Comparative clinicogenetic study of schizophrenic psychoses

The author diagnoses 350 carefully selected schizophrenic subjects, their parents and their siblings during parallel studies using three different clinical classification systems and analyzes the results by multiple threshold analysis and the multifactorial inheritance model. The results suggest that, of the three classifications the author studied, Leonhard's and Sneshnewski's system yield relatively homogeneous subgroups; this indicates the future significance of these nosological systems for the planning of biopsychiatric research.     

Hyperlexia and a variant of hypergraphia

A patient with hyperlexia and hypergraphia is described. The unusual co-occurrence of these two abilities is discussed. Hyperlexia may provide a useful marker to guide educational programming.     

Microcomputer-assisted relaxation

The present pilot study was designed to test the effectiveness of a microcomputer program developed by the authors to induce relaxation and focused attention, which are common to most clinical stress-reduction and hypnotic procedures. A nonclinical sample of 20 adults used the program on an APPLE IIc computer in two 30-min. sessions in a within-subjects design. Repeated measures analyses of variance showed significant decreases in the Spielberger State Anxiety Scale and on a visual analog anxiety scale. Limitations and implications of the study are discussed.     

Compliance with homework to employ self-instructions in controlling ice water pain: an analogue to counseling

40 women were taught to use self-statements to cope with pain caused by ice water. The trainer used four different strategies for reassigning a homework task of using self-statements to cope with pain produced by immersing one hand in ice water. The strategies were equally effective in eliciting compliance with the homework assignment.     

The effects of child abuse as seen in adults: George Orwell

The author presents the case of a patient who showed the massive defensive effects seen in people who were abused in childhood. These effects are similar to those described in George Orwell's 1984 and in his autobiographical writings: denial and "doublethink"; masochistic submission to the tormentor; turning of anger against the self and loving "Big Brother"; identifying with the abuser and tormenting others; a burgeoning of anal mechanisms and obsessive phenomena that results in a massive isolation of affects; excessive emotional control alongside outbursts of rage. The interference with memory and emotions compromises identity and humanity. The unforseeable evolution of innate gifts in a child sometimes permits a partial transcendence of these crippling defenses, as Orwell partially transcended what appears to have been the emotional deprivation of his childhood and what he felt to have been the abuse of his schoolboy years.     

Electrophysiological correlates of semantic features

Analyses of averaged auditory evoked responses to a list of 10 positive and 10 negative words led to the identification of a restricted region in the brain response which reliably discriminated between words differing in the semantic features positive and negative. These data support the view that word meanings are composed of more basic components or features and are not stored simply as dictionary items in the brain.     

Analytic,synthetic, abstracting,and word-class-defining aspects of verbal mother-child interactions

Phenomena of language teaching and learning in the course of verbal interactions between one mother and her daughter were analyzed. The daughter was between 18 and 27 months old during the recordings, and her utterance length ranged from 1,5 to 4,0 morphemes. Twenty hours of interactions were analyzed and the emphasis was placed upon sequential aspects and mathemagenic features of the conversations. It was demonstrated that the mother performs much analytic, synthetic, abstracting, and word-class-defining work during these verbal interactions. These maternal instructional activities seem to lead not only to the child's learning of language rules but also to her employment of the abstracting, analytical, and synthetic methodology. It is concluded that the main explanatory focus has to be on the mother in the attempts to explain language transmission and acquisition. Basic similarities to other instructional/skill training situations are suggested. Neither extraordinary complex cognitive nor innate linguistic capacities need to be assumed to explain the phenomena in question.     

Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.