Clinical Characterization and Risk Profile of Individuals Seeking Genetic Counseling for Hereditary Breast Cancer in Brazil

Hereditary breast cancer (HBC) accounts for 5–10% of breast cancer cases and it significantly increases the lifetime risk of cancer. Our objective was to evaluate the sociodemographic variables, family history of cancer, breast cancer (BC) screening practices and the risk profile of cancer affected or asymptomatic at-risk women that undergo genetic counseling for hereditary breast cancer in public Brazilian cancer genetics services. Estimated lifetime risk of BC was calculated for asymptomatic women using the Gail and Claus models. The majority of women showed a moderate lifetime risk of developing BC, with an average risk of 19.7% and 19.9% by the Gail and Claus models, respectively. The average prior probability of carrying a BRCA1/2 gene mutation was 16.7% and overall only 32% fulfilled criteria for a hereditary breast cancer syndrome as assessed by family history. We conclude that a significant number of individuals at high-risk for HBC syndromes may not have access to the benefits of cancer genetic counseling in these centers. Contributing factors may include insufficient training of healthcare professionals, disinformation of cancer patients; difficult access to genetic testing and/or resistance in seeking such services. The identification and understanding of these barriers is essential to develop specific strategies to effectively achieve cancer risk reduction in this and other countries were clinical cancer genetics is not yet fully established.     

Reconsolidation of declarative memory in humans

The reconsolidation hypothesis states that a consolidated memory could again become unstable and susceptible to facilitation or impairment for a discrete period of time after a reminder presentation. The phenomenon has been demonstrated in very diverse species and types of memory, including the human procedural memory of a motor skill task but not the human declarative one. Here we provide evidence for both consolidation and reconsolidation in a paired-associate learning (i.e., learning an association between a cue syllable and the respective response syllable). Subjects were given two training sessions with a 24-h interval on distinct verbal material, and afterward, they received at testing two successive retrievals corresponding to the first and second learning, respectively. Two main results are noted. First, the first acquired memory was impaired when a reminder was presented 5 min before the second training (reconsolidation), and also when the second training was given 5 min instead of 24 h after the first one (consolidation). Second, the first retrieval proved to influence negatively on the later one (the retrieval-induced forgetting [RIF] effect), and we used the absence of this RIF effect as a very indicator of the target memory impairment. We consider the demonstration of reconsolidation in human declarative memory as backing the universality of this phenomenon and having potential clinical relevance. On the other hand, we discuss the possibility of using the human declarative memory as a model to address several key topics of the reconsolidation hypothesis.     

Learned preferences induced by electrical stimulation of a food-related area of the parabrachial complex: effects of naloxone

Electrical stimulation of the External Lateral Parabrachial Subnucleus (LPBe), a food-related area, induced behavioral preferences for associated stimuli in a taste discrimination learning task. Although this stimulation appeared to be ineffective to elicit standard lever press self-stimulation, it induced place preference for one of two training compartments of a rectangular maze in which animals (adult male Wistar rats) received concurrent electrical brain stimulation. In subjects that consistently showed a preference behavior in different trials, administration of the opioid antagonist naloxone (4 mg/ml/kg) blocked concurrent learning when the test was made in a new maze but not in the same maze in which animals had learned the task. These results are discussed in terms of the possible participation of the LPBe subnucleus in different natural and artificial brain reward systems.     

Impact of parenting styles on adolescents' self-esteem and internalization of values in Spain

The relationship of parenting styles with adolescents' outcomes was analyzed within a sample of Spanish adolescents. A sample of 1456 teenagers from 13 to 16 years of age, of whom 54.3% were females, reported on their parents' child-rearing practices. The teenagers' parents were classified into one of four groups (authoritative, authoritarian, indulgent, or neglectful). The adolescents were then contrasted on two different outcomes: (1) priority given to Schwartz's self-transcendence (universalism and benevolence) and conservation (security, conformity, and tradition) values and (2) level of self-esteem (appraised in five domains: academic, social, emotional, family and physical). The results show that Spanish adolescents from indulgent households have the same or better outcomes than adolescents from authoritative homes. Parenting is related with two self-esteem dimensions--academic and family--and with all the self-transcendence and conservation values. Adolescents of indulgent parents show highest scores in self-esteem whereas adolescents from authoritarian parents obtain the worst results. In contrast, there were no differences between the priority given by adolescents of authoritative and indulgent parents to any of the self-transcendence and conservation values, whereas adolescents of authoritarian and neglectful parents, in general, assign the lowest priority to all of these values.     

Quantum Mechanics and the Plight of Physicalism

The literature on physicalism often fails to elucidate, I think, what the word physical in physicalism precisely means. Philosophers speak at times of an ideal set of fundamental physical facts, or they stipulate that physical means non-mental, such that all fundamental physical facts are fundamental facts pertaining to the non-mental. In this article, I will probe physicalism in the very much tangible framework of quantum mechanics. Although this theory, unlike “ideal physics” or some “final theory of non-mentality”, is an incomplete theory of the world, I believe this analysis will be of value, if for nothing else, at least for bringing some taste of physical reality, as it were, back to the debate. First, I will introduce a broad characterization of the physicalist credo. In Sect. 2, I will provide a rather quick review of quantum mechanics and some of its current interpretations. In Sect. 3, the notion of quantum non-separability will be analyzed, which will facilitate a discussion of the wave function ontology in Sect. 4. In Sects. 5 and 6, I will explore competing views on the implications of this ontology. In Sect. 7, I will argue that the prior results, based on a thoroughly realist interpretation of quantum mechanics, support only a weak version of non-reductive physicalism.     

Depressive Realism: Wiser or Quieter?

The Psychological Record - Depressive realism consists of the lower personal control over uncontrollable events perceived by depressed as compared to nondepressed individuals. In this article, we...     

Three dimensions of coping and a look at their evolutionary origin

Serious problems persist concerning the conceptualization and measurement of the coping construct. This study examines the properties and factor structure of the COPE questionnaire, one of the most widely used instruments to measure coping, in a sample of 471 patients. A series of exploratory factor procedures are applied at the item- and scale-level, and the resulting solutions are tested both by their congruence with previously published structures and by confirmatory techniques. Our finding of three robust, generalizable, and parsimonious second-order dimensions—Engagement, Disengagement, and Help-Seeking—challenges the original structure. The results are discussed from an evolutionary perspective, on the assumption that the recognition of coping as the activation of vestigial defenses may make a substantial contribution to clarifying its functions and organization.     

Exploring Ethnic,Gender, and Sexual Orientation Variables in Supervision: Do They Really Matter?

This study explored discussions of cultural variables in supervision and their influence on supervisory satisfaction and working alliance. Results indicated limited discussions occurred, but when these discussions did occur, supervisees reported enhanced supervisory working alliance and increased satisfaction with supervision. These findings highlight the importance of supervisors initiating discussions of cultural variables. Este estudio exploró discusiones sobre variables culturales y su influencia en la satisfacción y alianza de supervisión. Los resultados indicaron discusiones limitadas, pero cuando estas ocurrieron, los supervisados reportaron un aumento en la alianza de trabajo y satisfacción con la supervisión. Estos resultados hacen notable la importancia de que los supervisores inicien discusiones sobre los variables culturales.     

Mixed models,random utilities,and the triangle inequality

A new probabilistic binary choice model, which we call the mixed model is proposed. This model is used to give an interpretation of probabilistic choice behavior in terms of complete and partial orders. The model is used as a guide to disprove Jacob Marschak's conjecture that the binary random utility model is equivalent to the triangle inequality. Another result is presented concerning the relation between moderate stochastic transitivity and the triangle inequality.     

Acute alcohol intoxication paired with appetitive reinforcement: effects upon ethanol intake in infant rats

A recent study suggested that infant rats process alcohol odor and/or taste during acute ethanol intoxication probably due to ethanol elimination via respiration and salivation. The present set of experiments was meant to analyze the possibility that this orosensory processing may act as a conditioned stimulus when an appetitive reinforcer is paired with the state of intoxication. In the first experiment it was observed that intragastric administration of a mildly intoxicating ethanol dose (1.5 g/kg), paired during postabsorptive time intervals with oral infusion of sucrose, was sufficient to promote a significant preference to ethanol. In Experiment 2 different doses of ethanol were either paired or explicitly unpaired with sucrose administration. The result reported in Experiment 1 was replicated and it was observed that a higher dose (3.0 g/kg) unpaired with the reinforcer resulted in alcohol aversions in terms of alcohol consumption patterns. However, when the reinforcer was paired with this dose, the aversion was inhibited. Finally, in the third experiment results indicated that preexposure to alcohol odor eliminates sucrose-conditioned alcohol preferences. These results indicate that, in physiologically immature rats, alcohol preference can be regulated by prior associative experiences involving the state of intoxication and consequences internal and/or inherent to this state.