性别与阿尔茨海默病相关性的研究进展

阿尔茨海默病（AD）是以近期记忆障碍为主要临床症状,以老年斑及神经纤维缠结为主要病理改变的进行性神经变性疾病。目前发现男女患病率有明显差异,女性患病率是男性的1．5倍～3倍,这可能是由于绝经后妇女体内雌激素不足增加了AD的易感性,而男性血清总睾酮降低,能使AD患者病情恶化。     

Unwanted Identities: A Key Variable in Shame–Anger Links and Gender Differences in Shame

The present study examined the role that unwanted identities play in accounting for extant findings concerning gender differences in shame-proneness. The construct of unwanted identities was also used to explain why powerful associations have been found between shame and anger. College students (48 men, 84 women) rated their feelings of shame, guilt, anger, and unwanted identities in response to the TOSCA-2 scenarios, known to yield robust gender differences in shame, and to new scenarios, meant to be more threatening to men's than women's identities. Even after accounting for shared variance between shame and guilt, evidence supported the conclusion that women's greater shame-proneness than men's could be an artifact, reflecting the more threatening nature of previous situations to women's identities. Mediational analyses also confirmed that unwanted identities elicit shame, which, in turn, is a powerful instigator of anger. Discussion focuses on inconsistencies between the present results and expectations based on previous theory and research.     

An evaluation of estimation data collection to trial‐by trial data collection during discrete trial teaching

There are many data collection procedures used during discrete trial teaching including first‐trial data collection, probe data, trial‐by‐trial data collection, and estimation data. Continuous, or trial‐by‐trial data collection, consists of the interventionist collecting data on learner behavior on each trial. Estimation data consists of the interventionist estimating learner performance after a teaching session using a rating scale. The purpose of the present study was to compare trial‐by‐trial data collection to estimation data collection during discrete trial teaching to teach children expressive labels. The data collection procedures were examined in terms of accuracy of data collection, efficiency of teaching (i.e., number of trials delivered per session), and rate of child acquisition of targets. Results of the adapted alternating treatment design replicated across three participants and multiple targets found estimation data collection to be as accurate as trial‐by‐trial data collection in determining mastery of targets. Estimation data collected by the interventionist was also found to be accurate when compared to the actual trial‐by‐trial data collected after the study concluded.     

Temporal dynamics of guilt: changes in the role of interpersonal and intrapsychic factors

Baumeister, Stillwell and Heatherton (1994) argue that guilt serves primarily interpersonal functions and take issue with more traditional intrapsychic accounts of guilty feelings, in which causality, responsibility, and blame are emphasized. We examined the validity of these claims by asking 198 college students to imagine that they destroyed the valued property of either their best friend or mother, under each of three conditions of causal responsibility (accidental, foreseeable, unjustifiably intended). They then rated the reactions they anticipated from the victim (anger, disappointment; change in impression of the perpetrator), their perceived blameworthiness, aspects of causality, and how guilty they would feel immediately after perpetrating the harm as well as an entire day later. Imagined guilt was curvilinearly related to responsibility at time 1, but linearly at time 2. Results suggest that people only weigh interpersonal concerns more heavily after time has elapsed, but that both factors integrally affect feelings of guilt. © 1997 John Wiley & Sons, Ltd.     

A randomized clinical trial of three prompting systems to teach tact relations

Prompts are commonly used during discrete trial teaching for individuals diagnosed with autism spectrum disorder (ASD). Three commonly used prompting systems include constant time delay, most-to-least prompting, and flexible prompt fading. Most of the research demonstrating the effectiveness of these three prompting strategies have been completed through the use of single subject experimental designs. Some within the field of behaviorally based approaches to ASD interventions have called for more randomized clinical trials of these approaches. The purpose of the present study was to compare these 3 prompting systems to teach tact relations for 27 individuals diagnosed with ASD through a randomized clinical trial without a control group with respect to pre–post responding, generalization, sessions to mastery, and responding during teaching. Overall, minimal differences were observed across the 3 systems. The results are discussed with respect to future research and clinical application of the methods evaluated.     

Institutional Approaches to Research Integrity in Ghana

Science and Engineering Ethics - Research misconduct (RM) remains an important problem in health research despite decades of local, national, regional, and international efforts to eliminate it....     

Conflict Transformation: Relinquishing or Maintaining Social Identity Among Former Loyalist Combatants in Northern Ireland

This study explored the accounts of former loyalist combatants now involved in conflict transformation, preventing violent extremism and peace-building work. To understand how former loyalist combatants negotiate their dramatic change in context and function, we analyzed accounts of peace building through thematic analysis. The themes demonstrated that conducting conflict transformation is expressively linked to former combatant identity. The themes also demonstrate that former combatants construct identity continuity by viewing their current transformative actions as an evolution of their militant activity during the Troubles. The article concludes on the implications of these identity maintenance strategies for former combatants and, more widely, what implications this has for other militants transitioning from conflict or extremism towards peace.