An fMRI study on conceptual, grammatical, and morpho-phonological processing

The aim of the present study was to determine whether processing of syntactic word information (lemma) is subserved by the same neural substrate as processing of conceptual or word form information (lexeme). We measured BOLD responses in 14 native speakers of German in three different decision tasks, each focussing specifically on one level of lexical processing (conceptual, syntactic, and morpho-phonological). The test parameters were natural gender, grammatical gender, and word form derivation, respectively. Discrimination between words played backwards and complex sounds served as control task. Complex contrasts revealed a functional fractionation of the left inferior frontal gyrus for each level of lexical processing.     

Acquired ‘theory of mind'' impairments following stroke

The ability to attribute thoughts and feelings to self and others (‘theory of mind') has been hypothesised to have an innate neural basis and a dedicated cognitive mechanism. Evidence in favour of this proposal has come from autism; a brain-based developmental disorder which appears to be characterised by impaired theory of mind, despite sometimes good general reasoning skills/IQ. To date no case of specific acquired theory of mind impairment has been reported. The present study examined theory of mind in adults who had suffered right hemisphere stroke, a group known to show pragmatic and social difficulties. In one study using story materials and two using cartoons, patients' understanding of materials requiring attribution of mental states (e.g. ignorance, false belief) was significantly worse than their understanding of non-mental control materials. Data from healthy elderly subjects, and a small group of left hemisphere patients (who received the tasks in modified form), suggest that this impairment on mental state tasks is not a function of task difficulty. The findings support the notion of a dedicated cognitive system for theory of mind, and suggest a role for the healthy right hemisphere in the attribution of mental states.     

Effects of the Novel Acetylcholinesterase InhibitorN-Octyl-1,2,3,4-tetrahydro-9-aminoacridine on Locomotor Activity and Avoidance Learning in Mice

The acetylcholinesterase reversible inhibitorN-octyl-1,2,3,4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1–5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2–2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.     

The gap effect in newborns

In four experiments we investigated the gap effect in infants within the first 3 days of life. Reaction times (RTs) to make a saccade to a peripheral target were measured on gap trials, in which the central fixation stimulus went off 500 ms before target presentation, and on overlap trials, in which the central fixation stimulus remained on. In every experiment the fixation stimulus was a flashing light. The target stimulus was a schematic face in Experiment 1, a flashing light shown at 20° eccentricity in Experiment 2, a flashing light shown at 30° eccentricity in Experiment 3, and an upside-down schematic face in Experiment 4. In Experiments 1–3 a gap effect was found. That is, RT was faster on gap than on overlap trials. In contrast, the gap effect was absent in Experiment 4. These findings are consistent with the view that the superior colliculus plays a major role in producing the gap effect at birth.     

Rats build and update topological representations through exploration

Although rats are able to build complex spatial representations of their surroundings during exploration, the nature of the encoded information is still a matter for debate. In particular, it is not well established if rats can process the topological structure of the environment in such a way that they are aware of the connections existing between remote places. Here, rats were first exposed for four 5-min trials to a complex environment divided into several sectors that were separated by doors allowing either unrestricted or restricted access to other sectors. In the fifth test trial, we measured the behavior of the animals while they explored the same environment in which, however, they faced changes that either altered or did not alter the topological structure of the environment. In experiment 1, closing previously opened doors prevented the rat from having direct access between corresponding sectors. In experiment 2, opening previously closed doors allowed direct access between sectors that had not been directly accessible. In each experiment, control doors allowed us to discard the mere influence of door manipulation. We compared the rats’ exploratory behavior in response to door manipulations that either strongly altered or did not alter the ability to commute between sectors and found evidence that the animals displayed differential reactions to the two types of door manipulations. This implies that during exploration rats build a precise map of the connectivity of space that can be flexibly updated and used for efficient navigation.     

Sweeping dishonesty under the rug: how unethical actions lead to forgetting of moral rules

Dishonest behavior can have various psychological outcomes. We examine whether one consequence could be the forgetting of moral rules. In 4 experiments, participants were given the opportunity to behave dishonestly, and thus earn undeserved money, by over-reporting their performance on an ability-based task. Before the task, they were exposed to moral rules (i.e., an honor code). Those who cheated were more likely to forget the moral rules after behaving dishonestly, even though they were equally likely to remember morally irrelevant information (Experiment 1). Furthermore, people showed moral forgetting only after cheating could be enacted but not before cheating (Experiment 2), despite monetary incentives to recall the rules accurately (Experiment 3). Finally, moral forgetting appears to result from decreased access to moral rules after cheating (Experiment 4).     

Validation of an italian version of the oxford happiness inventory in adolescence

An Italian adaptation of the Oxford Happiness Inventory was administered to 782 adolescents. Exploratory structural equation modeling (ESEM) was used to examine the first- and second-order factorial structure of the scale and its invariance across gender; internal consistency and construct validity were also investigated. ESEM underlined a 5-factor structure (mastery and self-fulfillment, satisfaction with life, vigor, social interest, and social cheerfulness) that measures positive psychological functioning. These dimensions form a single latent construct of general psychological well-being. The scale showed adequate internal consistency values and strong measurement invariance across gender. Finally, regarding convergent validity, both total scale and subscales were positively correlated with extraversion and self-esteem, were negatively correlated with neuroticism, and displayed no correlation with psychoticism.     

Access to environmental stimulation via eyelid responses for persons with acquired brain injury and multiple disabilities: a new microswitch arrangement

This study assessed a new microswitch arrangement for eyelid responses using an optic sensor placed above the cheekbone and a small sticker on the person's eyelid. This new arrangement, which was designed to avoid interference of the microswitch with the person's visual functioning, was tested on three adults with acquired brain injury and multiple (consciousness, communication, and motor) disabilities. The study was carried out according to a non-concurrent multiple baseline design across participants. Data showed the new microswitch arrangement was suitable for all three participants, who increased their responding during the intervention phase of the study when their responses allowed them to access preferred stimulation. Practical implications of the findings are discussed.     

Reading aloud pseudohomophones in Italian: Always an advantage

In the present article, the lexical contribution to nonword reading was evaluated using Italian pseudohomophones that contained atypical letters or letter sequences. Pseudohomophones were read faster than orthographically matched nonwords in both mixed (Experiment 1) and pure (Experiment 2) lists; in addition, a base-word frequency effect was obtained in both conditions. The same pseudohomophone advantage was observed when nonwords without atypical letter sequences were mixed in the experimental list (Experiment 3 ), and it disappeared only in lexical decision, in which pseudohomophones were rejected as quickly as control nonwords. The pattern of results was explained by assuming that, due to their orthographic properties, the Italian pseudohomophones did not benefit from an orthographic lexical contribution and were mainly processed through the interaction system between the sublexical mechanisms and the phonological output lexicon.