Clinical trial of contemnol tablets (lithium retard Spofa)

A report on the clinical testing of the lithium-retard medicament Contemnol (Spofa). It details the way lithium-retard treatment is objectively and subjectively superior to the earlier and still current general lithium treatment.     

Status of perfusion scintigraphy in the diagnostic strategy in cerebrovascular disorders and space-occupying lesions

The results of an evaluation of the perfusion scintigraphy findings of 350 hospitalised neurological patients and 55 more strictly selected neurosurgical patients with cerebrovascular complaints, revealed an accuraty of 83%, a sensitivity of 89%, and a specificity of 83%. The selection of the patients had no influence on the results as a whole. Compared with contrast-medium angiography, incorrect diagnosis must be expected in 17% of the cases. This includes erroneous negative findings in 10% of the cases. Grounds for misinterpretations are suggested, and the biological and methodological limitations of the method are set forth.     

Diagnostic value of myelography as an expanded clinical study method

The paper investigates 54 myelograms and their influence on diagnostic thinking efficacy, on patient management efficacy, and on ultimate outcome efficacy, using statistical methods. Conventional myelography contributes to diagnostic thinking efficacy having a LLR- value of approximately 0.9. With an accuracy value of 0.95 it can be regarded as a reliable method of diagnosis. It alters diagnostic thinking efficacy in no less than 83% (94%) of the cases and patients management efficacy in 89%. Thus, by definition, myelography may be said to affect the state of health of the myelographed patients in 94.4%.     

Psychopathology of progressive paralysis. Remarks on some personal cases

Four of our own cases that presented a clinical picture of dementia are discussed. A study of the relative literature has failed to reveal any "swing" in the pattern of the clinical condition: Just as it did ninety years age, paralytic dementia accounts today for well over 60% of all cases, those clinical pictures erroneously regarded as "typical" "classic", accounting for a mere 10%-15% of cases. The need for routine lues serology is pointed out.     

Flicker contrast sensitivity in normal and specifically disabled readers

Temporal contrast sensitivity for counterphase flicker was determined for specifically disabled and normal readers to investigate whether the two groups differ in the functioning of their transient systems. In experiment 1, temporal contrast sensitivity was measured over a range of temporal frequencies with a spatial frequency of 2 cycles deg-1. Disabled readers were less sensitive than the control subjects at all temporal frequencies. In experiment 2, temporal contrast sensitivity was measured at a temporal frequency of 20 Hz over a range of spatial frequencies. Disabled readers were less sensitive than the controls at all spatial frequencies, with the differences between the groups increasing as spatial frequency increased. Both these findings are interpreted as supporting the hypothesis of a transient-system deficit in the visual systems of disabled readers.     

Brain potentials as indices of orthographic and phonological interaction during word matching

The interaction between orthographic and phonological codes in a same-different judgment task was studied by requiring subjects to decide if two visually presented words either looked alike or rhymed. Word pairs were selected from four different lists. Words rhymed and looked alike, rhymed but did not look alike, looked alike but did not rhyme, or neither looked alike nor rhymed. Reaction time and percent error increased whenever there was a conflict between the orthography and phonology of the words. The N200 component of the event-related brain potential (ERP) indicated that subjects were capable of detecting phonological differences between words within 260 ms from the presentation of a word pair. The amplitude of the N200s also varied with the degree of mismatch between words. N200s were largest when both the orthography and phonology mismatched, of intermediate amplitude when either orthography or phonology mismatched, and smallest when both orthography and phonology matched. P300 latency was consistent with reaction time, increasing whenever there was a conflict between the two codes. Taken together, behavioral measures and the ERP data suggest that the extraction of the orthographic and phonological aspects of words occurs early in the information processing sequence.     

The influence of individual and family characteristics upon career aspirations of girls during childhood and adolescence

The term pioneer is used for girls aspiring to male-dominated careers. This longitudinal study assesses the career choices of 68 middle-class girls during childhood (8–13 years, Phase I) and again during adolescence (13–18 years, Phase II), and investigates the relation between pioneering career choice and personal and family characteristics. Subjects were originally selected for exposure vs nonexposure to exogenous hormones during pregnancy. In childhood, pioneers were somewhat older, were more often persistent tomboys, had higher IQs, and had parents with higher educational attainment. In adolescence, paternal education was the only variable that showed the same relation to career choice. Adolescent girls who had wanted to get married at the time of the childhood assessment were now less likely to choose pioneering careers. Adolescent pioneers also had higher educational aspirations than nonpioneers and less likely anticipated being married within ten years than nonpioneers. A number of statistically borderline relationships were also observed: pioneers had somewhat fewer older brothers than nonpioneers, less often came from homes in which traditional femininity was stressed, and more frequently had mothers who had worked outside the home throughout their daughters' school years than mothers of nonpioneers. Prenatal exposure to exogenous sex hormones was not related to career choice during either childhood or adolescence.     

Prevalence of DSM-III conduct and adjustment disorders for adolescent psychiatric inpatients

The prevalence of DSM-III conduct and adjustment disorders in two adolescent psychiatric facilities, both located near large U.S. cities, was investigated. Overall, 31.6% of the adolescent inpatients were conduct disordered while 12.5% were adjustment disordered. The conduct disorders were primarily "aggressive" subtypes suggesting that this characteristic may influence hospitalization and diagnostic decisions. Such data on prevalence assists future treatment planning, allowing anticipation of case loads.