Mechanism of isoflavone aglycone's effect on cognitive performance of senescence-accelerated mice

This study investigated the effect of isoflavone aglycone (IA) on the learning and memory performance of senescence-accelerated mice, and explored its neural protective mechanism. Results showed that SAM-P/8 senescence-accelerated mice treated with IA performed significantly better in the Y-maze cognitive test than the no treatment control (P<0.05). The cortex AchE activity, serum SOD and GSH-Px activities were notably higher (P<0.05). MDA concentration and the β-secretase activity in the hippocampal tissue were both lower (P<0.05). Additionally, the number of hippocampal neurons was increased and cell morphology was significantly improved. Data suggested that IA could indirectly increase concentration of the cholinergic neural transmitter Ach through regulation of AchE, therefore improving the central cholinergic function and enhancing the learning and memory ability. By reducing the β-secretase activity, IA could decrease the formation and deposition of insoluble Adebris, relieve the resulted toxicity and damage to neurons, and thereby effectively protect the nervous system.     

Correction to: Organizational Benefits of Onboarding Contingent Workers: an Anchoring Model Approach

Journal of Business and Psychology -     

Is It OK If Mommy Dates? The Influence of Mother’s Post-Divorce Dating Transitions for Children’s Behaviors

Journal of Child and Family Studies - Despite many mothers’ interest in establishing romantic relationships following divorce, some worry about the impacts of dating transitions, such as...     

Household Chaos and Caregivers’ and Young Children’s Mental Health during the COVID-19 Pandemic: A Mediation Model

Journal of Child and Family Studies - Based on 764 households with young children in Wuhan, China, where the COVID-19 pandemic started, this study investigated how household chaos during the...     

Goal complexes: Integrating achievement goals as standards and self-attributed motives as reasons underlying goal pursuit

Goal complexes, which are formed by pairing standards of competence strivings with their underlying reasons, are essential to an understanding of achievement goal regulation. This paper examines goal complexes that cross other-approach and other-avoidance goals with the approach-avoidance dimensions of Big Three motives as underlying reasons. 220 undergraduates participated in Study 1 which developed and validated the Self-Attributed Motive Scale to measure hope of success, fear of failure, hope of affiliation, fear of rejection, hope of power, and fear of loss of power. Additionally, 235 undergraduates participated in Study 2 where goal complexes were created by crossing the motive items developed in Study 1 with other-approach and other-avoidance goals. The predictive utility of the resultant goal complexes was examined in relation to positive well-being (positive learning-related emotions and engagement), negative well-being (negative learning-related emotions and burnout), and academic buoyancy. The contributions of the studies to the self-attributed motive and goal complex literatures are discussed.

     

The Shared Values of Humanity and Its Philosophical Implications: From the Perspective of Civilization

The concept of the shared values of humanity, embodying the spirit of putting people first and solving real-life problems, is of great significance for constructing a new global order and building a human community with a shared future. The shared values of humanity respect the differences in understanding and realization paths of different civilizations, and seek common grounds with an inclusive and open attitude. The core socialist values are an embodiment and an extension of the shared values of humanity. The fine traditional Chinese culture has also laid a profound cultural basis for the pursuit of the shared values of humanity, enabling us to make up a better scheme for building a human community with a shared future from the perspective of civilization.     

Intentionality and partial belief

Suppose we wish to provide a naturalistic account of intentionality. Like several other philosophers, we focus on the intentionality of belief, hoping that we may later supplement our account to accommodate other intentional states like desires and fears. Now suppose that we also take partial beliefs or credences seriously. In cashing out our favoured theory of intentionality, we may for the sake of simplicity talk as if belief is merely binary or all-or-nothing. But we should be able to supplement or modify our account to accommodate credences. I shall argue, however, that it is difficult to do so with respect to certain causal or teleological theories of intentionality-in particular, those advanced by the likes of Stalnaker (Inquiry, 1984) and Millikan (J Philos 86:281–297, 1989). I shall first show that such theories are tailor-made to account for the intentionality of binary beliefs. Then I shall argue that it is hard to extend or supplement such theories to accommodate credences. Finally, I shall offer some natural ways of modifying the theories that involve an appeal to objective probabilities. But unfortunately, such modifications face problems.     

微流控分析芯片在循环肿瘤细胞检测中的运用

随着人们对于肿瘤性疾病的发生、发展、转移机制的进一步探索,循环肿瘤细胞（CTCs）逐渐进入人们视野,其应用价值日益体现,可用于肿瘤性疾病的早期诊断及治疗效果的监测,尤其是对于早期肿瘤的诊断具有独特优势。其富集技术及检测方法也在发生着日新月异的变化。近年来,微流控分析芯片技术运用于 CTCs 的富集及检测,具有高丰度、高富集度、高活性及不需要对样本进行预处理等优点使得人们聚焦于此技术,本文对微流控分析芯片在 CTCs 检测中的运用做简要综述。     

Neural correlates of inefficient filtering of emotionally neutral distractors from working memory in trait anxiety

Research has indicated that highly trait-anxious (HTA) individuals exhibit a specific deficit in filtering threat-related distractors from visual–spatial working memory (WM). Prior demonstrations of impaired inhibition control in HTA individuals have mainly focused on tasks that required the inhibition of prepotent response tendencies. Studies on the suppression of emotionally neutral distractors from WM in trait anxiety have also been minimal. In this article, we present a study on the manifestation of general inefficient filtering of neutral distractors during visual–spatial WM maintenance stages in HTA individuals. Female participants performed a visual–spatial WM task while event-related potentials were recorded. They were made to remember the orientations of red rectangles within half of the screen and to ignore all salient green rectangles. As predicted, no significant main effect of group and no interaction between group and condition were found in the N2pc component, suggesting that group differences did not manifest in the initial process of object individuation. During the subsequent WM maintenance phase, HTA individuals were highly inefficient at filtering the irrelevant items from WM, as reflected not only by parallel late contralateral delay activity (CDA; 450 to 900 ms) amplitudes for the distractor condition and the four red items, but also by a smaller filtering efficiency score in the HTA group than in the low-trait-anxiety group. Extending previous studies, our findings verify a general filtering impairment in HTA individuals for task-irrelevant salient distractors during a WM maintenance phase.