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51.
Crowley Michael J. van Noordt Stefon J. R. Castagna Peter J. Vaca Federico E. Wu Jia Lejuez Carl W. Mayes Linda C. 《Journal of psychopathology and behavioral assessment》2022,44(2):297-311
Journal of Psychopathology and Behavioral Assessment - A large body of work documents the utility of behavioral risk tasks for making inferences about adolescent risk-taking proclivities and... 相似文献
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Post-acquisition release of glutamate and norepinephrine in the amygdala is involved in taste-aversion memory consolidation 总被引:1,自引:0,他引:1
Guzmán-Ramos K Osorio-Gómez D Moreno-Castilla P Bermúdez-Rattoni F 《Learning & memory (Cold Spring Harbor, N.Y.)》2012,19(6):231-238
Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation of this structure is necessary for the long-term storage of conditioned taste aversion (CTA). However, the specific neurotransmitters involved in such reactivation are not known. The aim of the present study was to investigate extracellular changes of glutamate, norepinephrine, and dopamine within the rat amygdala using in vivo microdialysis during the acquisition and 1-h post-acquisition of CTA paradigm. Microdialysis monitoring showed a significant norepinephrine increase related to novel taste exposure and a glutamate increase after gastric malaise induction by i.p. LiCl administration. Interestingly, we found a spontaneous concomitant increase of glutamate and norepinephrine, but not dopamine, 45 min after conditioning, suggesting the presence of aversive learning-dependent post-acquisition signals in the amygdala. These signals seem to be involved in CTA consolidation process, since post-trial blockade of N-methyl-D-aspartate or β-adrenergic receptors impaired long- but not short-term memory. These data suggest that CTA long-term storage involves post-acquisition release of glutamate and norepinephrine in the amygdala. 相似文献
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The posterior parietal cortex (PPC) is fundamental for sensorimotor transformations because it combines multiple sensory inputs and posture signals into different spatial reference frames that drive motor programming. Here, we present a computational model mimicking the sensorimotor transformations occurring in the PPC. A recurrent neural network with one layer of hidden neurons (restricted Boltzmann machine) learned a stochastic generative model of the sensory data without supervision. After the unsupervised learning phase, the activity of the hidden neurons was used to compute a motor program (a population code on a bidimensional map) through a simple linear projection and delta rule learning. The average motor error, calculated as the difference between the expected and the computed output, was less than 3°. Importantly, analyses of the hidden neurons revealed gain-modulated visual receptive fields, thereby showing that space coding for sensorimotor transformations similar to that observed in the PPC can emerge through unsupervised learning. These results suggest that gain modulation is an efficient coding strategy to integrate visual and postural information toward the generation of motor commands. 相似文献
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Osborne P. Wiggins John H. Barker Serge Martinez Marieke Vossen Claudio Maldonado Federico V. Grossi 《The American journal of bioethics : AJOB》2013,13(3):1-12
Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. 相似文献
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Most words in English have more than one syllable, yet the most influential computational models of reading aloud are restricted to processing monosyllabic words. Here, we present CDP++, a new version of the Connectionist Dual Process model (Perry, Ziegler, & Zorzi, 2007). CDP++ is able to simulate the reading aloud of mono- and disyllabic words and nonwords, and learns to assign stress in exactly the same way as it learns to associate graphemes with phonemes. CDP++ is able to simulate the monosyllabic benchmark effects its predecessor could, and therefore shows full backwards compatibility. CDP++ also accounts for a number of novel effects specific to disyllabic words, including the effects of stress regularity and syllable number. In terms of database performance, CDP++ accounts for over 49% of the reaction time variance on items selected from the English Lexicon Project, a very large database of several thousand of words. With its lexicon of over 32,000 words, CDP++ is therefore a notable example of the successful scaling-up of a connectionist model to a size that more realistically approximates the human lexical system. 相似文献
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Nicholas T. Davis Christopher M. Federico 《Journal for the scientific study of religion》2019,58(1):47-66
How do individuals psychologically organize their images of the divine? Most work on this topic is factor‐analytic in nature, finding that God images vary with respect to love, judgment, and engagement. However, few studies look at how individuals spontaneously combine these divine dimensions into composite images of God. To fill this gap, we subject data from the 2010 Baylor Religion Survey to latent class analysis and find evidence for five depictions of God: (1) a poorly defined, uninvolved deity; (2) a loving, nonjudgmental deity who is engaged with humanity; (3) a nullity or nonentity; (4) a loving deity who is neither judgmental nor engaged with humanity; and (5) a loving deity who is also both judgmental and engaged. We then present evidence that individuals holding these images vary in their denominational background, religious attitudes and behaviors, and general traits. Our findings suggest that individuals may impose not only a dimensional structure on images of the divine, but a categorical one as well. 相似文献
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The widely known discovery of mirror neurons in macaques shows that premotor and parietal cortical areas are not only involved in executing one's own movement, but are also active when observing the action of others. The goal of this essay is to critically evaluate the substance of functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies whose aim has been to reveal the presence of a parallel system in humans. An inspection of this literature suggests that there is relatively weak evidence for the existence of a circuit with 'mirror' properties in humans, such as that described in monkeys. 相似文献