite direction.     

Three Complexity Problems in Quantified Fuzzy Logic

We prove that the sets of standard tautologies of predicate Product Logic and of predicate Basic Logic, as well as the set of standard-satisfiable formulas of predicate Basic Logic are not arithmetical, thus finding a rather satisfactory solution to three problems proposed by Hájek in [H01].