Incidence of depression related to isotretinoin treatment in 100 acne vulgaris patients

The incidence of depression in acne patients using isotretinoin was assessed in 100 patients with moderate and nodulocystic acne. All patients received 0.75-1.00 mg/kg/day of isotretinoin for 20-28 weeks after acne was assessed. All patients' acne lesions were improved at the end of the treatment period. Psychological state was evaluated at baseline, at Month 3, and Month 6 by a psychiatrist using a Turkish version of the Hamilton Depression Rating Scale. Only one patient's score increased to the clinical level of depression at Month 3 of treatment and declined to subclinical levels at Month 6. Although Hamilton scores increased at Month 3 over baseline scores, except for one patient, others' scores remained below the subclinical level for depression. At the end of Month 6, the mean score decreased below that at Month 3. These changes in means might be related to the onset of clinical effect of isotretinoin.     

Learned helplessness,therapy, and personality traits: an experimental study

The authors investigated 3 aspects of the learned helplessness (LH) phenomenon: the induction of helplessness in humans by a new instrumental task, the effects of a therapy technique that relies on direct retroactive reevaluation of the helplessness experience, and the role of personality characteristics in both helplessness induction and therapy. The sample consisted of 92 Turkish Bo?azi?i University undergraduates, 42 men and 50 women. The authors exposed 2 experimental groups to an LH induction by presenting them with an unsolvable maze task; 1 group received therapy afterward, and the other group did not. There were also 2 control groups: a group that received only a solvable version of the maze and another group that received no treatment. Before the experimental procedure, all participants completed the Turkish version of the NEO-Five Factor Inventory (FFI). The authors evaluated picture-rating and anagram-solving performances to differentiate the cognitive and emotional deficits of LH. Results of the factorial analyses of variance and the Wilcoxon signed ranks test supported the success of both the helplessness induction and the therapy technique. Although no significant gender differences were found in the effects of the helplessness-induction and therapy procedures, correlation analyses revealed that individual differences, particularly in the interaction between gender and personality characteristics, can have an important impact on LH and on the capacity to benefit from therapy.     

刍议儒释道之"和"

本文探讨传统文化中儒释道对"和"的论述,认为"和"是中国历史文化的特征,古代先哲的生命信仰和思维基础.     

A population-based study of body image concerns among urban Chinese adults

Using a nationally representative Chinese urban sample of 930 women and 893 men aged 20–45 who were married or had a steady sexual partner, this study examines the prevalence, risk factors and sequelae of body image concerns. Women's weight loss desires begin at modest BMI levels and are more pronounced among youth, among people of urban origin, and among the educated. Women also have stronger body image concerns if they are single, living in coastal areas, taller or larger than their partner, or if their relationship with their partner is poor. Moreover, women who perceive themselves as unattractive and who want to lose weight report more psychological distress. These findings suggest that China has joined the worldwide diffusion of the thin ideal, with negative consequences for women.     

The role of personality factors in predicting the reported physical health symptoms of Turkish college students

This study investigates the role of optimism, health control beliefs, perceived health competence, and medical help-seeking variables in predicting the frequency of reported physical symptoms. A total of 345 college students (207 male and 138 female) were presented with the Life Orientation Test, Multidimensional Health Locus of Control, Perceived Health Competence Scale, and Physical Symptom Checklist. Separate stepwise multiple regression analyses were applied to the data obtained from males, females, and the total group of students. Results showed that optimism, medical help seeking, chance health locus of control, and internal health locus of control predicted the reported physical symptom scores of the total sample. Also revealed were the different patterns for males and females. While optimism and internal health locus of control best predicted physical health for males, optimism and chance health locus of control best predicted the physical health symptoms of females.     

Effects of bilingual and monolingual presentations and time on concept- and language-matching tasks

Balanced Turkish-English bilingual participants viewed word pairs, presented both monolingually (English-English or Turkish-Turkish) or bilingually (English-Turkish or Turkish-English) and both for short and long durations. They made decisions on whether the simultaneously presented words in a pair were in the same language or not, or whether they denoted the same concept or not. In the short presentation condition, we found no evidence for subliminal processing. In cases in which both words were consciously identified, participants were more accurate, although not faster in the long than in the short presentation condition for both language and concept decisions. In the long presentation condition, language decisions were more accurate than concept decisions, although not faster. In addition, language decisions were not affected by whether the words were synonyms (concept identity), and concept decisions were not affected by whether the presentation was monolingual or bilingual (language identity), although in the monolingual conditions, "same" decisions were faster but not more accurate, and in the bilingual conditions a speed-accuracy trade-off was observed in that "same" decisions were faster but "different" decisions were more accurate.     

Use of parafoveally visible characters during the reading of Chinese sentences

Chinese readers' use of parafoveal character previews was examined. In Experiment 1, the preview of target characters consisted of targets or of graphemically similar, homophonic, or dissimilar characters. Each preview was replaced with the corresponding target when the eyes reached the target location. Oculomotor measures revealed preview benefits for targets, for graphemically similar characters, and for homophonic characters. Experiment 2 showed that parafoveal preview of graphemically similar characters yielded benefits primarily when they shared the phonetic radical with their targets. The phonological relationship between previewed radicals and subsequently viewed targets was ineffective. Chinese character processing thus involves the initial use of orthographic information from the phonetic radical and the activation of the character's phonological form.     

Prospects for prenatal gene therapy in disorders causing mental retardation

Advances in understanding the genetics and pathogenesis of disease and in prenatal diagnosis have lead to an exploration of ways to intervene earlier and earlier in the disease process. The possibility of prenatal gene therapy for severe genetic and developmental disorders has sparked new research and debate as to its feasibility, reliability, and ethics as a therapeutic option. Recent animal studies have demonstrated the feasibility of introducing a vector into the developing fetus. The optimal timing and best mode of delivery, however, have yet to be defined. Whether or not this research should be pursued also has been the subject of recent bioethical debates. There is additional concern with the possibility of in utero gene transfer inducing mutagenesis and subsequent tumor formation. This review will provide a summary of the current state of knowledge in the field of prenatal gene therapy and possible directions for the future research.     

High-resolution electron microscopy observations of microplastic fracture in SiC under ball milling at room temperature

Nanometre-sized kinks and cracks formed in 6H SiC under ball milling (BM) at room temperature have been observed and characterized on the atomic scale using high-resolution electron microscopy (HREM). Observations of the kinks show that numerous positive and negative partials are aligned at either of the kink boundaries, and the stacking sequences in the kink band are considerably different from those in the other areas. It was also observed that the (0001) lattice planes in the kink band are kinked, indicating that microplasticity occurs in the normally brittle material SiC under BM even at room temperature. HREM observations of cracks show that cracks previously observed by transmision electron microscopy are not completely open but are at the initiation stage of fracture. Inside a crack, one residual kink region can be clearly observed, which indicates a correlation between kink and crack, that is a crack evolves from a kink.