Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning. During multitrial training in a shuttle box, the APV-injected rats were not different from the controls in sensitivity to shock or in acquisition of freezing to contextual cues. However, APV injection led to impaired retention of contextual fear when tested 48 h later, along with an attenuation of c-Fos expression in the amygdala. These results are consistent with the role of NMDA receptors of the BLA in long-term memory of fear, previously documented in Pavlovian conditioning paradigms. The APV-induced impairment in the active avoidance learning coincided with deficits in directionality of the escape reaction and in attention to conditioned stimuli. These data indicate that normal functioning of NMDA receptors in the basolateral amygdala is required during acquisition of adaptive instrumental responses in a shuttle box but is not necessary for acquisition of short-term contextual fear in this situation.     

Pavlov in Spain

Reflexology has been present throughout Spanish science since the last third of the nineteenth century and its importance can be seen in the works of authors such as Martín Salazar, Ramón y Cajal, Gómez Oca?a, Simarro and Turró. The most important research in Reflexology in Spain takes place a) at the Schools of Neurophysiology and Psychology in Barcelona and Madrid, b) with a group of authors specializing in pathological medicine and c) in the Military's Health Department, Pavlov's work was received in Spain with special interest. Fernández-Espa?a, who could be considered the "first Spanish Pavlovian," emphasized Pavlov's work in a series dedicated to the study of objective psychology which was published between 1914 and 1924. Planelles was the first investigator to develop a program in pavlovian experimentation, presenting his results in 1935. The Civil War (1936-1939) ended these and many other Spanish projects in psychology. After the war, interest in Reflexology and Pavlov's theories slowly rose again, first through psychosomatic medicine and then in the 60's because of the works of such authors as Monserrat-Esteve, Rof Carballo and Colodrón. The progressive inclusion of psychology in the Schools of Philosophy and Arts after 1968 marked the beginning of a new era.     

Stereotype development in Andalusian children

Social psychologists have shown a profound interest in intergroup relationships, but there are very few papers focusing on the developmental aspects that explain the psychological mechanisms involved in the construction of group and cultural identity. Our research aims to explore how the self-categorization of Andalusian children evolves. We tried to assess the degree to which they self-identify as Andalusian, Spanish, and European, and how this identification changes with age. We were also interested in the affective evaluation of different groups (French, Italian, English, German, Spanish, Catalonian, and Andalusian) made by Andalusian children. Furthermore, we analyzed the relationship between self-categorization and the evaluation of these groups. Results show that the development of national (autonomous community) identity in these children is influenced by their cognitive development, as well as by the relationships among the regional communities of Spain and the relationships between Spain and other countries. The peculiarity of Andalusians as a group is that they assume both identities: Spanish and Andalusian, from a very early age. In-group favoritism is an extended phenomenon at all ages, and Andalusian children have a negative stereotype of the other Spanish groups and other European communities.     

The effects of depression on the emotional responses of Spanish-speaking Latinas

Emotional responses (physiology, self-report, and facial expression) of 12 depressed and 10 nondepressed Spanish-speaking Latinas during sad and amusing film clips of human and animal content were compared. Depressed Latinas demonstrated less electrodermal reactivity across all the film clips and displayed fewer social smiles during the amusing-human film clip than nondepressed Latinas. No differences emerged for cardiovascular measures, reports of emotion, or facial expressions of happiness and negative emotion. Observed differences in electrodermal reactivity are similar to results from previous studies of Anglo Americans, suggesting that reduced electrodermal activity may be linked to depression across cultures. The findings also suggest that, for Latinas, depression may selectively alter expressions that serve interpersonal functions.     

The critical role of group studies in neuropsychology: comprehension regularities in Broca's aphasia

We reexamine the empirical record of the comprehension abilities of Broca's aphasic patients. We establish clear, commonly accepted, selection criteria and obtain a pool of results. We then subject these results to a detailed statistical analysis and show that these patients comprehend certain canonical sentences (actives, subject relatives, and clefts with agentive predicates) at above-chance levels, whereas comprehension of sentences that contain deviations from canonicity (passives, object-gap relatives, and clefts) is distinct and is at chance. That the latter is the case, and patients indeed guess at such structures, we show by comparing the distribution of individual results in passive comprehension to that of a model for such guessing-an analogous series of tosses of an unbiased coin. The two distributions are virtually identical. We conclude that the group's performance is stable, and well-delineated, despite intersubject variation whose source is now identified. This means that certain comprehension tests may not always be used for the diagnosis of individual patients, but they do characterize the group. It also means that group studies are not just a valid option in neuropsychology; they are a must, since demonstrations like ours indiciate very clearly that single-case studies may be misleading. As we show, the findings from any one patient, without the context of a group, may give a distorted picture of the pathological reality. Our conclusions thus promote studies of groups of brain-damaged patients as a central tool for the investigation of brain/behavior relations.     

Civic religion in England: Traditions and transformations

As the religious diversity of English towns and cities has grown over the past thirty years due to the establishment in some places of sizeable communities of Hindus, Muslims and Sikhs, as well as other faiths, there have been important changes to local public religion. Traditional civic ceremonies, such as Remembrance Sunday, as well as new forms of civic celebration and commemoration, are now increasingly taking account of the diversity of faiths represented in Britain. This paper examines the consequences of religious diversity for English civic religion by looking at some of the traditions of civic ceremonies in England and at the way in which they have been transformed by the changing religious landscape of towns and cities. The paper also explores some of the dilemmas and questions that have emerged both for the Church of England as well as for the other faith communities when it comes to the design and delivery of civic ceremonies.     

Einstein's theory of theories and types of theoretical explanation

In this paper I draw on Einstein's distinction between “principle” and “constructive” theories to isolate two levels of physical theory that can be found in both classical and (special) relativistic physics. I then argue that when we focus on theoretical explanations in physics, i.e. explanations of physical laws, the two leading views on explanation, Salmon's “bottom‐up” view and Kitcher's “top‐down” view, accurately describe theoretical explanations for a given level of theory. I arrive at this conclusion through an analysis of explanations of mass—energy equivalence in special relativity.