Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on hippocampus, immunohistochemical studies in aged THY-Tau22 mice revealed prominent hyper- and abnormal phosphorylation of tau in CA1 region, and an increase in glial fibrillary acidic protein (GFAP) in hippocampus, but without signs of neuronal loss. These mice displayed spatial, social, and contextual learning and memory defects that could not be reduced to subtle neuromotor disability. The behavioral defects coincided with changes in hippocampal synaptic functioning and plasticity as measured in paired-pulse and novel long-term depression protocols. These results indicate that hippocampal tauopathy without neuronal cell loss can impair neural and behavioral plasticity, and further show that transgenic mice, such as the THY-Tau22 strain, might be useful for preclinical research on tauopathy pathogenesis and possible treatment.     

Comparative Study of Chinese and American Media Reports on the COVID-19 and Expressions of Social Responsibility: A Critical Discourse Analysis

Journal of Psycholinguistic Research - Critical discourse analysis aims to explore the dialectical relationship between discourse and ideology. Based on psycholinguistic research, this paper...     

Are Religious People More Prosocial? A Quasi-Experimental Study with Madrasah Pupils in a Rural Community in India

Using quasi-experimental data, this article examines the relationship between religiosity and prosocial behavior. In contrast to previous studies that identify religious people by how often they attend religious services or by their self-reported religiosity, this study compares the behavior of highly devout students who are preparing to enter the clergy to the behavior of other students in a public goods game and in the dictator game. The results show that religious students were significantly more cooperative in the public goods game and significantly more generous in the dictator game than other students.     

THE LASH IS MIGHTIER THAN THE SWORD1: Torture and Citizenry in Medieval Muslim Jurisprudence

Medieval Muslim scholars unequivocally prohibited the torture of prisoners of war out of a concern for maintaining theoretical constructs about the boundaries of the Muslim and non‐Muslim communities. Muslim scholars worried that the torturing prisoners of war would compromise values and ideals predicated on such constructs, and that the demands of citizenship trumped any benefit to the Muslim community that might accrue from torture.     

Introducing Identity

The best-known syntactic account of the logical constants is inferentialism . Following Wittgenstein’s thought that meaning is use, inferentialists argue that meanings of expressions are given by introduction and elimination rules. This is especially plausible for the logical constants, where standard presentations divide inference rules in just this way. But not just any rules will do, as we’ve learnt from Prior’s famous example of tonk, and the usual extra constraint is harmony. Where does this leave identity? It’s usually taken as a logical constant but it doesn’t seem harmonious: standardly, the introduction rule (reflexivity) only concerns a subset of the formulas canvassed by the elimination rule (Leibniz’s law). In response, Read [5, 8] and Klev [3] amend the standard approach. We argue that both attempts fail, in part because of a misconception regarding inferentialism and identity that we aim to identify and clear up.

     

The Effect of Non-conscious Perception of Frequent Stimuli on Credibility Judgement

The aim of the work presented here is to investigate the effects of mere-exposure to familiar and unfamiliar stimuli (as primes) on credibility judgement about sentences unrelated to the primes. These target sentences are presented just after the prime. In all, 124 students participated in 3 priming experiments. The nature of the primes (both infraliminary and supraliminary) is different in each experiment: we used public vs. unknown faces, exposed vs. unexposed faces, and objects vs. nonobjects. Primes were presented for 50msec or 400msec. After the presentation of each prime, subjects had to judge the credibility of an assertion; its ambiguity has previously been tested with 100 subjects. The results show that assertions which follow familiar primes (public faces, exposed faces, or objects) are granted more credibility that those which follow unfamiliar primes (unknown faces or nonobjects). This effect is observed especially when presentation time is 50msec.     

Bilingualism and the perception of professional concepts

A selected set of professional concepts was subjected to analysis through two separate multidimensional scaling techniques, the INDSCAL and TORSCA models, to evaluate the intergroup perceptual differences of four experimental groups, made up of unilingual French, unilingual English and bilingual students. The linguistic relativism thesis provided the research hypotheses on the relationship between language access and usage and concept perception. The multidimensional scaling techniques were applied to the matrix of subjects' similarity judgments on pairs of concepts, thus enabling the identification of three dimensions. The dimensions were labelled as conjunctive, relational and disjunctive, and were assumed to be related to the criteria employed by the subjects in their similarity rankings. An analysis of variance of the individual saliences on each dimension provided evidence of linguistic relativism for both the relational and disjunctive dimensions. These findings support the contention that unilingual speakers of separate languages differ from each other and from bilingual speakers in their perception of professional concepts.     

A new approach to explain aggression

Two separate experiments are reported. They show the methodological difficulties and subsequent conceptual complications in Berkowitz's modified frustration-aggression theory and Zillman's theory of aggression. There was a marginally significant difference in the verbal measure of aggression favouring subjects aroused by frustration over subjects aroused by exercise, but not on the behavioral measure of aggression. Exp. II was conducted to test an alternative hypothesis, deduced from Fraisse's theory of emotion, which states that subjects respond more aggressively when confronted with unexpected than with expected annoyance. All six measures of aggression confirmed the hypothesis. The results of these two experiments indicate conceptual and methodological difficulties inherent in Berkowitz's modified frustration-aggression theory and Zillman's theory of aggression; they also suggest that Fraisse's theory of emotion presents a better model of aggression.     

Catching up with wonderful women: The women‐are‐wonderful effect is smaller in more gender egalitarian societies

Inequalities between men and women are common and well‐documented. Objective indexes show that men are better positioned than women in societal hierarchies—there is no single country in the world without a gender gap. In contrast, researchers have found that the women‐are‐wonderful effect—that women are evaluated more positively than men overall—is also common. Cross‐cultural studies on gender equality reveal that the more gender egalitarian the society is, the less prevalent explicit gender stereotypes are. Yet, because self‐reported gender stereotypes may differ from implicit attitudes towards each gender, we reanalysed data collected across 44 cultures, and (a) confirmed that societal gender egalitarianism reduces the women‐are‐wonderful effect when it is measured more implicitly (i.e. rating the personality of men and women presented in images) and (b) documented that the social perception of men benefits more from gender egalitarianism than that of women.     

Emotional capture by fearful expressions varies with psychopathic traits

Task-irrelevant emotional expressions are known to capture attention, with the extent of “emotional capture” varying with psychopathic traits in antisocial samples. We investigated whether this variation extends throughout the continuum of psychopathic traits (and co-occurring trait anxiety) in a community sample. Participants (N?=?85) searched for a target face among facial distractors. As predicted, angry and fearful faces interfered with search, indicated by slower reaction times relative to neutral faces. When fear appeared as either target or distractor, diminished emotional capture was seen with increasing affective-interpersonal psychopathic traits. However, moderation analyses revealed that this was only when lifestyle-antisocial psychopathic traits were low, consistent with evidence suggesting that these two facets of psychopathic traits display opposing relationships with emotional reactivity. Anxiety did not show the predicted relationships with emotional capture effects. Findings show that normative variation in high-level individual differences in psychopathic traits influence automatic bias to emotional stimuli.