Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms

CB1 cannabinoid receptors are abundantly expressed in the brain, with large concentrations present in the hippocampus, a brain structure essential for memory processing. In the present study, we have investigated the possible modulatory role of the endocannabinoid system in the dorsal hippocampus upon the different phases of memory processing of an aversive task. AM251, a selective antagonist of CB1 receptors, and anandamide, an endogenous agonist of cannabinoid receptors, were bilaterally infused into the dorsal hippocampus of male Wistar rats either before training, immediately after training, or before test in the step-down inhibitory avoidance (IA) task. Results showed that pre-training infusion of CB1 drugs did not influence the acquisition of the task. In contrast, post-training infusion of the CB1 antagonist disrupted while the antagonist facilitated memory consolidation of IA. The post-training results demonstrate that memory consolidation depends on the integrity of the endocannabinoid system in the CA1 region of the dorsal hippocampus. While we still have no direct proof of endocannabinoids released there after an aversive task such as IA, these results suggests that (a) AM251 acts blocking the binding of endogenously released cannabinoids and (b) exogenously supplemented anandamide may be adding its contribution to the action of the endogenously released pool. Considering our data and the higher density of CB1 receptors present in the GABAergic interneurons, we propose them as the putative target of the endocannabinoid modulation of memory, a hypothesis that needs to be proven. In addition, pre-test infusion of the CB1 receptor antagonist facilitated while infusion of the agonist did not affect memory retrieval of IA. The completely opposite action of the same drug upon memory at the post-training (consolidation) and pre-test (recall) contexts suggests that some durable change took place in the CA1 region during the consolidation process that modified the logical attributes of the pharmacological response, i.e., the drug response changed from memory disruption to memory facilitation. A similar phenomenon was previously described by us in the M4 cholinergic muscarinic subsystem in the hippocampus for the same task (Diehl, F., Fürstenau, L. O., Sanchez, G., Camboim, C., de Oliveira Alvares, L., Lanziotti, V. B., et al. (2007). Facilitatory effect of the intra-hippocampal pretest administration of MT3 in the inhibitory avoidance task. Behavioral Brain Research, 177(2), 227-231), but the biological nature of such change in the local neural circuitry remains to be investigated.     

Overview: Sex Roles, Fertility and the Motherhood Mandate

Abstract: The centrality of motherhood to woman's identity is characterized as a mandate that is built into our social institutions as well as our psyches. This mandate is reflected in the assumptions of the models and methods of research in the psychology of women. An examination of the impact of the motherhood mandate is encouraged and complexities that must be reflected in research models and methods are underscored. These complexities include the need for (1) appreciation of the context of the phenomena studied; (2) interactionist approaches, including multivariate models and methods; and (3) a multidisciplinary perspective, including biological, psychological, social and structural levels of analysis. Two facets of the changing context having profound implications for the meaning of motherhood are reproductive freedom and voluntary childlessness.     

Cultural and communicative memories: contrasting Argentina’s 1976 coup d’état and the 2001 economic-political-social crisis

Studies on collective memory have recently addressed the distinction between cultural and communicative memory as a way to understand how the source of a memory affects its structure or form. When a groups’ memory is mediated by memorials, documentaries or any other cultural artifacts, collective memory is shaped by cultural memory. When it is based mostly in communication with other people, its source is communicative memory. We address this distinction by studying two recent events in Argentinean history: the 2001 economic-political-social crisis (communicative memory) and the 1976 coup (cultural memory). We also examine the political ideology and the type of memory involved in collective memory. The memory of the studied events may occur during the lifetime of the rememberer (Lived Memory) or refer to distant events (Distant Memory). 100 participants responded to a Free Recall task about the events of 2001 in Argentina. Narrative analysis allowed comparing these recalls with our 1976 study. Results show: 1) Cultural memories are more contextualised, more impersonal and less affective. 2) Communicative memories are more personal and affective. Study shows how collective memory form changes when it has a different prevalent source.     

Norms Affect Prospective Causal Judgments

People more frequently select norm-violating factors, relative to norm-conforming ones, as the cause of some outcome. Until recently, this abnormal-selection effect has been studied using retrospective vignette-based paradigms. We use a novel set of video stimuli to investigate this effect for prospective causal judgments—that is, judgments about the cause of some future outcome. Four experiments show that people more frequently select norm-violating factors, relative to norm-conforming ones, as the cause of some future outcome. We show that the abnormal-selection effects are not primarily explained by the perception of agency (Experiment 4). We discuss these results in relation to recent efforts to model causal judgment.     

Women's communication in Mexican organizations

This study attempts to derive a communication profile of women in Mexican organizations of the private sector. The questions that guided the study were the following: (1) Do women perceive their communication behaviors as similar to or different from those of men at their same organizational level? (2) If women do perceive differences, what is their nature? (3) Do perceived similarities to and differences from men vary by organizational level? Forty-five women in 14 Mexican organizations were intensively interviewed in the winter of 1980. The interviews were distributed equally at three organizational levels—secretarial, middle management, and upper management. It was found that women respondents perceive themselves to differ from men on 18 of 40 verbal and nonverbal communication variables. The average woman in this study perceived that verbally she is more courteous, cheerful, assertive, careful, likely to talk with males, self-confident, and directive than men, and that she expresses less agreement than men. Nonverbally, the average woman was found to look more at the eyes, smile more, give more attention to dress, be more punctual and flexible than men, and to be less rigid in posutre, touch less, invite co-workers to her home less, and take less work home. Organizational level differences were also found. The results are discussed in the light of the theoretical paradigms presented in the study.     

A Preliminary Investigation of the Sources of Information Used by Raters When Appraising Performance

Raters (N = 135) from six organizations completed a survey regarding the sources of information used when appraising an employee's performance. Results indicated that multiple sources of information are used, and that raters are active seekers, as well as passive recipients of performance information. The perceived usefulness of volunteered versus requested second-hand performance information was found to differ across the various information sources. Also, the number of sources of performance information used by a rater was found to be related to rater characteristics (e.g., job level, number of subordinates). Implications for performance appraisal research and practice are discussed.     

THE GLOBAL HEALTH BURDEN OF RAPE

Women's rights to be free from male violence are now recognized by the United Nations as fundamental human rights. Two parallel transformations in the understanding of rape have been central to the international effort to achieve this declaration. The first is increased recognition of the extent to which rape typically involves intimates. The second is the shift from regarding rape as a criminal justice matter towards an appreciation of its implications for women's health. The focus of this paper is the health burden of rape, which is addressed from the global perspective and includes discussion of its prevalence and psychological, sociocultural, somatic, and reproductive health consequences. Quantitative efforts to capture the relative economic impact of rape compared to other threats to women's health are also discussed. The paper concludes with an agenda for future research on rape that could enrich activists'efforts on behalf of women's health and development.