Systemic and intrahippocampal administrations of the glucocorticoid receptor antagonist RU38486 impairs fear memory reconsolidation in rats

Reconsolidation is the process by which previously consolidated memories are stabilized after retrieval. Several lines of evidence indicate that glucocorticoids modulate distinct phases of learning and memory. These effects are considered to be mediated by mineralocorticoid receptors and glucocorticoid receptors (GRs), which display a high concentration and distinct distribution in the hippocampus. The role of glucocorticoid system in fear memory reconsolidation is the subject of some controversy. Moreover, we found no studies that assessed the role of hippocampal GRs in fear memory reconsolidation. Here, we investigated the effect of GR blockade on fear memory reconsolidation in rats. Rats were trained and tested in an inhibitory avoidance task. Intrahippocampal or systemic administration of the GR antagonist RU38486 immediately following memory reactivation produced a deficit in post-retrieval long-term memory that persisted over test sessions, and memory did not re-emerge following a footshock reminder. These results indicate that hippocampal GRs are required for reconsolidation of fear-based memory.     

A computational analysis of mental image generation: evidence from functional dissociations in split-brain patients

Recent efforts to build computer simulation models of mental imagery have suggested that imagery is not a unitary phenomenon. Rather, such efforts have led to a modular analysis of the image-generation process, with separate modules that can activate visual memories, inspect parts of imaged patterns, and arrange separate parts into a composite image. This idea was supported by the finding of functional dissociations between the kinds of imagery tasks that could be performed in the left and right cerebral hemispheres of two patients who had previously undergone surgical transection of their corpus callosa. The left hemisphere in both subjects could inspect imaged patterns and could generate single and multipart images. In contrast, although the right hemisphere could inspect imaged patterns and could generate images of overall shape, it had difficulty in generating multipart images. The results suggest a deficit in the module that arranges parts into a composite. The observed pattern of deficits and abilities implied that this module is not used in language, visual perception, or drawing. Furthermore, the results suggest that the basis for this deficit is not a difficulty in simply remembering visual details or engaging in sequential processing.     

Trust,Distrust, and Security: An Untrustworthy Immigrant in a Trusting Community

In security studies, there is an unquestioned assumption of a linear link between trust and security. However, such an assumption neglects complex identity dynamics that can be involved in trust‐building discourses for engendering security. There needs to be greater examination into what is meant by trust, and upon what, and whom, and how the politics of identity works in social trust building and how states can influence this process. This article contributes to the literature on trust, security, and identity in International Relations (IR) by making a case for a conceptual focus on the formation of particularized distrust towards “the other” as a corollary to trust and security of “the self.” It is argued that in the construction of a political community where security is associated with trust, particularized distrust can also be promoted through institutional discourses—strengthening the “trusting we” by constructing “the other” who can challenge social trust and feelings of security associated with it. The argument is illustrated through critically examining a state‐level narrative in Norway in relation to “the other,” that is, the immigrant. Through this illustrative example, mutual constitutiveness of trust and distrust in a self/other discursive construction will be shown.     

Studying Emotions in Security and Diplomacy: Where We Are Now and Challenges Ahead

The core objective of this special issue has been to shed light on emotions as (1) frames that shape interpersonal diplomatic relations, (2) as key tools that are used as part of the statecraft's toolbox, and (3) as formative/productive dynamics with real effects on human beings—that, in turn, often construct and maintain conflicts. It is therefore pertinent that we interrogate the political psychology of individual, collective, mass, and communal emotions and how these are often (mis)used in diplomacy and security narratives to legitimize politicians' decisions and practices. This concluding article provides a state of the art account of the study of emotions in International Relations (IR), sums up the main findings from all special issue contributions and constructively explores potential challenges ahead for the study of emotions in IR, especially in security and diplomacy studies. It concludes with an appeal for the development of a multiperspective approach—that is, one that combines social sciences, natural sciences, and humanities—for a nuanced study of the role of emotional work in state, diplomatic as well as security narratives and practices. This approach will in turn require methodological pluralism in how we go about, as reflexive researchers, our emotional research.     

Influence of affective distractors on working memory capacity in relation to symptoms of posttraumatic stress disorder

Symptoms evoked in individuals with posttraumatic stress disorder (PTSD) when processing trauma‐relevant material arguably impair higher order cognitive functions. An example is working memory capacity (WMC), which has been shown to be disrupted by affective distractors. However, it is unknown whether this association varies across different types of PTSD symptoms. This study explored the association between WMC performed in affective (relative to neutral) contexts in relation to different symptoms of PTSD (avoidance, re‐experiencing, hyperarousal). Motor vehicle accident survivors with PTSD and without PTSD completed a delayed‐match‐to‐sample task including trauma‐related, neutral, and scrambled distractors in the interval between the presentation of the memoranda and the recognition target. The results showed that there was support for an indirect pathway between PTSD diagnosis and WMC performed in affective (versus neutral) contexts through re‐experiencing and avoidance symptoms. The findings suggest that avoidance symptoms in particular may benefit from interventions directed at improving WMC.     

Embracing mental illness: do education and contact make any difference in help-seeking intention among Pakistani students?

Those suffering from mental illness usually fall victim to stigmatization and the resulting discrimination. This study aims at finding out whether students differ in their attitudes based on the courses studied and previous contact with mentally ill. Using purposive sampling technique, 236 students from seven departments of University of Karachi were selected for this study. They were divided into three groups based on their educational background i.e. “psychology group”, “allied group” and “other group”. Community Attitude towards Mental Illness (CAMI) Scale along with a demographics sheet were administered to the participants. Using SPSS version 23, one-way ANOVA was carried out between educational groups and responses of CAMI sub-scales. Results indicated that in comparison to the other two groups, attitudes of psychology students were lower on authoritarianism, social restrictiveness subscales and higher on community mental health ideology subscale. Results are discussed in detail.     

Temperament-Character Profile and Psychopathologies in Patients with Alopecia Areata

The aim of this study is to investigate psychopathologies and the temperament-character profile of Alopecia Areata patients and to compare them with healthy controls. Patients and controls who presented at a dermatology clinic were selected by convenience sampling to respond to Temperament and Character Inventory (TCI), SCL-90-R, and a checklist about the demographic data and their dermatologic and psychiatric history. Patients reported higher harm avoidance and reward dependence than controls (Cohen's d = .93 and = .94). A significant correlation between Harm Avoidance (r = ?0.33, p = .02) and Reward Dependence (r = ?0.28, p = 0.05) with sex was found (females scored higher). Lifetime history of AA relapse was significantly associated with higher psychiatric symptoms; the effect sizes were large for Obsessive-Compulsive (d = .81) and Paranoia Ideation (d = .89). The higher psychological symptoms in AA patients with the history of relapses in this study have a practical message for clinicians.     

The Association Between Muslim Religiosity and Young Adult College Students’ Depression,Anxiety, and Stress

Depression, anxiety, and stress are among major psychological disorders being predominant in present day. This study proposed to analyze the role of Muslim religiosity in male students showing these mental indications. A sample including 723 Pakistani young adults enrolled at college level was randomly chosen. Muslim Religiosity Measurement Scale and Depression, Anxiety and Stress Scale were utilized to gather information. Discoveries uncover an inverse relationship between conduct and affiliation with the symptoms of mental disorders, anxiety and stress among the respondents. Results bolster the incorporation of religious dimensions in psychological wellness and mental well-being thought of young adults in Pakistan.