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231.
Reber SO Obermeier F Straub RH Veenema AH Neumann ID 《Stress (Amsterdam, Netherlands)》2008,11(3):225-234
Chronic subordinate colony housing (CSC) is a relevant chronic psycho-social stressor for male mice. Here, we investigated effects of CSC on the severity of dextran sulphate sodium (DSS)-induced colitis and the involvement of adrenal mechanisms. After 19 days of CSC, male C57BL/6 mice were treated with 1% DSS (8 days). After 8 days, inflammatory shortening of the colon and the histological inflammation score were increased in CSC mice. Additionally, the increased secretion of pro-inflammatory cytokines by mesenteric lymph node cells found on day 2 and 4 of DSS treatment was down-regulated in CSC mice on day 8 of DSS treatment, paralleled by an increase in plasma corticosterone. In contrast, in unstressed controls, elevation of cytokine secretion was delayed and only found on day 8 of DSS treatment, associated with a prompt rise in plasma corticosterone. To reveal adrenal mechanisms in CSC-induced effects on colitis, mice were adrenalectomized, exposed to CSC and treated with DSS (8 days). In adrenalectomized CSC mice, the severity of DSS-induced colitis was reduced, as body weight loss, shortening of colon, histological damage score, and cytokine secretion from mesenteric lymph node cells were diminished compared with sham-operated CSC mice. In conclusion, exposure to chronic psycho-social stress increases the severity of acute DSS colitis, an effect which is, at least partly, mediated by adrenal mechanisms. 相似文献
232.
233.
Previous research on advice taking has explained the failure to exploit collective wisdom in terms of the egocentric underweighting of advice provided by independent others. The present research is concerned with an opposite and more radical source of irrational advice taking, namely, the failure to critically assess the validity of advice due to metacognitive myopia. Participants could use the advice of one or two experts when estimating health risks. They read sketches of the study samples that experts had drawn to estimate conditional probabilities (e.g., of HIV‐given drug addiction). Whether samples were valid or seriously biased, subsequent judgments were strongly affected by any advice (Experiment 1). Uncritical reliance on any advice persisted when participants were sensitized to the contrast of valid and invalid advice in a repeated measures design (Experiment 2), when participants themselves believed advice not to be valid (Experiment 3), and even after full debriefing about invalid advice (Experiment 4). Lay advice exerted a similar influence as expert advice (Experiment 5). Although these provocative results are independent of numeracy and consensus (Experiment 6), they highlight the impact of metacognitive myopia as an impediment of social rationality. 相似文献
234.
Individual differences in components of reaction time distributions and their relations to working memory and intelligence 总被引:1,自引:0,他引:1
Schmiedek F Oberauer K Wilhelm O Süss HM Wittmann WW 《Journal of experimental psychology. General》2007,136(3):414-429
The authors bring together approaches from cognitive and individual differences psychology to model characteristics of reaction time distributions beyond measures of central tendency. Ex-Gaussian distributions and a diffusion model approach are used to describe individuals' reaction time data. The authors identified common latent factors for each of the 3 ex-Gaussian parameters and for 3 parameters central to the diffusion model using structural equation modeling for a battery of choice reaction tasks. These factors had differential relations to criterion constructs. Parameters reflecting the tail of the distribution (i.e., tau in the ex-Gaussian and drift rate in the diffusion model) were the strongest unique predictors of working memory, reasoning, and psychometric speed. Theories of controlled attention and binding are discussed as potential theoretical explanations. 相似文献
235.
The authors investigate different definitions of “psychic energy” and “libido” as well as their critique. With regard to “psychic energy” it is shown that the critique relates in particular to the perspective of Brenner and others and not to Freud's definition. They argue that Freud uses the term “psychic energy” as a synonym for “libido” and not “libido” as a synonym for “psychic energy”. It is assumed that until 1914, Freud related “libido” to manifestations of bodily sexual tensions and afterwards to manifestations of sexual energy in the psychic field. The authors reject this change for epistemological reasons as well as Freud's attempt to use dynamic, economic considerations as an explanatory device. Freud's energy concept is inconsistent with the definition of energy in natural sciences, and, whereas the meta-psychological topographical, dynamic and structural viewpoints have a solid foundation in the representational world to which the psychoanalytic process affords unique access, this is not true of the economic viewpoint. It is claimed that bodily tensions exist in the representational world only in the form of affects, so that the economic viewpoint should, in the authors' opinion, be abandoned in favour of an affective one. In the context of the endeavour to obtain pleasure and avoid unpleasure as adduced by Freud, this viewpoint concentrates on the relationships between affects and the different elements of the representational world, thereby serving as the topoi of meta-psychological investigation dimensions. 相似文献
236.
Hofer A Siedentopf CM Ischebeck A Rettenbacher MA Widschwendter CG Verius M Golaszewski SM Koppelstaetter F Felber S Wolfgang Fleischhacker W 《Brain and cognition》2007,63(2):159-166
In this functional MRI experiment, encoding of objects was associated with activation in left ventrolateral prefrontal/insular and right dorsolateral prefrontal and fusiform regions as well as in the left putamen. By contrast, correct recognition of previously learned objects (R judgments) produced activation in left superior frontal, bilateral inferior frontal, and right cerebellar regions, whereas correct rejection of distractor objects (N judgments) was associated with activation in bilateral prefrontal and anterior cingulate cortices, in right parietal and cerebellar regions, in the left putamen, and in the right caudate nucleus. The R minus N comparison showed activation in the left lateral prefrontal cortex and in bilateral cingulate cortices and precunei, while the N minus R comparison did not reveal any positive signal change. These results support the view that similar regions of the frontal lobe are involved in episodic encoding and retrieval processes, and that the successful episodic retrieval of newly learned objects is mainly based on a frontoparietal network. 相似文献
237.
Participants were German dyslexic readers (13-year-olds) who-compared to English dyslexic readers-suffer mainly from slow laborious reading and less from reading errors. The eye movements of eleven dyslexic boys and age-matched controls were recorded during reading of text passages and pseudoword lists. For both text and pseudoword reading, the dyslexic readers exhibited more and much longer fixations, but relatively few regressions. Increased length of words and pseudowords led to a greater increase in number of fixations for dyslexic than normal readers. Comparisons across studies suggest that the present German dyslexic eye movement findings differ from English-based findings by a lower frequency of regressions (presumably due to the higher regularity of German) and from Italian findings by longer fixation duration (presumably due to the greater syllabic complexity of German). 相似文献
238.
Tversky (1972) has proposed a family of models for paired-comparison data that generalize the Bradley—Terry—Luce (BTL) model
and can, therefore, apply to a diversity of situations in which the BTL model is doomed to fail. In this article, we present
a Matlab function that makes it easy to specify any of these general models (EBA, Pretree, or BTL) and to estimate their parameters.
The program eliminates the time-consuming task of constructing the likelihood function by hand for every single model. The
usage of the program is illustratedby several examples. Features of the algorithm are outlined. The purpose of this article
is to facilitate the use of probabilistic choice models in the analysis of data resulting from paired comparisons. 相似文献
239.
This article examines the relationship between interpersonal ego identity formation and congruence of self-attributed and implicit affiliation motives. A TAT-type picture-story test, the Personality Research Form, and the Extended Objective Measure of Ego Identity Status were administered to 177 participants to assess data on affiliation motivation and interpersonal identity formation. According to a scoring system developed by Winter, the picture stories were coded for need for Affiliation. Analyses revealed that motive congruence is significantly associated with participants' level of identity achievement and identity foreclosure in the interpersonal domain. Such a relationship could not be identified for identity diffusion and moratorium. 相似文献
240.
Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice 总被引:3,自引:0,他引:3
This study investigates the implication of the hippocampal CA3-region in the different phases of learning and memory in spatial and non-spatial tasks. For that purpose, we performed focal injections of diethyldithiocarbamate (DDC) into the CA3-region of the dorsal hippocampus. The DDC chelates most of the heavy metals in the brain which blocks selectively and reversibly the synapses containing heavy metals, i.e., the mossy fibres synaptic buttons and synapses of the dendrites of pyramidal cells. The effects of temporal inactivation of the CA3-region was examined in a non-associative task, the spatial open-field, designed to estimate the ability of mice to react to spatial changes, and in the object recognition task, designed to estimate the ability of mice to identify a familiar object. The results show that DDC induced a specific impairment on learning and memory consolidation in the spatial open-field but had no effect on recall in this task. In the object recognition task, DDC did not induce any impairment in the different phases of learning and memory. These data demonstrate that the hippocampal CA3-region is specifically implicated in spatial information processing and seems to be involved not only in acquisition but also in consolidation of spatial information. 相似文献