Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

The AT₄ ligands, angiotensin IV and LVV-hemorphin 7, elicit robust effects on facilitating memory by binding to a specific site in the brain historically termed the angiotensin AT₄ receptor. The identification of the AT₄ receptor as insulin-regulated aminopeptidase (IRAP) is controversial, with other proteins speculated to be the target(s) of these peptides. In this study we have utilized IRAP knockout mice to investigate IRAP in the brain. We demonstrate that the high-affinity binding site for angiotensin IV is absent in IRAP knockout mice brain sections in parallel with the loss of IRAP immunostaining, providing irrefutable proof that IRAP is the specific high-affinity binding site for AT₄ ligands. However, our characterization of the behavioural phenotype of the IRAP knockout mice revealed a totally unexpected finding. In contrast to the acute effects of IRAP inhibitors in enhancing memory, deletion of the IRAP gene resulted in mice with an accelerated, age-related decline in spatial memory that was only detected in the Y maze paradigm. Moreover, no alterations in behaviour of the IRAP knockout mice were observed that could assist in elucidating the endogenous substrate(s). Our results highlight the importance of analysing the behavioural phenotype of knockout mice across different ages and in distinct memory paradigms.     

Barriers perceived by teachers at work, coping strategies, self-efficacy and burnout

This study examines the relationships among stressors, coping strategies, self-efficacy and burnout in a sample of 724 Spanish primary and secondary teachers. We understood stressors as barriers perceived by teachers that interfere with their work meeting learning objectives and which cause them stress and burnout. An analysis of teacher responses using hierarchical regression revealed that pedagogical barriers had significant positive effects on the burnout dimensions. Furthermore, the results show not only the moderator role played by coping strategies in the pedagogical barriers-burnout dimensions relationship, but also the association between self-efficacy and the coping strategies used by teachers. Practical implications are discussed.     

On the mental representations originating during the interaction between language and vision

The interaction between vision and language processing is clearly of interest to both cognitive psychologists and psycholinguists. Recent research has begun to create understanding of the interaction between vision and language in terms of the representational issues involved. In this paper, we first review some of the theoretical and methodological issues in the current vision–language interaction debate. Later, we develop a model that attempts to account for effects of affordances and visual context on language-scene interaction as well as the role of sensorimotor simulation. The paper addresses theoretical issues related to the mental representations that arise when visual and linguistic systems interact.     

Phonological mediation in visual masked priming: evidence from phonotactic repair

In a series of 4 experiments, the authors show that phonological repair mechanisms, known to operate in the auditory modality, are directly translated in the visual modality. This holds with the provision that printed stimuli are presented for a very brief duration and that the effect of phonological repair is tested after a delay of some 100 ms has elapsed after that presentation. The case of phonological repair chosen to exemplify the parallelism between print and speech is the prosthesis of /e/ in utterances beginning with /s/ followed by a consonant in Spanish. Native speakers of Spanish hear a prothetic /e/ in auditorily presented pseudowords such as special (/speojal/, derived from "especial") as well as stuto (/stuto/, derived from "astuto"). It is shown here that they also hear that same vowel /e/ when presented with the printed pseudowords "special" and "stuto." This finding of a phonological repair effect in print has implications for the issue of phonological activation from print, as well as for the prelexical locus and mandatory nature of phonological repair mechanisms in general.     

Body weight increase in expectant males and helpers of cotton-top tamarin (Saguinus oedipus): a symptom of the Couvade syndrome?

In the cooperative breeding system of cotton-top tamarin (TCB; Saguinus oedipus) males gain weight during the last months of pregnancy of their partners as a way to cope with energy costs of reproduction. This phenomenon was described only in humans as a symptom of . As after infants' birth, TCB male and female helpers lose weight, the same as fathers do, it might be expected that previously, they also gain weight. In 8 groups of TCB, we explored body weight changes of the three categories of individuals, in periods of six months, under three different reproductive conditions: control (no pregnancy and without offspring), pregnancy (pregnancy and without offspring), and raising (with offspring). We found that across pregnancy, TCBs increase their weight in the last trimester of that period while across breeding TCBs reduce their weight in the first trimester. Expectant males and also helpers could be preparing during pregnancy in relation to the weight losses they experience when raising their young.     

Learning approaches, self-regulation and achievement in three European universities

The current study seeks to analyze the relationship between learning approaches, self-regulation and performance. Data are gathered from three public European universities, one from the UK (University of Wales Institute, Cardiff) and two from Spain (Universities of Almeria and Granada). Two self-report measurements were used to collect information, the R-SPQ-2F questionnaire and the IATLP Scales. Results indicate that learning approaches are related to self-regulation and to academic performance. Different relationships with learning approaches are obtained depending on the type of performance analyzed (conceptual, procedural, attitudinal), which may account for divergent conclusions in other research studies. New lines of research are proposed based on the conclusions.     

Child sexual abuse coping and long term psychological adjustment

The aim of the study was to analyze the consequences of Child Sexual Abuse (CSA) on the psychological adjustment of university students, as well as the way in which several avoidance and approach coping strategies affect that adjustment. The sample comprised 1162 students from the University of Granada. Data about CSA was obtained from a questionnaire developed with this aim. We used the How I Deal with Things Scale of Burt and Katz to evaluate coping strategies, whereas depression and self-esteem were assessed with the Beck Depression Inventory and the Rosenberg Self-Esteem Scale, respectively. Subjects who were victims of CSA showed significantly higher scores on depression and lower scores on self-esteem. An analysis of coping strategies revealed that only the use of avoidance strategies was related to psychological adjustment. Subjects who used these strategies obtained higher scores on depression and lower scores on self-esteem. These results confirm the idea of CSA as a risk experience that can affect victims' psychological adjustment, to a greater or lesser extent, according to the coping strategy employed.     

Risk factors for addictive disorders: a discriminant analysis on 374 addicted and 513 nonpsychiatric participants

Many common risk factors have been described in addictive disorders. Little is known about factors' respective contributions to discrimination of addicted and nonaddicted participants. Two large samples were compared including 513 nonpsychiatric participants and 374 addicted participants meeting the DSM-IV criteria for eating disorders, alcohol, or substance dependence. Twenty-six risk factors were assessed by interview or self-rating scales. A discriminant analysis determined the respective weight of each risk factor. One discriminant function emerged and characterized a depressive dimension. The results suggest that the different risk factors described in addiction could be related to a depressive dimension.     

The Quality of Home Environment in Brazil: An Ecological Model

Based on Bronfenbrenner's (1999) ecological perspective, a longitudinal, prospective model of individual differences in the quality of home environment (Home Observation for Measurement of the Environment—HOME) was tested in a sample of 179 Brazilian children and their families. Perinatal measures of family socioeconomic status (SES) and child birth weight had direct effects on HOME at preschool age. As either family SES or child birth weight increased, HOME also increased through diminished emotional distress in the mother a month following childbirth. SES had a negative effect on number of children in the household, which in turn had a long-term negative impact on HOME. Compared to mothers who had reported not to plan their pregnancy, those who did were more likely to have fewer children, to report more spouse support during childbearing, and to show less emotional distress a month after childbirth, all of which also influenced HOME at preschool age. These findings are discussed in light of the broader socio-ecological Brazilian context, with direct implications to clinical practice aimed at improving the quality of home environment.     

Personality, gender and violent criminality in prison inmates

The Antisocial Personality Questionnaire developed by Blackburn and Fawcett (1999) has shown adequate reliability and validity in studies of male offenders interned in psychiatric hospitals. This paper provides data on the APQ collected from a sample of offenders (males and females) without any diagnosed mental illness. The sample was made up of 216 offenders (108 males and 108 females) confined in Spanish prisons. We analyzed the psychometric properties of the instrument and we also examined differences in personality as a function of gender and type of crime (violent vs. non-violent). Results support the reliability of the APQ scales as well as the structure proposed by Blackburn. Additionally, we selected items that discriminate between offenders convicted for violent and non-violent crimes; when these items are factorized, a three-factor structure emerges, resembling Eysenck's model.