Effects of (+) SKF 10,047, a sigma-1 receptor agonist, on anxiety,tested in two laboratory models in mice

Recently, sigma-1 receptor modulators have been considered drugs with an interesting therapeutic potential for the treatment of anxiety. However, there is no clear information in preclinical studies about the possible effects of sigma-1 ligands on anxiety in experimental animal models. Therefore, the present study examined the effects of (+)SKF 10,047 (2-8 mg/kg, ip), a sigma-1 agonist, on anxiety, tested in two classical laboratory models (social interaction test and elevated plus maze). (+)SKF 10,047 (8 mg/kg) produced a significant decrease of social investigation in the "social interaction test", whereas in the "elevated plus maze", the drug (4 and 8 mg/kg) provoked a significant reduction in the number of entries into open arms, as well as in the time spent in this area, as compared with the control group, without affecting motor activity. Overall, these findings indicate that (+)SKF 10,047 exhibits an anxiogenic-like profile in mice. It is suggested that anxiogenic effects of this sigma-1 ligand could be related to its potent ability to modulate diverse neurotransmitter systems involved in anxiety regulation.     

A latent variable approach to executive control in healthy ageing

It is a well-established finding that the central executive is fractionated in at least three separable component processes: Updating, Shifting, and Inhibition of information (Miyake et al., 2000). However, the fractionation of the central executive among the elderly has been less well explored, and Miyake's et al. latent structure has not yet been integrated with other models that propose additional components, such as access to long-term information. Here we administered a battery of classic and newer neuropsychological tests of executive functions to 122 healthy individuals aged between 48 and 91 years. The test scores were subjected to a latent variable analysis (LISREL), and yielded four factors. The factor structure obtained was broadly consistent with Miyake et al.'s three-factor model. However, an additional factor, which was labeled 'efficiency of access to long-term memory', and a mediator factor ('speed of processing') were apparent in our structural equation analysis. Furthermore, the best model that described executive functioning in our sample of healthy elderly adults included a two-factor solution, thus indicating a possible mechanism of dedifferentiation, which involves larger correlations and interdependence of latent variables as a consequence of cognitive ageing. These results are discussed in the light of current models of prefrontal cortex functioning.     

Predicting school achievement: The role of inductive reasoning,sleep length and morningness–eveningness

Adolescents move to evening orientation just when school schedule becomes earlier. Whereas school achievement has been associated to morningness orientation during morning school schedule, some studies have indicated that evening people are more intelligent. In this study the relative contribution of Morningness–Eveningness (M–E) in the prediction of school achievement, after controlling for age, sex/gender, inductive reasoning and sleep length was analyzed. Participants were 887 adolescents (aged 12–16). School achievement was evaluated using Grade Point Average (GPA), inductive reasoning was evaluated by reasoning subtest of Primary Mental Abilities (PMA-R), sleep length was calculated from rise time and bedtime questions, and M–E was evaluated by Morningness–Eveningness Scale for Children (MESC). Evening adolescents scored higher on PMA-R and obtained lower GPA. Inductive reasoning, age, sex/gender, sleep length and M–E accounted for 19% variance percentage on GPA. M–E was a significant predictor of school achievement even after controlling for traditional predictors, albeit slightly.     

My Group's Fate Is My Fate: Identity-Fused Americans and Spaniards Link Personal Life Quality to Outcome of 2008 Elections

People differ in their reactions to the outcomes of their group. Whereas some may revel in victory and mourn in defeat, others may internalize victory but distance themselves from defeat. Here, we sought to relate these divergent reactions to two forms of alignment with groups–identity fusion and group identification. Investigations of the 2008 elections in the United States and Spain revealed that people who were “fused” with their political party internalized both victory and defeat, but highly identified persons internalized only victory. We discuss how these findings bear on the conceptual distinctions between identity fusion and group identification.     

Parental Influences on Elite Aesthetic Athletes’ Body Image Dissatisfaction and Disordered Eating

Although different forms of parental influences on adolescents’ body image and eating disturbances have been studied, this relationship is nearly uninvestigated within the population of aesthetic athletes, a risk group for the development of eating disorders. The present study examined the role of specific family variables on the body image dissatisfaction (BID) and disordered eating (DE) of elite aesthetic athletes (n = 85) and controls (n = 142). Adolescents (M = 14.87 years, SD = 2.22) completed measures of direct influences (concern with thinness and weight teasing by parents), perceived quality of relationship with each parent and the overall family environment, BID and DE. Participants’ parents (223 mothers and 198 fathers) also completed measures of BID and DE. In general, parents of athletes do not present higher levels of BID or DE than do controls’ parents. Interesting differences were found between athletes’ and controls’ BID and DE predictors. Among athletes, direct parental influences are the only significant predictive family variable, which can reinforce the pressure to be thin found within elite-aesthetic contexts. The study’s findings highlight not only the importance of critical parental comments in athletes’ expression of BID and DE, but also of maternal modeling among adolescents in the general population. Such parental behavior may be an appropriate target in different prevention efforts.     

Mental models in propositional reasoning and working memory's central executive

We examine the role of working memory's central executive in the mental model explanation of propositional reasoning by using two working memory measures: the classical “reading span” test by Daneman and Carpenter (1980 Daneman, M. and Carpenter, P. A. 1980. Individual differences in working memory and reading. Journal of Verbal Learning and Verbal Behavior, 19: 450–466. [Crossref] , [Google Scholar]) and a new measure. This new “reasoning span” measure requires individuals to solve very simple anaphora problems, and store and remember the word solution in a growing series of inferential problems. We present one experiment in which we check the involvement of the central executive in conditional and disjunctive inference tasks and compare predictions of the new reasoning span test with those of the classical reading span test. The results of the experiment confirm that reasoning responses, which according to mental model theory require high cognitive work, are predicted by working memory measures. Results also show that some reasoning responses are probably obtained by means of superficial biases or strategies that do not load working memory. The reasoning span test, which involves the central executive to a greater degree, predicts reasoning performance better than the reading span test. The significance and possibilities of the new measure in studying reasoning are discussed.     

A set of high quality colour images with Spanish norms for seven relevant psycholinguistic variables: The Nombela naming test

ABSTRACT

This paper presents a new corpus of 140 high quality colour images belonging to 14 subcategories and covering a range of naming difficulty. One hundred and six Spanish speakers named the items and provided data for several psycholinguistic variables: age of acquisition, familiarity, manipulability, name agreement, typicality and visual complexity. Furthermore, we also present lexical frequency data derived internet search hits. Apart from the large number of variables evaluated, these stimuli present an important advantage with respect to other comparable image corpora in so far as naming performance in healthy individuals is less prone to ceiling effect problems. Reliability and validity indexes showed that our items display similar psycholinguistic characteristics to those of other corpora. In sum, this set of ecologically valid stimuli provides a useful tool for scientists engaged in cognitive and neuroscience-based research.     

Young Tennis Players’ Competitive Task Involvement and Performance: The Role of Goal Orientations,Contextual Motivational Climate,And Coach-Initiated Motivational Climate

The purpose of this study was to examine the role of situational and dispositional factors in contributing to competitive task involvement and performance in young tennis players. One hundred fifty-one adolescent tennis players and their coaches participated in the study. Participants responded to instruments measuring pre-game dispositional goal orientations and perceptions of the motivational climate and post-game task involvement in the competition by assessing concentration, loss of self-consciousness, and autotelic experience, perceptions of coach-initiated motivational climate in competition, and self-evaluation of game performance. In addition, coaches evaluated the players’ performance. Results showed that task involvement was predicted by players’ perceptions of a coach-initiated learning motivational climate in competition. Loss of self-consciousness was predicted by the players’ perceptions of a coach-initiated performance climate in competition. Finally, coaches’ and players’ assessment of performance were predicted by autotelic experience, concentration, and by perception of coach-initiated learning and performance orientation in competition.     

Performance of an Adapted Version of the Timed Up-and-Go Test in People with Cognitive Impairments

In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among groups. A cross-sectional study was conducted with 118 community-dwelling older adults divided in three groups: PC (n?=?40), MCI (n?=?40) and AD (n?=?38). The evaluation was composed by the adapted TUGT and cognitive assessment (Addenbrooke's Cognitive Examination and Frontal Assessment Battery). Only the cadence of TUGT presented significant difference between groups, specifically between AD versus MCI and PC groups. The main correlations were found between time of TUGT with fluency domain and global cognitive function, especially in the AD Group. The findings contribute to the understanding of how cognition interferes on functional mobility in older people with MCI and AD. The adapted TUGT is easy to perform in clinical practice and can be useful when assessing mobility in people with cognitive impairment.