Is There a Moral Obligation to Develop Brain Implants Involving NanoBionic Technologies? Ethical Issues for Clinical Trials

In their article published in Nanoethics, “Ethical, Legal and Social Aspects of Brain-Implants Using Nano-Scale Materials and Techniques”, Berger et al. suggest that there may be a prima facie moral obligation to improve neuro implants with nanotechnology given their possible therapeutic advantages for patients [Nanoethics, 2:241–249]. Although we agree with Berger et al. that developments in nanomedicine hold the potential to render brain implant technologies less invasive and to better target neural stimulation to respond to brain impairments in the near future, we argue against presenting the development of nanobionic clinical devices in terms of a moral obligation to conduct this research. In the first part of the paper, we consider what a duty to pursue new technologies might mean, and in the second we explore some of the negative consequences of defending such development as a moral obligation based on potential benefit. We argue that promoting the advances available to brain implants through developments in nanotechnology and bionics could contribute to medical rhetoric that indirectly increases the risk of exposing patients to harm when participating in clinical trials. We argue that rather than there being a moral obligation to improve nanobionics implants because of their potential benefit, the pursuit of improved neuro implants must be balanced against the prima facie obligations to protect patients against harm and to promote and protect patient autonomy.     

Innovative Assessment of Childhood Trauma and Its Link to HIV and Substance Abuse in Post-Incarcerated Women

Women who are incarcerated often report unresolved early life traumas, which research has linked to subsequent HIV and substance abuse risks. This article presents an arts-based counseling technique used with women re-entering society after incarceration. Women were assessed for childhood trauma (i.e. sexual, emotional, and/or physical abuse) in relation to age of onset and frequency of events using an interactive pictorial assessment technique, Healing Me Timeline activity. The technique allowed women to use color-coded graphs in identifying points along a timeline during which traumatic events occurred and to process insights to foster healthy coping strategies. The timeline activity was an innovative and gender-appropriate method for uncovering the nature and extent of women’s trauma and counseling needs. Facilitators used the counseling tool to assist women in processing personal insights and to make referrals to mental health counseling, medical services, and substance use programs.     

Can self-affirmation exacerbate adverse reactions to stress under certain conditions?

Objective: Self-affirmation has repeatedly been shown to reduce adverse psychological and physiological responses to stress. However, it is plausible that self-affirmation could exacerbate negative reactions to stress under certain conditions. The current research explored whether self-affirmation would increase negative psychological responses to a stressor occurring in a central life domain characterised by low levels of control.

Design: Female participants (Study 1 N = 132; Study 2 N = 141) completed baseline measures of anxiety and mood. They were then randomly allocated to complete a self-affirmation or control task, before reading a narrative documenting a stressful birth and imagining themselves in the place of the woman giving birth. After completing this task, participants again reported their levels of anxiety and positive mood.

Main outcome measures: Anxiety and positive mood assessed at follow-up.

Results: Study 1 demonstrated that self-affirmed women experienced increased anxiety and less positive mood at follow-up, compared both to baseline and to women in the control condition. Study 2 revealed that the effect of self-affirmation on outcomes was moderated by fear of childbirth.

Conclusion: These results provide preliminary evidence that self-affirmation may worsen negative responses to stressors under certain conditions and for certain individuals.     

A meta‐analysis of the effects of speakers' accents on interpersonal evaluations

This paper reports a meta‐analysis of the empirical literature on the effects of speakers' accents on interpersonal evaluations. Our review of the published literature uncovered 20 studies that have compared the effects of standard accents (i.e., the accepted accent of the majority population) versus non‐standard accents (i.e., accents that are considered foreign or spoken by minorities) on evaluations about the speakers. These 20 studies yielded 116 independent effect sizes on an array of characteristics that were selected by the original researchers. We classified each of the characteristics as belonging to one of three domains that have been traditionally discussed in this area, namely status (e.g., intelligence, social class), solidarity (trustworthiness, in‐group–out‐group member), and dynamism (level of activity and liveliness). The effect was particularly strong when American Network accented speakers were compared with non–standard‐accented speakers. These results underscore prior research showing that speakers' accents have powerful effects on how others perceive them. These and other results are discussed in the context of the literature along with implications for future research in this area. Copyright © 2011 John Wiley & Sons, Ltd.     

Thematic moment analysis: A didactic application of a procedure for phenomenological analysis of narrative data

Abstract

Following in the theoretical and methodological roots of the ‘Duquesne school,’ this work presents a procedure for the phenomenological analysis of narrative data. After describing its ‘approach,’ this work lays out the procedure for ‘thematic moment analysis’ using the work of Giorgi as a point of reference. Idiographic results of single datum of being afraid are presented along with the steps through which this ‘idiographic thematic narrative’ was developed. Procedures for arriving at ‘comparative analysis’ of more than one piece of data are presented and distinguished from claims of generality sought by works drawing on larger data pools. Finally, this work discusses issues of internal and external validity both specifically in regards to the ‘thematic moments’ procedure and in terms of phenomenological research in general.     

Unwed Teenage Mothers: An Ounce of Prevention Is Worth a Ton of Cure

A problem that impacts many segments of our society today can be directly traced to unwed adolescent girls giving birth. This article details the consequences and impact such births have on our nation as a whole, and explores ways to prevent the pregnancies rather than merely offering up more coping solutions once such teenage girls become pregnant.     

Knowledge and the Prediction of Behavior: The Role of Information Accuracy in the Theory of Planned Behavior

The usefulness of a combined protection motivation and self-efficacy theory as a model of health enhancement was investigated via a persuasive communications paradigm. Self-efficacy expectancy, outcome expectancy (i.e., perceived response efficacy) and outcome value (i.e., perceived social value) of a health-enhancing behavior were manipulated. As predicted, both self-efficacy expectancy and response efficacy had significant main effects on subjects' intentions to perform the health-enhancing behavior. Outcome value had no significant effect on behavioral intentions. Correlational data indicated that response efficacy was the best single predictor of intentions and that self-efficacy expectancy was also a significant predictor of intentions. Outcome value added no predictability. These results support the utility of the combined protection motivation and self-efficacy theory as a model of health enhancement.     

White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis

Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20–25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure–function relationships in human language system.