Metaplastic effect of apamin on LTP and paired-pulse facilitation

In area CA1 of hippocampal slices, a single 1-sec train of 100-Hz stimulation generally triggers a short-lasting long-term potentiation (S-LTP) of 1–2 h. Here, we found that when such a train was applied 45 min after application of the small conductance Ca²⁺-activated K⁺ (SK) channel blocker apamin, it induced a long-lasting LTP (L-LTP) of several hours, instead of an S-LTP. Apamin-induced SK channel blockage is known to resist washing. Nevertheless, the aforementioned effect is not a mere delayed effect; it is metaplastic. Indeed, when a single train was delivered to the Schaffer’s collaterals during apamin application, it induced an S-LTP, like in the control situation. At the moment of this LTP induction (15th min of apamin application), the SK channel blockage was nevertheless complete. Indeed, at that time, under the influence of apamin, the amplitude of the series of field excitatory postsynaptic potentials (fEPSPs) triggered by a stimulation train was increased. We found that the metaplastic effect of apamin on LTP was crucially dependent on the NO-synthase pathway, whereas the efficacy of the NMDA receptors was not modified at the time of its occurrence. We also found that apamin produced an increase in paired-pulse facilitation not during, but after, the application of the drug. Finally, we found that the induction of each of these two metaplastic phenomena was mediated by NMDA receptors. A speculative unitary hypothesis to explain these phenomena is proposed.     

Developmental changes in gender composition of friendship networks in adolescent girls and boys

This article describes both normative changes and individual differences in the gender composition of girls' and boys' friendship networks across adolescence and predicts variations in these changes. It also examines changes in the characteristics (context, age difference, closeness, and support) of same- and other-sex friendships in the network. Girls and boys (N=390) were interviewed annually from Grades 6 to 10 (76% retention). Growth in the proportion of other-sex friends was significantly more pronounced for girls and was related to different predictors for girls and boys. Moreover, over time, girls had other-sex friends that were increasingly older than themselves, and most of these friendships took place outside of the school, which was not the case for boys. Growth in the proportion of other-sex friends was more pronounced for secondary than for best friends. Finally, both girls and boys reported receiving higher levels of help from girls than from boys. These findings suggest that other-sex friendships might place some of the girls on a problematic developmental trajectory.     

An examination of the role of perceived support and employee commitment in employee-customer encounters

The authors examined the relationships between perceived organizational support, organizational commitment, commitment to customers, and service quality in a fast-food firm. The research design matched customer responses with individual employees' attitudes, making this study a true test of the service provider-customer encounter. On the basis of a sample of matched employee-customer data (N = 133), hierarchical linear modeling analyses revealed that perceived organizational support had both a unit-level and an employee-level effect on 1 dimension of service quality: helping behavior. Contrary to affective organizational commitment, affective commitment to customers enhanced service quality. The 2 sub-dimensions of continuance commitment to the organization--perceived high sacrifice and perceived lack of alternatives--exerted effects opposite in sign: The former fostered service quality, whereas the latter reduced it. The implications of these findings are discussed within the context of research on employee-customer encounters.     

Control-group study of an intervention training program for youth suicide prevention

Few studies have examined whether training can improve competency in intervening with suicidal youths. In this study we attempted to verify the effectiveness of such a training program on helper competency. Forty-three helpers who received the training were compared with 28 helpers who did not. Participants who received the training improved in knowledge, attitudes, and intervention skills following the training, compared with the control group across measures. Their gains were maintained at 6-month follow-up. In this sample, implementation of a one-time training program improved helpers' competencies in youth suicide intervention.     

Which Helper Behaviors and Intervention Styles are Related to Better Short‐Term Outcomes in Telephone Crisis Intervention? Results from a Silent Monitoring Study of Calls to the U.S. 1–800‐SUICIDE Network

A total of 2,611 calls to 14 helplines were monitored to observe helper behaviors and caller characteristics and changes during the calls. The relationship between intervention characteristics and call outcomes are reported for 1,431 crisis calls. Empathy and respect, as well as factor-analytically derived scales of supportive approach and good contact and collaborative problem solving were significantly related to positive outcomes, but not active listening. We recommend recruitment of helpers with these characteristics, development of standardized training in those methods that are empirically shown to be effective, and the need for research relating short-term outcomes to long-term effects.     

Immigrant children's peer acceptance and victimization in kindergarten: The role of local language competence

The study investigates peer acceptance and victimization of immigrant and Swiss children in kindergarten classes. Our first aim is to compare peer acceptance and victimization of Swiss and immigrant children. Secondly, we explore the role of their local language competences (LLCs). The sample was drawn from kindergartens in communities in the German‐speaking part of Switzerland. A representative sample of 568 boys and 522 girls (mean age 5.8 years) took part in the research. Teachers completed questionnaires on children's victimization, bullying, and LLC. The nationality background of parents was indicated by teachers and parents. To assess peer acceptance, a peer nomination method was used. Immigrant children showed less acceptance by peers and were more often victimized than their Swiss peers. There was a significant interaction effect for LLC and national background of mothers, showing that LLC was positively associated with peer acceptance for children of an immigrant background but not for Swiss children. Furthermore, peer acceptance mediated the effect of national background of mothers on victimization. Results are discussed in terms of the need to improve immigrant children's LLC.     

The personal myth: A re‐evaluation

This paper presents a re‐evaluation of Kris's personal myth. The notion has been used rather sparingly despite the Delphi Symposium in 1984 on the question of its clinical usefulness. After framing the notion of myth, some difficulties related to the question are identified. A clinical vignette exemplifies some of the ambiguities in its definition but stresses its clinical relevance. A discussion expands on these situations so as to propose three various aspects of personal myths to account for the two variants identified by Kris. The actualization of the underlying fantasy in the character organization is a third form and the technical aspect associated with it is reviewed from a new perspective. The family romance is revisited to reassess its role as the basis of the personal myth in the face of studies favouring an earlier development of the myth.     

Some Fundamentals of Integral Economics

There has been a growing interest in the integration of knowledge but few broad theoretical attempts in the field of economics. If integration is to be taken seriously, combining economic questions with the social and the natural sciences will not suffice. Psychology and the humanities will have to be incorporated, too. Inspired by the works of K. W. Kapp, C. G. Jung, and others, we develop a preliminary framework combining three key “integrative concepts”—(a) social metabolism, (b) the institutional structure, and (c) the inner world—within a perspective characterized by the interior/exterior distinction, evolution, openness, and the dialectics of potentials and actualizations. We argue that these three concepts help to integrate economics with the environment, the collective, and the self and spirituality. For each one of these integrated areas, we highlight some fundamental economic principles, namely (a) the implications of the differentiation of “natural resources,” (b) the signification of the distinction between property and possession, and (c) the need to take into account the unconscious and the individuation process in order to reach a realistic picture of the “economic actor” in search of existential fulfilment. Finally, we suggest sixteen economic propositions that could form a preliminary basis for an integral economics.     

French MEPs and religion: Europeanising ‘laïcité’?

What French members of the European Parliament (MEPs) believe and what they do as a result of these beliefs can be understood in comparison with what we know about MEPs from other member-states on the one hand, and about French national members of Parliament (MPs) and citizens on the other hand. French MEPs do not diverge much from MEPs of other nationalities in the way they deal with religion at the policy level. Significant French specificities remain regarding religion as a cultural and memory reference. The heritage of ‘laïcité’ leads to an emphasis on the separation between religion and politics and may be reactivated as a symbolic material to reassert French national identity in confrontation with other political traditions. Religious issues do not make for consensus and are still used as markers of ideological and party boundaries, between right and left and within each side, as they are a relatively costless resource to build a distinctive political profile. Beyond these distinctions, a ‘French way’ of handling religion is commonly acknowledged and ‘laïcité’ works as an encompassing and resilient framework. The European Parliament (EP) may offer a structure of opportunities and constraints to reformulate slightly the national narrative about religion, but it does not alter the beliefs and practices of French MEPs, who appear largely similar to French MPs and citizens to the extent that they are largely secularised and consider religion as a secondary purpose submitted to political rules and individual choice.