Short-term effects of postnatal manipulation on central beta-adrenoceptor transmission

Neonatal handling is known to induce long-lasting changes in behavioral and neuroendocrine responses to stress. Since the central noradrenergic system participates in the adaptive responses to stressful conditions we have analyzed the effects of postnatal handling on beta-adrenoceptor binding sites and isoprenaline- and forskolin-stimulated cyclic AMP accumulation in cerebral cortex, hippocampus and cerebellum of rats at 1 and 3 months of age. Handled animals showed reduced emotional reactivity and lower ACTH and corticosterone secretion after stress. Binding studies using [(3) H]CGP12-177 revealed increased beta-adrenoceptor binding sites in handled rats in cerebellum and cerebral cortex with no changes in hippocampus, and decreased affinity in all cerebral regions. Handling reduced basal levels of cyclic AMP in hippocampus and cerebellum but not in cerebral cortex. The concentration-response curves of cyclic AMP to isoprenaline were displaced to the right in cerebellum of handled rats without differences in Emax; however, Emax was significantly reduced in cerebral cortex and hippocampus. Direct stimulation of the catalytic subunit of adenylyl cyclase by forskolin reduced the efficiency in hippocampus and cerebellum, but not in cerebral cortex of handled animals. It is concluded that neonatal handling reduces the binding properties of beta-adrenoceptor and its primary biochemical responses in the young rat brain, which may account for the reduced responsiveness to stress attained in the handled rats, and may explain the persistence of the effect. The present study emphasizes the role of the central noradrenergic system in modulating the behavioral and neurendocrine responses to neonatal handling.     

The Social Phobia and Anxiety Inventory: Reliability and Validity in an Adolescent Spanish Population

The objective of this study is to examine the factor structure and psychometric properties of the SPAI in a sample of adolescent Spaniards. The results obtained support the use of the correlated two-factor SPAI subscales and indicate high coefficient alpha values for the SPAI subscales. The results provide support for the use of the SPAI in an adolescent population in a non-English-speaking country. Both exploratory and confirmatory factor analyses of the Social Phobia subscale showed a four-factor structure, instead of a five-factor dimension, as suggested by previous studies. Effects for gender and age and gender interaction were found. Limitations and suggestions for future research are discussed.     

Psychometric appraisal of Eysenck's revised Psychoticism scale: a cross-cultural study

Psychometric characteristics of Eysenck's revised P scale were studied in a cross-cultural research. The Spanish version of the Eysenck Personality Questionnaire-Revised (EPQ-R) was administered to a Spanish sample of 527 males and 583 females. Maximum-likelihood factor analyses of the item intercorrelations and Direct Oblimin rotations of the extracted factors were carried out separately for males and females. The results revealed four factors identified as psychoticism (P), extraversion (E), neuroticism (N) and dissimulation/conformity (L). Internal consistency and test–retest reliability coefficients were satisfactory and very similar to the ones found in the original study. Skewness and kurtosis of the P scale distribution were closer to normal than on the original British revised P scale.     

Simulations of schedule-controlled behavior

A computer model that simulates the patterns of responding of infrahuman subjects under several schedules of reinforcement is described. The model is dynamic in that it continuously assesses the values of several interacting variables that are, in turn, affected by simulated environ-mental events that are scheduled by a procedure program. The data generated by the computer model, including cumulative records, closely conform to reported experimental data. The results indicate that computer simulations are a very useful tool for developing quantitative theories of operant behavior.     

The identity impact of witnessing selective incivility: A study of minority ethnic professionals

We examine how minority ethnic employees account for witnessing selective incivility to ethnically similar others. Our study is based on qualitative interviews with British Asian employees – the majority who witnessed incivility directed towards migrant Asian employees working for the same company. Our findings indicate that, for those whose minority ethnic identity was of central importance, witnessing selective incivility towards others from a similar ethnic background can be perceived as an identity threat. We provide insights into three identity work strategies undertaken by witnesses of selective incivility, while illuminating how minority ethnic identity shapes the way witnesses' respond to selective incivility in the workplace.     

Reasonable expectations,moral responsibility,and empirical data

Philosophical Studies - Many philosophers think that a necessary condition on moral blameworthiness is that the wrongdoer can reasonably be expected to avoid the action for which she is blamed....     

Young adults' partner preferences and parents' in-law preferences across generations,genders, and nations

To examine cultural, gender, and parent–child differences in partner preferences, in eight countries undergraduates (n = 2,071) and their parents (n = 1,851) ranked the desirability of qualities in someone the student might marry. Despite sizable cultural differences—especially between Southeast Asian and Western countries—participants generally ranked kind/understanding (reflecting interpersonal communion) highest, and intelligent and healthy (reflecting mental/physical agency) among the top four. Students valued exciting, attractive partners more and healthy, religious partners less than parents did; comparisons with rankings by youth in 1984 (i.e., from the parents' generation) suggested cohort effects cannot explain most parent–child disagreements. As evolutionary psychology predicts, participants prioritized wives' attractiveness and homemaker skills and husbands' education and breadwinner skills; but as sociocultural theory predicts, variations across countries/decades in gendered spousal/in-law preferences mirrored socioeconomic gender differences. Collectively, the results suggest individuals consider their social roles/circumstances when envisioning their ideal spouse/in-law, which has implications for how humans’ partner-appraisal capabilities evolved.     

Metacognitions in patients with hallucinations and obsessive-compulsive disorder: the superstition factor

On the basis of the analogy between intrusive thoughts and auditory hallucinations established by Morrison et al. [(1995). Intrusive thoughts and auditory hallucinations: a cognitive approach. Behavioural and Cognitive Psychotherapy, 23, 265-280], the present work compares the metacognitive beliefs and processes of five groups of patients (current hallucinators, never-hallucinated people with a diagnosis of schizophrenia, recovered hallucinators, obsessive-compulsive disorder (OCD) patients, and a clinical control group) and a non-clinical group. The results show that of the five metacognitive factors considered in this study, two were found to be different in the current hallucinators group in comparison to any other group in the design. Likewise, it is found that the metacognitive beliefs of the current hallucinators coincide with those of the OCD patients in various factors, particularly that relating to superstition, and this is interpreted as lending support to the model of Morrison et al. (1995). Furthermore, the results are discussed in the light of existing research on Thought-Action Fusion, stressing the role that may be played by superstitious beliefs and magical thinking in auditory hallucinations and OCD.