A Psychoneuroimmunologic Perspective on AIDS Research: Questions,Preliminary Findings,and Suggestions1

Starting with the premise that research questions emanating from the fields of psychoneuroimmunology and behavioral medicine may provide critical information for understanding and treating acquired immune deficiency syndrome (AIDS), we provide brief backgrounds on psychoneuroimmunology and on AIDS. Previously, Solomon had generated 25 hypotheses based on the thesis that the immune and central nervous systems are intimately linked. Eight hypotheses from his list are presented as particularly relevant to AIDS. From these hypotheses, we derived a set of 12 new questions to be addressed in research on AIDS. Evidence and illustrations from studies in the literature, from our own research on psychoimmunologic relationships and psychosocial factors related to outcome, and from clinical examples is discussed for each question. Finally, suggestions are offered to address some of the problems in conducting psychoneurologic research.     

USE OF ESCAPE AND REWARD IN THE MANAGEMENT OF YOUNG CHILDREN DURING DENTAL TREATMENT

A reinforced practice procedure was used to facilitate cooperative behavior in five children, aged 3 to 6 years, during dental treatment. In a multiple baseline design across subjects, the children were rewarded with escape, inexpensive stickers, and praise for cooperative behavior in the presence of the sights, sounds, and some sensations of the dental instruments prior to actual dental treatment. Direct observations of disruptive behavior via a 15-s interval recording system indicated baseline levels as high as 90% were reduced to less than 15% by the final treatment visit. In addition, the procedure was effective in reducing overall heart rate and blood pressure reactivity to dental treatment. All children were rated by the involved dental professionals as more cooperative and relaxed following exposure to reinforced practice.     

Accelerated development of cardiac sympathetic responses in spontaneously hypertensive (SHR) rats

The functional development of cardiac and adrenal medullary responses to reflex activation of the sympathetic nervous system was studied in preweanling spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats. Pups of the two strains received injections of insulin or saline at 2, 4, 8, 12, or 16 days of age and were sacrificed 3 h later. Insulin administration produces a significant decrease in circulating levels of glucose which in turn results in a centrally mediated increase in sympathetic outflow. The induction of ornithine decarboxylase (ODC) in heart and the depletion of epinephrine from the adrenal medulla served as tissue markers of functional sympathetic neurotransmission. WKY and SHR pups had comparable levels of ODC activity in heart under basal conditions. In contrast, levels of catecholamines in the adrenals were greater in SHR pups at 2 and 4 days of age. Following insulin administration, SHR pups exhibited a greater induction of cardiac ODC activity at 2, 4, and 8 days of age compared to age-matched WKY controls. However, there were no differences between SHR and WKY pups in the magnitude of the adrenal medullary response to insulin-induced hypoglycemia. These alterations in sympathetic-target tissue development during the first postnatal week of life may contribute in part to the higher arterial pressures maintained by SHRs throughout the lifespan.     

Sexual experience and preference for males or females in the female rat

The influence of sexual experience on preference behavior was investigated in adult female rats. In the first experiment, preference behavior for sexually active males versus estrous females was investigated in female rats who were experienced with mounting behavior. Preference of these mount experienced females was compared to preference of females who were naive in this respect. Mount experience with estrous females induced a female-directed preference in ovariectomized female rats, irrespective of whether the females were treated with OIL or with testosterone-propionate (500 micrograms TP, injected once 48 h prior to testing). Sexually naive, OIL-treated females did not show a preference for males or females, but TP induced a preference for a male. Individual differences in mount frequency were not correlated with preference behavior. In the second experiment, the influence of experience with feminine sexual responses on preference behavior was investigated. OIL-treated and TP-treated females oriented equally toward males and females when they had been given the opportunity to copulate with males prior to the preference tests. The results strongly suggest that prior sexual experience is an important determinant of preference behavior. The female's behavior during sexual interactions was, however, not predictive of later preference.     

Time went by so slowly: Overestimation of event duration by males and females

In three experiments, 469 subjects watched a short videotape of a bank robbery and later estimated the duration of the tape. Subjects invariably overestimated the durations. Accuracy of time estimation was unrelated to amount of free recall (Experiment 1) or accuracy of memory (Experiment 2). Females overestimated to a greater degree than males (Experiments 2 and 3). A more stressful version of the event produced greater overestimates than a less stressful version (Experiment 3). The relationship between induced arousal and time estimation appears to be different for men and women.     

Counseling in Malaysia: An Emerging Profession

The emergence of counseling in Malaysia illustrates the importance of a strong professional association and counseling training programs at the university level.     

Automatic detection of transient potentials in the EEG

A classifier based on the linear regression model was developed to automatically detect sharp transients in EEG, matching the definition of spikes and sharp waves accepted by IFSECN. Practical applications proved the accuracy of the method which succeeded in detecting 84% of sharp transients previously found by an experienced electronencephalographer. Computerized search for sharp transients in EEG records will be particularly useful in long term EEG records obtained from epileptic patients.