Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory

In this work we probed the effects of post-trial infusions of the muscarinic receptor antagonist scopolamine on object recognition memory formation. Scopolamine was infused bilaterally immediately after the sample phase in the perirhinal cortex or dorsal hippocampus and animals were tested for short-term (90 min) or long-term (24 h) memory. Results showed that scopolamine impaired short-term memory when injected in either the perirhinal cortex or hippocampus. Nevertheless, scopolamine disrupted long-term memory when administrated in the perirhinal cortex but not when applied in the hippocampus. Long-term memory was unaffected when scopolamine was infused 160 min after the sample phase or 90 min before test phase. Our data indicate that short-term recognition memory requires muscarinic receptors signaling in both the perirhinal cortex and hippocampus, whereas long-term recognition memory depends on muscarinic receptors in the perirhinal cortex but not hippocampus. These results support a differential involvement of muscarinic activity in these two medial temporal lobe structures in the formation of recognition memory.     

The ontogenetic ritualization of bonobo gestures

Great apes communicate with gestures in flexible ways. Based on several lines of evidence, Tomasello and colleagues have posited that many of these gestures are learned via ontogenetic ritualization—a process of mutual anticipation in which particular social behaviors come to function as intentional communicative signals. Recently, Byrne and colleagues have argued that all great ape gestures are basically innate. In the current study, for the first time, we attempted to observe the process of ontogenetic ritualization as it unfolds over time. We focused on one communicative function between bonobo mothers and infants: initiation of “carries” for joint travel. We observed 1,173 carries in ten mother–infant dyads. These were initiated by nine different gesture types, with mothers and infants using many different gestures in ways that reflected their different roles in the carry interaction. There was also a fair amount of variability among the different dyads, including one idiosyncratic gesture used by one infant. This gestural variation could not be attributed to sampling effects alone. These findings suggest that ontogenetic ritualization plays an important role in the origin of at least some great ape gestures.     

Where Am I? A new case of developmental topographical disorientation

Recently, developmental topographical disorientation (DTD) was described (Bianchini et al., 2010, J Clin Exp Neuropsychol, 20, 807–27; Iaria & Barton, 2010, Exp Brain Res, 206, 189–96; Iaria, Bogod, Fox, & Barton, 2009, Neuropsychologia, 47, 30–40) as a navigational deficit in the absence of neurological or psychiatric disorders. Here, we reported the case of a healthy subject who presented this disorder. Dr. WAI was a 29‐year‐old right‐handed man with normal development and no clinical history of neurological or psychiatric diseases who was affected by a very pervasive topographical orientation and navigational disorder. A neuroradiological exam confirmed the absence of structural and anatomical alterations of the brain. Dr. WAI was submitted to an extensive neuropsychological examination and to a battery of tests specifically developed to assess developmental topographical disorder. Using this battery, we analysed Dr. WAI's acquisition of navigational information and re‐orientation processes. He showed severe DTD accompanied by deficits of different cognitive processes directly or indirectly involved in navigational skills. Dr. WAI showed a deficit in developing cognitive maps, already found in previous cases, plus difficulties in evaluating distances and computing metric environmental features. He represents a further confirmation of the existence of DTD suggesting dissociations within the disorder related to the level of development of the ability to build cognitive maps and the association of different imagery deficits. Dr. WAI can help in shedding some light on the mechanisms underlying lack of development of navigational skills.     

Identification of risk factors for suffering fear of hypoglycemia in type 1 Diabetes Mellitus patients

Hypoglycemia is one of the main burdens for type I Diabetes Mellitus (DM I) patients. The consequences of hypoglycemia can be quite unpleasant due to the variety of disagreeable physical and psychological symptoms it triggers. The patient's previous experience with hypoglycemia episodes will condition his psychological reaction to future episodes, promoting behavioral modifications that associate with poor glycemic control and worse prognosis, and even with developing psychological disorders, leading to fear of hypoglycemia (FH). To be able to provide tailored prevention and treatment of patients with FH it is necessary to identify the risk factors in DM I patients. We developed and validated the FH‐15 scale, a novel instrument to assess FH, which showed good concurrent and predictive validity in DM I patients. In this work we aim to identify the risk factors for suffering FH by detecting DM I patients with FH using the FH‐15 scale and then analyzing the association of clinical and sociodemographic variables. We found that age, needing help to resolve an episode of hypoglycemia, and a perceived lack of social support are risk factors for suffering FH.     

Gender Differences in the Perception of Honour Killing in Individualist Versus Collectivistic Cultures: Comparison Between Italy and Turkey

Gender differences in the perception of honour killing were investigated in two countries, both traditionally considered honour cultures but with differing degrees of individualism and collectivism: Italy and Turkey. Ninety-six Turkish undergraduate students attending Istanbul University (40 % males, mean age?=?21.2 years) and 68 Italian undergraduate students attending Turin University (34 % males, mean age?=?24.6 years) filled in a questionnaire which assessed the perception of three honour killing scenarios (scenario 1: alleged adultery, scenario 2: adultery, scenario 3: adultery in flagrante delicto). The questionnaire measured the attribution of assailant and victim responsibility, the proposed punishment for the assailant, and the evaluation of the incidents as crimes. Results showed that regardless gender Turkish participants attributed more responsibility to the victim and less responsibility to the assailant, and proposed less severe punishments than the Italian participants. Moreover, Turkish men attributed less responsibility to the assailant and proposed less severe punishments than Turkish women. Finally, there was an interaction of gender by culture by scenario: Turkish women attributed less responsibility to the victim in the case of alleged adultery, compared to their male counterparts. These results are discussed in terms of the complex interaction between gender roles and the individualist versus collectivist social organization of Italy and Turkey, and the profound social changes that both countries have undergone in recent decades.     

A defense of surgical procedures regulation

Theoretical Medicine and Bioethics - Since the advent of drug regulation in 1962, regulatory agencies have been in the practice of using strict standards to test the safety and efficacy of medical...     

Toward a further understanding of assent

Arranging assent opportunities is an increasingly common strategy for involving clients in therapeutic decisions within behavior analysis. Recent behavior-analytic articles have helped create a basic behavioral definition and conceptualization of assent, but much more guidance is needed for practitioners and researchers interested in embedding assent into their practices. The purpose of this article is to advance the conceptualization and understanding of assent and assent practices by refining previous definitions and conceptualizations of assent and providing six essential considerations for embedding assent into practice. The six considerations consist of determining the applicability and feasibility of assent, assessing assent-related skills, arranging assent procedures and teaching assent-related skills, arranging fair choices, selecting opportunities to assess assent, and informally assessing assent. Following the discussion of the considerations for assent practices, we issue a call for specific topics of research on assent.