Opioid mechanisms are involved in the disruption of arcaine-induced amnesia by context pre-exposure

Previous exposure to the training context disrupts glutamatergic N-methyl-d-aspartate receptor (NMDAr) antagonist-induced amnesia, indicating that novelty is necessary for such an amnestic effect. While there are reports that novelty-related release of opioids cause amnesia, no study has addressed whether the amnestic effect of NMDAr antagonists involve opioid mechanisms. In this study we investigated whether pharmacological manipulation of the opioid system immediately after context pre-exposure alters the amnestic effect of arcaine, a NMDAr antagonist. Adult male Wistar rats were habituated (pre-exposed) to a fear conditioning training apparatus or to a different context (open field). Immediately after pre-exposure, animals were injected with saline or naloxone (0.5 mg/kg, i.p.) or anti-beta-endorphin antibody (1:500, i.c.v.). Forty eight hours after pre-exposure session, all animals were subjected to fear conditioning acquisition protocol and saline or arcaine (30 mg/kg, i.p.) was administered immediately after training. Testing was carried out 24 h later, and freezing responses due to re-exposure to the training apparatus were recorded. Pre-exposure to the training apparatus prevented the impairment of memory induced by post-training arcaine. Administration of naloxone or anti-beta-endorphin antibody, immediately after pre-exposure to the training apparatus, reinstated the amnesic effect of post-training arcaine. The results suggest that endogenous opioid mechanisms are involved in the pre-exposure-induced loss of the amnestic effect of arcaine.     

A fresh look at the predictors of naming accuracy and errors in Alzheimer's disease

In recent years, a considerable number of studies have tried to establish which characteristics of objects and their names predict the responses of patients with Alzheimer's disease (AD) in the picture-naming task. The frequency of use of words and their age of acquisition (AoA) have been implicated as two of the most influential variables, with naming being best preserved for objects with high-frequency, early-acquired names. The present study takes a fresh look at the predictors of naming success in Spanish and English AD patients using a range of measures of word frequency and AoA along with visual complexity, imageability, and word length as predictors. Analyses using generalized linear mixed modelling found that naming accuracy was better predicted by AoA ratings taken from older adults than conventional ratings from young adults. Older frequency measures based on written language samples predicted accuracy better than more modern measures based on the frequencies of words in film subtitles. Replacing adult frequency with an estimate of cumulative (lifespan) frequency did not reduce the impact of AoA. Semantic error rates were predicted by both written word frequency and senior AoA while null response errors were only predicted by frequency. Visual complexity, imageability, and word length did not predict naming accuracy or errors.     

Mindfulness Training and Classroom Behavior Among Lower-Income and Ethnic Minority Elementary School Children

This field intervention trial evaluated the effect of a 5-week mindfulness-based curriculum on teacher-ratings of student classroom behavior at a Richmond, CA public elementary school, and examined if the addition of more sessions provided added benefit to student outcomes. Seventeen teachers reported on the classroom behaviors of 409 children (83 % enrolled in a California free lunch program and 95.7 % ethnic minority) in kindergarten through sixth grade at pre-intervention, immediate post-intervention, and 7 weeks post-intervention. Results showed that teachers reported improved classroom behavior of their students (i.e., paying attention, self-control, participation in activities, and caring/respect for others) that lasted up to 7 weeks post-intervention. Overall, improvements were not bolstered by the addition of extra sessions, with the exception of paying attention. The implications of this study are limited due to the lack of a mindfulness program-naïve control group, yet findings suggest that mindfulness training might benefit teacher-based perceptions of improved classroom behavior in a public elementary school, which has practice implications for improving the classroom learning environment for lower-income and ethnically-diverse children.     

Estructura social y conductas de saludo en dos especies de babuinos

Resumen

Independientemente de la proximidad taxonómica, dentro del género Papio existen distintas formas de estructura social. Al mismo tiempo se encuentran diferencias cuantitativas y cualitativas en los repertorios de conducta de las dos especies estudiadas (P. hamadryas y P. cynocephalus), concretamente en los movimientos de salutación.

Se buscó una relación entre dichas estructuras sociales y los respectivos movimientos de saludo que aparecían como característicos de cada especie. La estructura social podría modificarse rápidamente por las presiones ambientales, por lo que serían necesarios nuevos repertorios conductuales en consonancia con el cambio y al mismo tiempo que éste.

Al menos en niveles tan altos de la escala evolutiva, los individuos son capaces de organizar sus conductas según su posición respecto al conjunto del grupo y adecuarlas para acceder a los distintos nichos sociales. Por tanto, no es posible adscribir a la conducta una función exclusiva, sino que dependería de la idiosincrasia individual y de los distintos escalones sociales característicos de una determinada estructura social.     

Cross-cultural generalizability of the Personality and Role Identity Structural Model (PRISM): Implications for trait and cultural psychology

The cross-cultural generalizability of the Personality and Role Identity Structural Model (PRISM; Wood & Roberts, 2006) was tested in the United States, Mexico, Malaysia, China, and Japan. Participants rated their general and role identities, as defined by the PRISM, using Big Five trait adjectives, then rated their personality states (i.e., role experiences) in various roles in multiple daily interactions for 14 days. Structural predictions based on the PRISM were supported in all five cultures. Cultural differences were limited and did not reflect cultural differences in individualism–collectivism, dialecticism, or cultural tightness. The results supported the cross-cultural generalizability of the PRISM and the merits of contextualized trait measures in the prediction of role experiences. Implications for trait and cultural psychology are discussed.     

Larger plantar flexion torque variability implies less stable balance in the young: An association affected by knee position

The present study examined the association between plantar flexion torque variability during isolated isometric contractions and during quiet bipedal standing. For plantar flexion torque measurements in quiet stance (QS), subjects stood still over a force plate. The mean plantar flexion torque level exerted by each subject in QS (divided by 2 to give the torque due to a single leg) served as the target torque level for right leg force-matching tasks in extended knee (KE) and flexed knee (KF) conditions. Muscle activation levels (EMG amplitudes) of the triceps surae and mean, standard deviation and coefficient of variation of plantar flexion torque were computed from signals acquired during periods with and without visual feedback. No significant correlations were found between EMG amplitudes and torque variability, regardless of the condition and muscle being analyzed. A significant correlation was found between torque variability in QS and KE, whereas no significant correlation was found between torque variability in QS and KF, regardless of vision availability. Therefore, torque variability measured in a controlled extended knee plantar flexion contraction is a predictor of torque variability in the anterior-posterior direction when the subjects are in quiet standing. In other words, larger plantar flexion torque variability in KE (but not in KF) implies less stable balance. The mechanisms underlying the findings above are probably associated with the similar proprioceptive feedback from the triceps surae in QS and KE and poorer proprioceptive feedback from the triceps surae in KF due to the slackening of the gastrocnemii. An additional putative mechanism includes the different torque contributions of each component of the triceps surae in the two knee angles. From a clinical and research standpoint, it would be advantageous to be able to estimate changes in balance ability by means of simple measurements of torque variability in a force matching task.     

Syndromes or symptoms in the assessment of aphasic patients?

The procedure generally used to diagnose aphasic patients consists of classifying them in one of the classic syndromes on the basis of the analysis of their symptoms. However, this taxonomy has several important problems, the main one being that it does not take into account the variability of aphasic patients, as there are many more disorder profiles than those included in the syndromes. In order to test the homogeneity of a sample of patients diagnosed with the classic taxonomy, 15 aphasic patients (5 Broca, 5 Wernicke and 5 Conduction) and 5 healthy controls were tested with nine comprehension and production tasks. Participants were aged 38 to 81 years old. The results indicate the existence of great variability in patients labeled with the same diagnosis, as revealed by the differences in within-group scores in each task, and a limited adjustment to the expected profile, with some patients showing symptoms allegedly corresponding to other syndromes. Our results call attention to the need to study each patient individually and interpret their disorders regardless of the syndromes.     

Professional Journeys of International Medical Graduates in Quebec: Recognition,Uphill Battles,or Career Change

In Quebec and Canada, immigration policies are designed to attract “the best and the brightest.” Once migration occurs, however, the “brain waste” is challenging. This research focuses on the professional trajectories of international medical graduates (IMG) who migrate to Quebec. The main goal is to understand why certain individuals of a similar occupational group can easily access the doctoral profession while others cannot. Following a qualitative approach, and stemming from IMGs’ perspectives, this article explores the interplay of economic, social, and symbolic resources in a context of highly fragmented institutional resources and protectionism. We are critical of the individual-centered approaches that ignore social norms and constraints. If migrants are free to choose their paths and manner of integration, the “human capital” approach is limited in explaining the heterogeneous pathways within the same professional group. The current structure for professional recognition places unusual constraints on IMGs, whereby some encounter more obstacles than others. The “battle” for professional recognition takes shape in a highly competitive context, one which—although presented as a neutral process—is underlain with ideological, relational, and subjective currents.     

From an Existentialist God to the God of Existence. The Theological Conjectures of Hans Jonas

Hans Jonas developed in ‘Past and Truth’ (1991) a demonstration of the existence of God based on the ‘truth of past things’. And in ‘The Concept of God after Auschwitz’ (1984) he created a new myth of divine self-alienation in order to take away God’s responsibility for human misery. Both these texts were conceived as an alternative to a more Hegelian, objective idealist perspective on theology. This article shows that Jonas’s alternative does not fully succeed in this respect because his arguments bring him back to an idealist perspective. His proof of God is revisited and explained using new insights recently developed by Robert Spaemann, whose interpretation of the proof makes it clear that many important critics of Jonas are too quick to reject his claims. The arguments of Jonas now seem to show a new strength even though they still fail to give an alternative to an objective idealist theological framework.