缺血修饰白蛋白在急性冠脉综合征中的临床应用研究

缺血修饰白蛋白(IMA),是一种反映急性心肌缺血的新的生化标志物,具有灵敏度高、阴性预测值高、时间窗窄等优点,是第一个经美国食品药品管理局(FDA)批准销售的心肌缺血标志物.近年来诸多研究证明缺血修饰蛋白在急性冠脉综合征的早期诊断、危险分层、指导治疗以及评估预后等方面具有重要临床意义,是目前较为理想的检测心肌缺血的生化标志物.本文就IMA的形成机制、检测方法及临床应用研究等方面作一综述.     

中国学生ETPSP误用现象及其与英语学习水平的关系

基于概念整合理论和范畴化原型理论,以对真实语料的统计分析结果为4P-据,探讨了中国英语学习者在1：2语表达过程中的英语单数第三人称代词（ETPSP）误用现象及其原因,结果表明：（1）中国大学生存在普遍的ETPSP误用现象,主要表现为主语he／she、宾语him／her和定语his／her三类间的误用,特别是主语he／she间的误用人数比例高达75％;（2）英语学习水平对ETPSP误用具有重要影响,且主要表现为低水平组对“she”产出的高错误率,主要原因是其对“he（she）”产出错误的认知实时监控能力缺乏。     

A study on purchasing behavior of teenagers in Taiwan: example of counterfeit goods

This study has established a relationship model encompassing such aspects as consumer values, consumer involvement, purchase behavior, and consumer satisfaction. Furthermore, taking counterfeit goods as an example, this study employs factor analysis, reliability analysis, and the structural equation model to verify the relationship between the research aspects. Another major discovery of this study was that teenagers' behavioral purchasing mentality is graphic, hyperlinked, and is geared toward useful situations and functional needs. When they consider their degree of need, they inevitably incorporate many emotional needs. However, their attitude toward counterfeit goods is rational, which is confirmed by the fact that Hypothesis 1 was not supported.     

Comparisons Across Depression Assessment Instruments in Adolescence and Young Adulthood: An Item Response Theory Study Using Two Linking Methods

Item response theory (IRT) methods allow for comparing the utility of instruments based on the range and precision of severity assessed by each instrument. As adolescents and young adults can display rapid increases in depressive symptoms, there is a crucial need to sensitively assess mild elevations of symptoms (as an index of initial risk) and moderate-severe symptoms (as an indicator of treatment disposition). We compare the information assessed by the Beck Depression Inventory (BDI) to the newly developed Patient Reported Outcome Measurement Information System – Depression measure (PROMIS-Depression), and the Center for Epidemiologic Studies – Depression (CES-D) scale. The present work is based on data from two fully independent samples of community adolescents and young adults. One sample completed the BDI and CES-D (n?=?1,482) and the second sample (n?=?673) completed the PROMIS-Depression measure and the CES-D. Using two different IRT-based linking methods, (1) equating based on common items and (2) concurrent calibration methods, analyses revealed that the PROMIS-Depression measure assessed information over the widest range of depressive severity with greatest measurement precision relative to the other instruments. This was true for both the 28-item and 8-item versions of the PROMIS-Depression measure. Findings suggest that the PROMIS-Depression measure assessed depression severity with greatest precision and over the widest severity range of the assessed instruments. However, future work is necessary to demonstrate that the PROMIS-Depression measure has reliable associations with external criteria and is sensitive to treatment response.     

Sinful flesh: Sexual objectification threatens women's moral self

The current investigation examined whether sexual objectification leads to perceived contamination in women victims, which, in turn, triggers sinful feelings. The results of three experiments provide converging support for these predictions. Female participants reported greater sinful feelings than their non-objectified counterparts, after receiving objectifying comments on their physical appearance from an alleged male partner (Experiment 1) or recalling a past experience of objectification (Experiments 2 and 3). Furthermore, perceived contamination mediated the effect of objectification on sinful feelings. We also found that perceived personal responsibility of being objectified moderated the above effects, such that the effects were only observed among participants who perceived themselves as highly responsible for objectification experience, but not among those who perceived low personal responsibility. These findings contribute to the literature by explaining why objectification elicits sinful feelings in female victims and who is more susceptible to this influence.     

Scientific Realism and the Meanings of Theoretical Terms

In contemporary philosophy of science, there are many interesting arguments for and against scientific realism with regard to the meaningfulness and truthfulness of theoretical statements. Some anti-realists hold that since many important concepts in scientific theories have no specific referents, the relevant theoretical statements are therefore either false or meaningless. In this essay, I join the debates concerning the plausibility of scientific realism by focusing on two intertwined issues： first, that of how we can we explicate the meaningfulness of theoretical statements, especially statements pertaining to unobservable objects, and second, that of the meaningfulness of theoretical statements for our acceptance of scientific realism.     

The Influence of Task Difficulty on Context Effect - Compromise and Attraction Effects

Research in psychology finds strong context effects in consumer behavior and help consumer make up their mind from choice set when none of each option better than the others in all aspects. Context effect signifies that when evaluating a focal option, individuals take into consideration characteristics of other comparative alternatives rather than only the features of that focal alternative, complicating the decision-making process. The compromise effect and attraction effect (known together as context effect) explain the underlying motivations that cause consumers to choose the middle option and introduce an inferior option to make the originally dominated option more preferable. But past research on this domain has predominantly used an easy-to-count choice scenario (refers to the ease of using individual’s math skill on comparative attributes in the choice task) which is not ideally existed in real world situation. In real world purchasing situations, most of the time consumers become confused by a variety of products presented with irregular pricing, packaging or attributes which are apparently difficult to compare by math skill. This paper aim to examine “When the level of difficulty changed while processing the comparative task on the context of a choice set, how does this influence the resultant occurrence of context effect?” Results from four experiments demonstrate that both compromise and attraction effects decreased when the choice task become more difficult.     

慢性应激性抑郁发生中大鼠眶额叶多巴胺D1受体对谷氨酸及其NMDA受体的调节

本文旨在探讨慢性应激性抑郁发生过程中眶额叶多巴胺D1受体对谷氨酸(glutamic acid, Glu)及其N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid, NMDA)受体的NR2B亚基的影响。实验通过建立慢性不可预见性温和应激(chronic unpredictable mild stress, CUMS)抑郁模型, 结合眶额叶微量注射多巴胺D1受体激动剂SKF38393和多巴胺D1受体拮抗剂SCH23390, 运用糖水偏爱测试、悬尾实验和敞箱实验等方法检测动物的行为表现, 采用高效液相色谱法(high-performance liquid chromatography, HPLC)和蛋白质免疫印迹法(Western blot, WB)来检测眶额叶内谷氨酸、多巴胺含量及NR2B和多巴胺D1受体的表达。结果显示, 与对照组相比, CUMS组大鼠表现出明显的抑郁样行为变化, 且眶额叶多巴胺含量降低, 其D1型受体表达降低, 谷氨酸含量升高, 其NMDA受体的NR2B亚基也明显上调; 注射SKF38393后可明显改善应激引起的抑郁样行为, 且眶额叶谷氨酸含量显著下降, NMDA受体的NR2B亚基表达也有所降低; 正常大鼠注射多巴胺D1受体拮抗剂SCH23390, 大鼠表现出和CUMS模型组相似的抑郁样行为, 且眶额叶谷氨酸含量升高, 其NMDA受体的NR2B亚基也明显上调。以上结果表明, 慢性不可预见性应激可能使眶额叶多巴胺释放减少, 从而使谷氨酸过量释放, NMDA受体过度激活, 导致抑郁发生。多巴胺抗抑郁作用是通过D1型受体抑制谷氨酸及其NMDA受体NR2B亚基表达来实现。     

不同情绪效价的DRM词表对错误记忆的影响

请49名在校大学生对自编的36个具有不同情绪效价的DRM词表进行评定,再以60名在校大学生为实验对象考察不同情绪效价的DRM词表对错误记忆的影响。结果发现,(1) 负性和中性DRM词表产生的错误记忆量显著高于正性DRM词表;(2) 被试在“记得/知道/猜测”判断上对负性和中性词表的关键诱饵倾向于“知道”,而对正性词表的关键诱饵更倾向于“记得”。结果表明,DRM词表本身所具有的情绪与人为诱发的情绪,对错误记忆的影响具有不同的性质和特点。     

How do children coordinate information about mental states with social norms?

We investigated how 3-7-year-olds weigh and coordinate information about specific mental states with social norms in the domain of contextually conventional rules. With increasing age, participants increasingly took into account an actor's mental state to predict that actor's behavior. In a criticism judgment task, 7-year-olds could assign criticism conditional on mental state, with response patterns similar to those of adults; 5-year-olds assigned criticism regardless of the actor's mental state. Three-year-olds tended not to assign criticism at all, irrespective of the actor's mental state. Results indicated that the ability to weigh and coordinate information about mental states with understanding of norms depends on age and on the particular type of judgment being made. To some extent, our results may also reflect the influence of culture and parenting.