Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson’s disease

Despite the life-extending success of antiretroviral pharmacotherapy in HIV infection (HIV), the prevalence of mild cognitive impairment in HIV remains high. Near-normal life expectancy invokes an emerging role for age–infection interaction and a potential synergy between immunosenescence and HIV-related health factors, increasing risk of cognitive and motor impairment associated with degradation in corticostriatal circuits. These neural systems are also compromised in Parkinson’s disease (PD), which could help model the cognitive deficit pattern in HIV. This cross-sectional study examined three groups, age 45–79 years: 42 HIV, 41 PD, and 37 control (CTRL) participants, tested at Stanford University Medical School and SRI International. Neuropsychological tests assessed executive function (EF), information processing speed (IPS), episodic memory (MEM), visuospatial processing (VSP), and upper motor (MOT) speed and dexterity. The HIV and PD deficit profiles were similar for EF, MEM, and VSP. Although only the PD group was impaired on MOT compared with CTRL, MOT scores were related to cognitive scores in HIV but not PD. Performance was not related to depressive symptoms, socioeconomic status, or CD4⁺ T-cell counts. The overlap of HIV-PD cognitive deficits implicates frontostriatal disruption in both conditions. The motor-cognitive score relation in HIV provides further support for the hypothesis that these processes share similar underlying mechanisms in HIV infection possibly expressed with or exacerbated by ageing.     

The Essence of Cinema?

Philosophical Studies -     

Children’s prior experiences of their successes and failures modulate belief alignment

ABSTRACT

An ability to flexibly learn from others while at other times relying upon one’s own judgements is an important adaptive human capacity. The present research investigated how others’ epistemic states and prior experience of their own independent ability in a given task modulate young children’s selective learning. In particular, we asked whether 4-year-old children’s judgement concerning the location of a hidden object is modulated both by an informant’s knowledge states and by the absence/presence of a prior experience with a particular task. We found that the children were more likely to align their judgement according to the informant’s verbal report when the informant was knowledgeable than when she was ignorant – but only when they had explicitly experienced their own incapability to accurately guess an object’s location. The findings suggest that 4-year-old children are able to combine their own experience with others’ input to make their judgement.     

Don’t know,don’t care?

Philosophical Studies - My thesis is that moral ignorance does not imply a failure to care adequately about what is in fact morally significant. I offer three cases: one in which someone is...     

A Person-Centred Perspective on Social Support in the Workplace

This research seeks to identify employees’ profiles characterised by distinct perceptions of three sources of social support at work (i.e., organisation, supervisor, and colleagues), and the extent to which these profiles generalise across two samples of workers (N = 185 and 387). This research also investigates the associations between the profiles and a series of outcomes. Latent profile analysis revealed five identical profiles in both samples: (1) moderately supported; (2) isolated; (3) supervisor supported; (4) weakly supported; and (5) highly supported. The most desirable outcomes (job satisfaction, performance, and affective commitment) were associated with Profile 5 (highly supported), while the highest levels of emotional exhaustion were observed in Profile 2 (isolated).