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Hartry Field has argued that Alfred Tarski desired to reduce all semantic concepts to concepts acceptable to physicalism and that Tarski failed to do this. In the two succeeding decades, Field has been charged with being too lenient with Tarski; but it has been almost universally accepted that an objection at least as strong as Field's is telling against Tarski's theory. Close examination of the relevant literature, most of it printed in this journal in the 1930s, reveals that Field's conception of physicalism is anachronistic. Tarski did succeed in furthering the sort of physicalist program he had in mind.  相似文献   
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The Specific Role of cGMP in Hippocampal LTP   总被引:5,自引:2,他引:3       下载免费PDF全文
Previous results have suggested that cGMP is involved in hippocampal long-term potentiation (LTP), perhaps as the presynaptic effector of a retrograde messenger. However, other studies have failed to replicate some of those results, making the role of cGMP uncertain. We therefore reexamined this question and identified several variables that can affect the contribution of cGMP. First, brief perfusion with 8-Br–cGMP before weak tetanic stimulation produced long-lasting potentiation in the CA1 region of hippocampal slices, but more prolonged perfusion with 8-Br–cGMP before the tetanus did not produce long-lasting potentiation. Second, the activity-dependent long-lasting potentiation by cGMP analogs was reduced when NMDA receptors were completely blocked, indicating that NMDA receptor activation contributes to, but is not required for, the potentiation. The amount of reduction of the potentiation differed with different protocols, and in some cases could be complete. Third, LTP produced by strong tetanic stimulation in the stratum radiatum of CA1 (which expresses eNOS) was blocked by inhibitors of soluble guanylyl cyclase or cGMP-dependent protein kinase, but LTP in the stratum oriens (which does not express eNOS) was not. The results of these experiments should help to explain some of the discrepant findings from previous studies, and, in addition, may provide insights into the mechanisms and functional role of the cGMP-dependent component of LTP.  相似文献   
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The replication of intergenerational patterns is considered here within the supervisor-family therapist-and family system, and the proposal of integrating a family of origin approach into the training of supervisors is presented. To become aware of the relation of one's own family of origin issues and their potential impact within the supervision and treatment can effectively improve intervention approaches, benefitting the supervisor, the therapist and the family in treatment. Being considerate of the training needs and levels of supervisors is an important component when integrating family of origin work into the training.  相似文献   
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The development of an emphasis on applied behavior analysis in the Department of Psychology at West Virginia University is traced. The emphasis began primarily in the early 1970s, under the leadership of Roger Maley and Jon Krapfl, and has continued to expand and evolve with the participation of numerous behavior analysts and behavior therapists, both inside and outside the department. The development has been facilitated by several factors: establishment of a strong behavioral emphasis in the three Clinical graduate programs; change of the graduate program in Experimental Psychology to a program in basic Behavior Analysis; development of nonclinical applied behavior analysis within the Behavior Analysis program; establishment of a joint graduate program with Educational Psychology; establishment of a Community/Systems graduate program; and organization of numerous conferences. Several factors are described that seem to assure a stable role for behavior analysis in the department: a stable and supportive "culture" within the department; American Psychological Association accreditation of the clinical training; a good reputation both within the university and in psychology; and a broader community of behavior analysts and behavior therapists.  相似文献   
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The fourth wave of the National Congregations Study (NCS-IV) was conducted in 2018–2019 with a nationally representative sample of congregations from across the religious spectrum. The NCS-IV included a fresh cross-section of congregations generated in conjunction with the 2018 General Social Survey and a panel of congregations that participated in the third NCS wave. Data were collected via a 65-minute interview with one key informant from 1,262 congregations. The cooperation rate was 74 percent; the conservatively calculated response rate was 69 percent. Information was gathered about multiple aspects of congregations’ social composition, structure, activities, leadership, and programming. Approximately two-thirds of the NCS-IV questionnaire replicates items from previous NCS waves. This introduction to the NCS-IV symposium describes NCS-IV methodology and special features of the new data. The three symposium articles present NCS-IV results about congregations’ political activities, racial and ethnic composition, and worship practices.  相似文献   
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Bioethicists have articulated an ideal of shared decision making between physician and patient, but in doing so the role of clinical uncertainty has not been adequately confronted. In the face of uncertainty about the patient's prognosis and the best course of treatment, many physicians revert to a model of nondisclosure and nondiscussion, thus closing off opportunities for shared decision making. Empirical studies suggest that physicians find it more difficult to adhere to norms of disclosure in situations where there is substantial uncertainty. They may be concerned that acknowledging their own uncertainty will undermine patient trust and create additional confusion and anxiety for the patient. We argue, in contrast, that effective disclosure will protect patient trust in the long run and that patients can manage information about uncertainty. In situations where there is substantial uncertainty, extra vigilance is required to ensure that patients are given the tools and information they need to participate in cooperative decision making about their care.  相似文献   
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