Effects of the Novel Acetylcholinesterase InhibitorN-Octyl-1,2,3,4-tetrahydro-9-aminoacridine on Locomotor Activity and Avoidance Learning in Mice

The acetylcholinesterase reversible inhibitorN-octyl-1,2,3,4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1–5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2–2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.     

The gap effect in newborns

In four experiments we investigated the gap effect in infants within the first 3 days of life. Reaction times (RTs) to make a saccade to a peripheral target were measured on gap trials, in which the central fixation stimulus went off 500 ms before target presentation, and on overlap trials, in which the central fixation stimulus remained on. In every experiment the fixation stimulus was a flashing light. The target stimulus was a schematic face in Experiment 1, a flashing light shown at 20° eccentricity in Experiment 2, a flashing light shown at 30° eccentricity in Experiment 3, and an upside-down schematic face in Experiment 4. In Experiments 1–3 a gap effect was found. That is, RT was faster on gap than on overlap trials. In contrast, the gap effect was absent in Experiment 4. These findings are consistent with the view that the superior colliculus plays a major role in producing the gap effect at birth.     

Moral principles as moral dispositions

What are moral principles? In particular, what are moral principles of the sort that (if they exist) ground moral obligations or—at the very least—particular moral truths? I argue that we can fruitfully conceive of such principles as real, irreducibly dispositional properties of individual persons (agents and patients) that are responsible for and thereby explain the moral properties of (e.g.) agents and actions. Such moral dispositions (or moral powers) are apt to be the metaphysical grounds of moral obligations and of particular truths about what is morally permissible, impermissible, etc. Moreover, they can do other things that moral principles are supposed to do: explain the phenomena “falling within their scope,” support counterfactuals, and ground moral necessities, “necessary connections” between obligating reasons and obligations. And they are apt to be the truthmakers for moral laws, or “lawlike” moral generalizations.     

A cleansing fire: Moral outrage alleviates guilt and buffers threats to one’s moral identity

Why do people express moral outrage? While this sentiment often stems from a perceived violation of some moral principle, we test the counter-intuitive possibility that moral outrage at third-party transgressions is sometimes a means of reducing guilt over one’s own moral failings and restoring a moral identity. We tested this guilt-driven account of outrage in five studies examining outrage at corporate labor exploitation and environmental destruction. Study 1 showed that personal guilt uniquely predicted moral outrage at corporate harm-doing and support for retributive punishment. Ingroup (vs. outgroup) wrongdoing elicited outrage at corporations through increased guilt, while the opportunity to express outrage reduced guilt (Study 2) and restored perceived personal morality (Study 3). Study 4 tested whether effects were due merely to downward social comparison and Study 5 showed that guilt-driven outrage was attenuated by an affirmation of moral identity in an unrelated context.     

Parental Influence on Children with Attention-Deficit/Hyperactivity Disorder: I. Relationships Between Parent Behaviors and Child Peer Status

We examined associations between children’s peer relationships and (a) their parents’ social competence as well as (b) their parents’ behaviors during the children’s peer interactions. Participants were families of 124 children ages 6–10 (68% male), 62 with ADHD and 62 age- and sex-matched comparison youth. Children’s peer relationships were assessed via parent and teacher report, and sociometric nominations in a lab-based playgroup. Parental characteristics were assessed via parent self-report and observations of behavior during their child’s playgroup. After statistical control of relevant covariates, parents of children with ADHD reported poorer social skills of their own, arranged fewer playdates for their children, and displayed more criticism during their child’s peer interaction than did parents of comparison youth. Parents’ socialization with other parents and facilitation of the child’s peer interactions predicted their children having good peer relationships as reported by teachers and peers, whereas parental corrective feedback to the child and praise predicted poor peer relationships. Parents’ ratings of their child’s social skills were positively associated with ratings of their own social skills, but negatively associated with criticism and facilitation of the child’s peer interactions. Relationships between parental behaviors and peer relationships were stronger for youth with ADHD than for comparison youth. The relevance of findings to interventions is discussed.     

Potential Mediators in Parenting and Family Intervention: Quality of Mediation Analyses

Parenting and family interventions have repeatedly shown effectiveness in preventing and treating a range of youth outcomes. Accordingly, investigators in this area have conducted a number of studies using statistical mediation to examine some of the potential mechanisms of action by which these interventions work. This review examined from a methodological perspective in what ways and how well the family-based intervention studies tested statistical mediation. A systematic search identified 73 published outcome studies that tested mediation for family-based interventions across a wide range of child and adolescent outcomes (i.e., externalizing, internalizing, and substance-abuse problems; high-risk sexual activity; and academic achievement), for putative mediators pertaining to positive and negative parenting, family functioning, youth beliefs and coping skills, and peer relationships. Taken as a whole, the studies used designs that adequately addressed temporal precedence. The majority of studies used the product of coefficients approach to mediation, which is preferred, and less limiting than the causal steps approach. Statistical significance testing did not always make use of the most recently developed approaches, which would better accommodate small sample sizes and more complex functions. Specific recommendations are offered for future mediation studies in this area with respect to full longitudinal design, mediation approach, significance testing method, documentation and reporting of statistics, testing of multiple mediators, and control for Type I error.     

Analyzing Models of Career Decision Self-Efficacy: First-Order,Hierarchical, and Bifactor Models of the Career Decision Self-Efficacy Scale

The goal of the study was to examine the dimensionality of the Career Decision Self-Efficacy Scale Short Form (CDSES-SF, Betz et al. 1996). Integrating several previous findings from different cultures, we found that the bifactor structure of the CDSES-SF on a Hungarian sample of 649 respondents showed the best model fit. This structure includes a general CDSE factor covering 15 items and the original five specific factors (self-appraisal, occupational information, goal selection, planning, and problem solving) covering three items each. This short form of CDSES shows an acceptable model fit and appropriate reliability in terms of the Cronbach’s alpha and omega values. Regarding career decision self-efficacy, a large proportion of variance was explained by the general factor and to a smaller extent by the specific factors. These results can be considered as a first step in resolving the paradox of the dimensionality of CDSES-SF.     

Drug Use Among Immigrant and Non‐immigrant Adolescents: Immigrant Paradox,Family and Peer Influences

The present study compared immigrant and Italian native adolescents with regard to drug use. Additionally, we analysed the role of family and peer risk and protective factors for drug use. Participants included 2533 Italian native and immigrant adolescents (mean age = 17.19, SD = 1.6; 66.7% male). Results showed that immigrant adolescents reported lower levels of marijuana and pharmaceutical drug abuse than non‐immigrant adolescents. These results confirm the so‐called immigrant paradox phenomenon: the counterintuitive finding that although immigrants often live under challenging conditions and reported lower economic affluence compared with nationals, some health outcomes have not always corresponded to their relative disadvantage. Immigrant adolescents also reported higher level of parental control and lower levels of affiliation with deviant peers, but lower levels of child disclosure, parental solicitation and parental knowledge. Socio‐economic status and parental monitoring showed equivalent effects on drug use for immigrant and non‐immigrant adolescents. Results have implications for preventive interventions for immigrant adolescents and families, including the need to develop programmes that leverage the benefits of the immigrant paradox for immigrant communities. Future research should analyse the processes that lead to lower levels of drug use in immigrant adolescents and investigate the influence of friendship networks on immigrant adolescent drug use behaviour. Copyright © 2015 John Wiley & Sons, Ltd.     

A Population-Based Study of Children’s Well-Being and Health: The Relative Importance of Social Relationships,Health-Related Activities,and Income

This study investigated how various risk and protective factors interface with child health and well-being at the population level. Specifically, we examined the association of income, social-contextual variables, and indicators of health-related habits and activities to children’s life satisfaction and perceived overall health. Child data were collected via a self-report survey, the Middle Years Development Instrument, which was administered in three demographically diverse Canadian school districts to 5026 grade 4 students (83 % of the students had complete data and were included in the analyses). Multiple regression and mediation analyses were conducted to examine the joint associations of social relationships with adults and peers, nutrition and sleep habits, and after school sports activities with children’s satisfaction with life and perceived health. Results indicate that peer belonging and relationships with adults at home and school were the strongest predictors of life satisfaction. Furthermore, the (small) association between income and life satisfaction was mediated by social relationship variables. Child reports of perceived health were predicted by peer belonging, adult relationships (home, school, neighborhood), after-school team sports, and nutrition habits. The (small) association between income and health was mediated by social relationships and team sports participation. Findings are discussed in light of previous research on social determinants and socio-economic gradients of children’s health and life satisfaction.     

Temporal precedence of emotion over attention modulations in the lateral amygdala: Intracranial ERP evidence from a patient with temporal lobe epilepsy

Previous fMRI studies have reported mixed evidence for the influence of selective attention on amygdala responses to emotional stimuli, with some studies showing “automatic” emotional effects to threat-related stimuli without attention (or even without awareness), but other studies showing a gating of amygdala activity by selective attention with no response to unattended stimuli. We recorded intracranial local field potentials from the intact left lateral amygdala in a human patient prior to surgery for epilepsy and tested, with a millisecond time resolution, for neural responses to fearful faces appearing at either task-relevant or task-irrelevant locations. Our results revealed an early emotional effect in the amygdala arising prior to, and independently of, attentional modulation. However, at a later latency, we found a significant modulation of the differential emotional response when attention was directed toward or away from fearful faces. These results suggest separate influences of emotion and attention on amygdala activation and may help reconcile previous discrepancies concerning the relative responsiveness of the human amygdala to emotional and attentional factors.