代谢综合征的争议与共识

代谢综合征(metabolic syndrome,MS)的主要组分包括中心性肥胖、高血压、糖耐量异常、脂代谢紊乱,而胰岛素抵抗被认为是MS的病理生理学基础.目前,对MS的认识还存在诸多争议,主要包括MS的命名、病因机制和病理生理学基础、其各组分及其阈值的确定以及对心血管疾病的预测价值.尽管存在争议,MS概念的提出将有助于对高危人群的心脑血管疾病及糖尿病的防治.     

Coarse threat images reveal theta oscillations in the amygdala: A magnetoencephalography study

Neurocognitive models propose a specialized neural system for processing threat-related information, in which the amygdala plays a key role in the analysis of threat cues. fMRI research indicates that the amygdala is sensitive to coarse visual threat relevant information—for example, low spatial frequency (LSF) fearful faces. However, fMRI cannot determine the temporal or spectral characteristics of neural responses. Consequently, we used magnetoencephalography to explore spatiotemporal patterns of activity in the amygdala and cortical regions with blurry (LSF) and normal angry, fearful, and neutral faces. Results demonstrated differences in amygdala activity between LSF threat-related and LSF neutral faces (50–250 msec after face onset). These differences were evident in the theta range (4–8 Hz) and were accompanied by power changes within visual and frontal regions. Our results support the view that the amygdala is involved in the early processing of coarse threat related information and that theta is important in integrating activity within emotion-processing networks.     

A Comparison of Behavioral Parent Training Programs for Fathers of Children With Attention-Deficit/Hyperactivity Disorder

Few behavioral parent training (BPT) treatment studies for attention-deficit/hyperactivity disorder (ADHD) have included and measured outcomes with fathers. In this study, fathers were randomly assigned to attend a standard BPT program or the Coaching Our Acting-Out Children: Heightening Essential Skills (COACHES) program. The COACHES program included BPT plus sports skills training for the children and parent-child interactions in the context of a soccer game. Groups did not differ at baseline, and father ratings of treatment outcome indicated improvement at posttreatment for both groups on measures of child behavior. There was no significant difference between groups on ADHD-related measures of child outcome. However, at posttreatment, fathers who participated in the COACHES program rated children as more improved, and they were significantly more engaged in the treatment process (e.g., greater attendance and arrival on time at sessions, more homework completion, greater consumer satisfaction). The implications for these findings and father-related treatment efforts are discussed.     

The influence of chemical cues on the territorial prior residence effect in convict cichlids (cichlasoma nigrofasciatum Günther)

The importance of accumulated chemical cues on the occurrence of the territorial prior residence effect was investigated in two experiments using adult convict cichlids (Cichlasonul nigrofasciatum). In the first experiment, pairs of fish, matched on a number of criteria, were randomly assigned to three independent treatment conditions in which (1) the territorial marker (pot or clump of plants) was removed just prior to a direct encounter in the aquarium of the resident (pair member in whose aquarium the encounter took place) with accumulated chemical cues remaining intact; (2) the marker was removed, as well as the chemical cues; or (3) the marker was present, but the chemical cues were removed. Results showed that a significant prior residence effect occurred when the marker was present, but did not occur in either condition in which the marker was removed. A second experiment, in which the marker was removed and the gravel substrate altered, also did not reveal a signficant prior residence effect. Apparently, the territorial resident recognizes his territory by using certain visual cues, with accumulated chemical cues being neither necessary nor sufficient in this process.     

Within-session changes in operant responding when gerbils (Meriones unguiculatus) serve as subjects

Recent research has demonstrated that rate of responding frequently changes in a robust and systematic manner during experimental sessions in which organisms engage in operant responding. One potential cause for these changes in response rate is that levels of exploration change during experimental sessions and that high levels of exploration interfere with operant responding. Several studies have shown that gerbils (Meriones unguiculatus) explore at a constant rate during experimental sessions. The present study examined the response pattern produced by gerbils responding for food delivered by several simple schedules of reinforcement. Results indicated that robust changes (between 200 and 400%) in response rate occurred during the experimental sessions. These data argue against a role for exploration in the production of within-session changes in operant response rate.     

Within-session changes in operant responding when gerbils ( Meriones unguiculatus ) serve as subjects

Recent research has demonstrated that rate of responding frequently changes in a robust and systematic manner during experimental sessions in which organisms engage in operant responding. One potential cause for these changes in response rate is that levels of exploration change during experimental sessions and that high levels of exploration interfere with operant responding. Several studies have shown that gerbils (Meriones unguiculatus) explore at a constant rate during experimental sessions. The present study examined the response pattern produced by gerbils responding for food delivered by several simple schedules of reinforcement. Results indicated that robust changes (between 200 and 400%) in response rate occurred during the experimental sessions. These data argue against a role for exploration in the production of within-session changes in operant response rate. This material is based on work supported by the National Science Foundation under grant number IBN-9207346 awarded to FKM. The authors would like to thank Kelly S. Johnson, Samantha Swindell, and Dawn Miller for their help and useful suggestions concerning this project.     

Interruption of phonological coding in conduction aphasia

A case study of conduction aphasia, investigating single word repetition, phonological coding, and short-term memory, is reported. Evidence from intact adults suggests that repetition can occur through either a lexical route or a direct auditory-articulatory link. For this conduction aphasic, E.A., the direct link was impaired, although the lexical route could be used to produce accurate single word repetition. Several experiments demonstrated a significant impairment in the generation and maintenance of an abstract phonological code. The consequences of a disruption of phonological coding on speech perception and on verbal short-term memory are discussed.     

Single-word reading in college dyslexics

Recent studies of single-word processing in dyslexic populations have focused on the differential predictions made by ‘delay’ and ‘deviance’ models. Many experiments in this area have sought to determine whether the reading process in dyslexia is idiosyncratic or similar to processing in younger non-dyslexic readers. Most relevant research has, however, failed to take account of recent developments in theoretical models of reading. Furthermore, relatively little research has examined the reading behaviour of ‘highly compensated’ subjects, who achieve high-level academic qualifications despite their developmental dyslexia. The present paper examines such a population, and concludes that its single-word reading is governed by the same spelling-to-sound word characteristics as reading by other groups. The implications of the results for the deviance/delay hypothesis and for models of word naming are discussed.     

Social Density,Interpersonal Relationships,and Residential Crowding Stress1

Research has suggested that tripled rooms may be characterized by a coalition of two roommate(s) and a third, left-out rommate (i.e., the isolate) who is more vulnerable to crowding and control-related problems. The present study sought (1) to confirm the existence of two person coalitions in tripled rooms and (2) to further explore the mediating effects of interpersonal relationships on crowding stress and related problems. Thirty intact groups of roommates from doubled rooms (n= 60) and 39 intact groups of roommates from tripled rooms (n= 117) completed a set of surveys concerned with residential experiences. Results suggested that crowding stress previously associated with tripled residential settings may be mediated by interpersonal relationships; tripled residents who had negative interpersonal relationships with their roommates reported being more bothered by crowding, at both the beginning and end of the semester, than doubled residents who expressed negativity towards their roommate. Satisfaction with privacy was also influenced not only by the number of people with whom a resident shared a room, but also by the nature of the resident's interpersonal relationships with his/her roommate(s). Data also suggest that control-related problems may be a direct outcome of poor interpersonal relationships among inhabitants. Results also indicated that only a small percentage of tripled rooms were characterized by reciprocal, two person coalitions.