微流控分析芯片在循环肿瘤细胞检测中的运用

随着人们对于肿瘤性疾病的发生、发展、转移机制的进一步探索,循环肿瘤细胞（CTCs）逐渐进入人们视野,其应用价值日益体现,可用于肿瘤性疾病的早期诊断及治疗效果的监测,尤其是对于早期肿瘤的诊断具有独特优势。其富集技术及检测方法也在发生着日新月异的变化。近年来,微流控分析芯片技术运用于 CTCs 的富集及检测,具有高丰度、高富集度、高活性及不需要对样本进行预处理等优点使得人们聚焦于此技术,本文对微流控分析芯片在 CTCs 检测中的运用做简要综述。     

基于结构方程模型的多重中介效应分析

多重中介模型是指存在多个中介变量的模型。多重中介模型可以分析特定中介效应、总的中介效应和对比中介效应。指出了目前多重中介模型分析普遍存在的问题,包括分析不完整、使用Sobel检验带来的局限。建议通过增加辅助变量的方法进行完整的多重中介效应分析,使用偏差校正的Bootstrap方法进行中介检验。总结出一个多重中介SEM分析流程,并有示例和相应的MPLUS程序。随后展望了辅助变量和中介效应检验方法的发展方向。     

青少年大五人格对网络成瘾的影响:家庭功能的中介作用

目的:探究家庭功能在人格特征与网络成瘾之间的中介作用。方法:973名中学生被试完成基本人口学问卷、网络成瘾量表、人格五因素问卷、家庭功能评定量表。结果:(1)人格特征可以显著预测网络成瘾。其中,情绪性人格可以显著正向预测网络成瘾,责任心、宜人性显著负向预测网络成瘾。(2)家庭功能在情绪性、责任心对网络成瘾的影响具有部分中介作用、在宜人性对网络成瘾的影响具有完全中介作用。结论:在治疗中,可针对网络成瘾者的家庭功能进行积极干预,从而减轻其成瘾症状。     

Do Subtle Linguistic Interventions Priming a Social Identity as a Voter Have Outsized Effects on Voter Turnout? Evidence From a New Replication Experiment

An ongoing debate in political psychology is about whether small wording differences have outsized behavioral effects. A leading example is whether subtle linguistic cues embedded in voter mobilization messages dramatically increase turnout. An initial study analyzing two small‐scale field experiments argued that describing someone as a voter (noun) instead of one who votes (verb) increases turnout rates 11 to 14 points because the noun activates a person's social identity as a voter. A subsequent study analyzing a large‐scale field experiment challenged this claim and found no effect. But questions about the initial claim's domain of applicability persist. The subsequent study may not have reproduced the conditions necessary for the psychological phenomenon to occur, specifically the electoral contexts were not competitive or important enough for the social identity to matter. To address the first of these critiques, as well as other potential explanations for different results between the first two studies, we conduct a large‐scale replication field experiment. We find no evidence that this minor wording change increases turnout levels. This research provides new evidence that the strategy of invoking the self does not appear to consistently increase turnout and calls into question whether subtle linguistic cues have outsized behavioral effects.     

Longitudinal Associations between Oppositional Defiant Symptoms and Interpersonal Relationships among Chinese Children

Children with oppositional defiant disorder (ODD) are at increased risk for developing poor relationships with people around them, but the longitudinal links between ODD symptoms and subsequent interpersonal functioning remain unclear. In the current study, we examined the bidirectional associations between ODD symptoms and children’s relationships with parents, peers, and teachers. We included separate analyses for parent vs. teacher reports of ODD symptoms, with regard to subsequent interpersonal relationships. Participants included 256 children with ODD, recruited in China, along with their parents and teachers, assessed at three time points roughly two years apart. Parents and teachers reported child ODD symptoms at each time point, and children reported their perceptions of father– and mother–child attachment, peer relationships, and teacher–student relationships across the three time points. ODD symptoms reported either by parents or teachers predicted impairments in interpersonal functioning. Meanwhile, child interpersonal impairments with peers and teachers predicted subsequent increase in teacher-reported ODD symptoms. These findings highlight the importance of transactional models of influence—and of considering early intervention for ODD in protecting children from developing further deficits and impairments. Additionally, we discuss the perspectives of multiple informants on ODD symptoms, including their different patterns of association with subsequent interpersonal relationships.     

负性生活事件对初中生自我伤害行为的影响:有调节的中介效应

采用负性生活事件量表、自我批评量表、亲子关系量表和青少年自我伤害行为问卷对333名初中生进行测查,探讨负性生活事件对初中生自我伤害行为的影响及作用机制。结果表明:(1)负性生活事件对初中生的自我批评和自我伤害行为均有显著的正向预测作用;(2)自我批评在负性生活事件与初中生自我伤害行为之间起着部分中介作用;(3)负性生活事件和自我批评的关系(中介效应的前半段路径)受到亲子关系的调节,即负性生活事件对自我批评的正向影响随着父子关系和母子关系的增强而减弱。因此,负性生活事件和初中生自我伤害行为之间存在有调节的中介效应。     

前瞻记忆的情绪一致性反转效应

采用经典双任务实验范式,探讨前瞻记忆的情绪一致性效应及其理论模型。情绪电影片段诱发被试高兴或悲伤情绪后,观察被试在高兴、悲伤和自然情绪状态下的前瞻记忆任务和当前任务的成绩。结果发现,情绪一致性前瞻记忆出现反转效应,即在高兴背景下前瞻记忆负性词比正性词成绩好,在悲伤背景下前瞻记忆正性词比负性词成绩好。实验结果支持前瞻记忆的注意—搜索模型,不支持自动激活模型。     

恋人概念威胁启动削弱自我和恋人面孔优势效应:来自眼动研究的证据

采用眼动记录技术和恋人概念威胁启动范式探讨自我和恋人面孔优势效应的产生和维持过程。结果发现:与概念非威胁启动条件下相比,概念威胁启动条件下,被试搜索恋人面孔时的兴趣区个数和搜索自我面孔时的平均眼跳次数与搜索陌生人面孔时比差异变得不显著;恋人面孔与陌生人面孔在兴趣区内总注视时间上的差异变得不显著。结果表明,自我与恋人面孔存在注意的优先捕获和维持优势,恋人概念的威胁启动会减少对恋人的关注,证明了建立恋人的积极概念是恋人面孔优势效应产生和维持的重要原因。