核黄素对食管癌预防和治疗作用的研究

核黄素缺乏是导致食管癌发生的主要危险因素之一,补充核黄素可以有效降低食管癌发病风险,但这一作用存在明显个体差异,从而限制了核黄素补给在食管癌变预防和治疗中的应用.食管癌全基因组关联分析发现核黄素转运基因C20orf54是食管癌的重要易感基因之一,后者对核黄素有效转入细胞内起重要作用,提示C20orf54基因变异可能是导致补充核黄素预防食管癌存在个体差异的主要原因,对补充核黄素预防和治疗食管癌变提供理论指导.核黄素缺乏(环境因素)和基因变异(遗传因素)对食管癌发生的影响进一步揭示食管癌的发生是内因和外因交互作用的结果.     

国外护理硕士教育与临床实践效果的研究现状

通过文献分析法,一方面探讨美国、英国、日本、泰国护理硕士研究生的招收条件、培养目标与课程设置、综合评定考核方法等,了解国外护理硕士培养机制;另一方面分析国外护理硕士课程对临床护理的影响,以及毕业后从事临床护理的实践效果和临床工作中面临的挑战,以期为我国护理硕士教育的发展提供借鉴.     

腹腔镜在女性盆底修复术中的应用

随着社会老龄化的加剧,盆底功能障碍性疾病的发病率日益上升.之前热门的盆底重建术随着时间的推移,并发症相继出现.美国食品药品管理局(FDA)连续两次发布了关于经阴道网片的警告,使专家们认识到了问题的严重性.经过30余年的发展,腹腔镜技术已经被广泛地应用于各类妇科手术中.腹腔镜在女性盆底修复术中的应用重新得到了关注.自1991年腹腔镜技术首次应用于女性盆底修复手术中以来,国内外不断有新的腹腔镜下盆底修复术式的报道.现就各种腹腔镜下盆底修复手术做一综述.     

海峡两岸大学生生命意义比较研究——以广州市与台中市为例

该研究以广州市与台中市大学生为被试,抽取500人为预测样本及800人为正式施测样本,通过探索性因素分析和验证性因素分析编制生命意义量表,并通过t检验和潜在剖面分析考察两岸大学生生命意义现况的差异.结果表明：（1）编制的生命意义量表由存在意义、追寻意义、存在盈实、苦难接纳、死亡接纳以及求意义的意志等6个维度组成,具有良好的信度和效度.（2）两岸大学生生命意义总体无显著差异;存在盈实、苦难接受与死亡接纳维度有显著或非常显著的差异.（3）潜在剖面分析结果显示,两岸大学生生命意义类型相似.Wald检验结果表明,对于“死亡接纳”维度,台湾与大陆学生在各潜在类别的均分上存在显著的差异.     

Intuitive Conceptions of Dead Persons' Mentality: A Cross-Cultural Replication and More

Jesse Bering (2002) investigated how American university students in an interview task conceived of dead persons' mentality immediately after death. He found that different categories of mental states or capacities were conceived differently: psychobiological and perceptual states ceased, whereas emotional, desire, and epistemic states continued. Our Study 1 was a replication of Bering's experiment in a different cultural setting, in which the subjects were Chinese undergraduate students. A similar pattern of results was found. In Study 2, instead of being asked about a dead person's various mental states immediately following the death, participants were asked to judge a dead person's mental states after the person had been dead for 2 days. The overall pattern of participants' responses was not affected by this manipulation, but they did show an increase in attributions of certain mental states to dead agnostics. In addition, a more refined breakdown of responses revealed that individuals tended to judge that, upon death, visual and auditory perception continued, whereas olfactory and gustatory sensation ceased.     

The development of social value orientation across different contexts

This study aimed to explore Chinese children's social value orientation across different ages and contexts. Revised decomposed games were used to measure the social value orientation of 9‐, 11‐, and 14‐year‐old children and college students as an adult group. About half of them were assigned to the hypothetical context of “equal payment group,” providing equal compensation for participation in the study, and the others to the “real payment group,” who got payment according to their own choices in the games. Results showed that 9‐ and 11‐year‐old children's choices differed between the two contexts: They made more prosocial choices in the hypothetical context, and more competitive choices in the “real payment” context. The 14‐year‐olds’ and adults’ choices were not significantly different in the two contexts. These results may imply that by 14 years of age, children have stable social value orientation, and their behavior reflects this value.     

How Speech Modifies Visual Attention

Auditory distractions can have serious consequences in critical situations such as driving. Mobile phones, radios, media players, and information devices that interpret and produce speech are increasingly common in vehicles, but the threats to visual attention are not yet fully understood. In three experiments, we found that most speech tasks had relatively small adverse effects on the detection of a briefly presented target among distractors across a 60° subarea of the visual field. Although there was a little impact on detectability, moderately difficult speech tasks slowed responding relative to silence. Our most demanding condition—generating and speaking a word beginning with the last letter of another word—had the greatest effects on accuracy and latency, with responding slowed by about 900 ms. An impairment of this magnitude presents a significant threat to safe driving and calls into question the belief that hands‐free voice‐controlled devices are the answer to the problem of driver distraction. Copyright © 2013 John Wiley & Sons, Ltd.     

Core Knowledge Employee Creativity and Firm Performance: The Moderating Role of Riskiness Orientation,Firm Size,and Realized Absorptive Capacity

In this study, we examine when creativity is positively or negatively related to firm performance. Building on the creation–implementation tension theorized in the literature and the attention capacity perspective, we argue that the relationship between creativity and firm performance is contingent on riskiness orientation, firm size, and realized absorptive capacity. Data were collected from 761 core knowledge employees, 148 CEOs, and 148 HR executives from 148 high‐technology firms. The results indicated that core knowledge employee creativity was negatively related to firm performance when riskiness orientation was high. The relationship was positive when realized absorptive capacity was high. Finally, the relationship was more positive in small firms than in large firms. We discuss the implications of our findings for creativity research and managerial practices.     

汉语学龄前儿童正字法意识的发展

本研究选择北京地区幼儿园3岁、4岁、5岁儿童各31、48、33名, 采用单部件意识测验和部件位置及功能意识测验系统探查了学龄前儿童的正字法意识各个层面的发展状况。单部件意识测验包括部件替换、部件缺失和部件旋转三个部分; 部件位置及功能意识测验分为假字和非字两个部分, 而非字又包括两形非字和形声非字。结果发现单部件意识测验中, 5岁组儿童在部件替换水平上的得分显著高于3岁组儿童, 而3岁组与4岁组、4岁组与5岁组儿童之间无显著差异; 部件缺失和部件旋转水平上, 三个年龄段的儿童的得分表现出明显的增长趋势。部件位置及功能意识测验中, 假字得分在三个年龄段之间无显著差异; 非字得分随年龄增长显著提高。这些结果表明, 单部件意识在学前期处于不断发展的阶段, 其中对部件替换的非字的拒绝能力发展较早, 部件缺失和部件旋转非字的拒绝能力发展较晚; 部件位置及功能意识在学前期已经开始发展, 3岁儿童已经具有假字符合正字法规则的认识, 但对非字违反部件位置合法性和功能完整性的认识直到4岁左右才开始萌芽, 5岁还未成熟。     

伤害回避的脑机制及其生物基础

伤害回避是指个体对厌恶刺激信号做出强烈的反应,并学会被动地回避惩罚的一种倾向,这一倾向使得个体反复思考未来的结局,并谨慎小心地对待不确定情景中的事件,进而更有可能诱发情感障碍。伤害回避涉及的神经网络包括三个子网络,即额顶叶-前扣带皮层的连接、皮层-杏仁核的连接和白质通道的结构性连接,这三个子网络分别与羞怯感-易疲劳性、预期担心以及不确定环境中的害怕情绪有关。而其生物基础则包括单一基因多态性和基因多态间的交互作用。今后的研究应该集中在深化伤害回避神经网络与生物基础间的联合机制、研究三种及以上基因多态间的交互作用、考察其他因素对基因效应的调节作用、注重伤害回避四种亚型相关神经网络之间的连接、探讨5-HT4等其他几种5-羟色胺受体多态性与伤害回避的关系以及分析伤害回避内部机制在抗抑郁治疗中的作用等方面。