Validity of post-proline splitting dipeptidyl aminopeptidase activities in the cerebrospinal fluid for neurologic and psychiatric diagnosis

The dipeptidyl-peptidase activity of 650 liquores cerebrospinalis was obtained by means of the substrate Gly-Pro-NHNp (Gly-Pro-4-nitroanilid) at pHs of 5.5 and 7.4. In comparison with a reference collective, the suitability of the method as a supplementary liquor parameter in neurological psychiatric diagnosis was examined. The introduction of the measurement at pH 7.4 can be particularly recommended for the distinguishing of bacterial and nonbacterial meningitis.     

Foundations of a new system of probability theory

The aim of my book is to explain the content of the different notions of probability.Based on a concept of logical probability, which is modified as compared with Carnap, we succeed by means of the mathematical results of de Finetti in defining the concept of statistical probability.The starting point is the fundamental concept that certain phenomena are of the same kind, that certain occurrences can be repeated, that certain experiments are identical. We introduce for this idea the notion: concept K of similarity. From concept K of similarity we derive logically some probability-theoretic conclusions:If the events E() are similar —of the same kind - on the basis of such a concept K, it holds good that intersections of n of these events are equiprobable on the basis of K; in formulae: E(₁)...E( _{n K} E('₁)...E(' _n , _{i j} ,' _j ' _j for ij On the basis of some further axioms a partial comparative probability structure results from K, which forms the starting point of our further investigations and which we call logical probability on the basis of K.We investigate a metrisation of this partial comparative structure, i.e. normed -additive functions m _K, which are compatible with this structure; we call these functions m _K measure-functions in relation to K.The measure-functions may be interpreted as subjective probabilities of individuals, who accept the concept K.Now it holds good: For each measure-function there exists with measure one the limit of relative frequencies in a sequence of the E().In such an event, where all measure-functions coincide, we speak of a quantitative logical probability, which is the common measure of this event. In formulae we have: l _K (h _n lim h _n )=1 in words: There is the quantitative logical probability one that the limit of the relative frequencies exists. Another way of saying this is that the event ^* (h_n lim h _n) is a maximal element in the comparative structure resulting from K.Therefore we are entitled to introduce this limit and call it statistical probability P.With the aid of the measure-functions it is possible to calculate the velocity of this convergence. The analog of the Bernoulli inequation holds true: m _K (¦h _n –P¦)1–1/4n².It is further possible in the work to obtain relationships for the concept of statistical independence which are expressed in terms of the comparative probability.The theory has a special significance for quantum mechanics: The similarity of the phenomena in the domain of quantum mechanics explains the statistical behaviour of the phenomena.The usual mathematical statistics are explained in my book. But it seems more expedient on the basis of this new theory to use besides the notion of statistical probability also the notion of logical probability; the notion of subjective probability has only a heuristic function in my system.The following dualism is to be noted: The statistical behaviour of similar phenomena may be described on the one hand according to the model of the classical probability theory by means of a figure called statistical probability, on the other hand we may express all formulae by means of a function, called statistical probability function. This function is defined as the limit of the relative frequencies depending on the respective state of the universe. The statistical probability function is the primary notion, the notion of statistical probability is derived from it; it is defined as the value of the statistical probability function for the true unknown state of the universe.As far as the Hume problem, the problem of inductive inference, is concerned, the book seems to give an example of how to solve it.The developed notions such as concept, measure-function, logical probability, etc. seem to be important beyond the concept of similarity.The present work represents a summary of my book Grundzüge zu einem neuen Aufbau der Wahrscheinlich-keitstheorie [5], For this reason, I have frequently dispensed with providing proof and in this connection refer the interested reader to my book.     

Determination of dipeptidyl aminopeptidase activities in the cerebrospinal fluid

The investigation of enzyme activity in cerebrospinal fluid has been without relevant results for laboratories analysing spinal fluid. For neurochemical purposes, it is interesting that the Substance P is convered by Depeptidyl-aminopeptidase IV (DP IV), liberating dipeptides. The hydrolysis of nitroanilids of the form Xaa-Pro-NHNp in cerebrospinal fluid was analysed using them as peptidases substrates. Finally a method for measuring the activity was proposed.     

Catamnestic surveys on somato-psychosocial development in childhood and adolescence of patients with unipolar depressive and bipolar manic-depressive psychoses

The somatic and psychosocial development of 80 subjects with manifest affective-phasic psychoses is studied retrospectively and compared with that of an identically sized control group consisting of neuropsychiatrically healthy subjects. Statistically significant differences were found particularly in the answers to questions dealing with social situation and social adaptability. Achievement at school and vocational qualifications were lower among the parents of the patients than among those of the healthy subjects. Characteristic features of the patients' childhood and adolescence were transient depression, often for no apparent cause, and maladaption, and vocational wishes were fulfilled less often than among the controls. The patients experienced greater difficulty in settling in to a new group due to their contact difficulties.     

Competition and Justice in Adam Smith

This article analyzes the relationship between competition and justice in Adam Smith in order to determine to what extent competition can promote and undermine justice. I examine how competition features in two basic motivations for human action, “the propensity to truck barter and exchange,” and “the desire of bettering our condition.” Both can be traced back to the desire for recognition, but they operate in very different ways. The former manifests itself in social cooperation, chiefly commercial exchange and the division of labor, and while it can take a competitive form, competitive success produces benefits for everyone. In contrast, the latter may manifest itself in win-lose social competition. Commercial society harnesses both motivations, and both have negative as well as positive effects. However, while Smith explicitly addresses the negative effects of excessive specialization in the division of labor, it is less clear how he thinks the negative effects of social competition can be addressed. I argue that competition can undermine justice when (i) it pits people against each other and (ii) leads to psychological corruption. I conclude with some reflections on what a focus on competition adds to our understanding of Smith's work.     

A systematic review of relationship sacrifices from 2002 to 2021: Moving toward inclusivity

We conducted a systematic review of research on relational sacrifices in romantic relationships from 2002 to 2021 [N = 115 studies] to answer three questions: Q1: Whose voices and vantage points are represented in the research?; Q2: What types of questions are valued?; Q3: What are the reflections and connections about relational sacrifices that were learned during the review? To address Q1, we coded sample demographics of study participants on geographical location, race/ethnicity, education/income/SES, gender (i.e., gender differences explored and beyond gender binaries), sexual orientation, age, and disability, using a coding system of 1 (exclusion/absence) to 5 (focus on context-relevant experiences for underrepresented samples). Results for Q1 showed that the most frequent codes were 1 (exclusion/absence) for information about the samples' disability status, education/income/SES, and both codes for gender (i.e., gender differences explored and beyond gender binaries); when demographic information was reported, the most frequent codes were 2 (compensatory addition) for age, sexual orientation, geographical location, and race/ethnicity. To address Q2, we coded for aspects of the study designs and conceptual dimensions of sacrifice. Results for Q2 showed that a majority of the studies in our review used quantitative and close-ended measures emphasizing behavioral frequency of sacrifice. For Q3, we include our own reflections and connections about relational sacrifices, questioning research methods, and challenging assumptions drawn from existing research to move toward a more inclusive science.     

Heterogeneous heterogeneity by default: Testing categorical moderators in mixed-effects meta-analysis

Categorical moderators are often included in mixed-effects meta-analysis to explain heterogeneity in effect sizes. An assumption in tests of categorical moderator effects is that of a constant between-study variance across all levels of the moderator. Although it rarely receives serious thought, there can be statistical ramifications to upholding this assumption. We propose that researchers should instead default to assuming unequal between-study variances when analysing categorical moderators. To achieve this, we suggest using a mixed-effects location-scale model (MELSM) to allow group-specific estimates for the between-study variance. In two extensive simulation studies, we show that in terms of Type I error and statistical power, little is lost by using the MELSM for moderator tests, but there can be serious costs when an equal variance mixed-effects model (MEM) is used. Most notably, in scenarios with balanced sample sizes or equal between-study variance, the Type I error and power rates are nearly identical between the MEM and the MELSM. On the other hand, with imbalanced sample sizes and unequal variances, the Type I error rate under the MEM can be grossly inflated or overly conservative, whereas the MELSM does comparatively well in controlling the Type I error across the majority of cases. A notable exception where the MELSM did not clearly outperform the MEM was in the case of few studies (e.g., 5). With respect to power, the MELSM had similar or higher power than the MEM in conditions where the latter produced non-inflated Type 1 error rates. Together, our results support the idea that assuming unequal between-study variances is preferred as a default strategy when testing categorical moderators.     

Choice behavior and the accessibility of the reinforcer

In Experiment 1, matching of relative response rates to relative rates of reinforcement was obtained in concurrent variable-interval schedules when the absolute values of the two concurrent variable-interval schedules varied from 6 sec and 12 sec to 600 sec and 1200 sec. Increases in the duration of the changeover delay, however, produced decreases in the relative response rates and, consequently, some deviation from matching. In Experiment 2, matching of relative response rates to the relative duration of the reinforcer failed to occur when the equal variable-interval schedules arranging access to the two different reinforcer durations (1.5 and 6 sec) were varied in size from concurrent variable-interval 10-sec schedules to concurrent variable-interval 600-sec schedules.     

Differential-psychologische Untersuchungen zum Vigilanzverhalten

Zusammenfassung Mit Hilfe von Korrelationsmethoden wurden inter-individuelle Leistungsunterschiede in einer ein- und einer mehrflächigen Vigilanzaufgabe untersucht. In beiden Aufgaben korrelieren bestimmte Vigilanzscores mit Interferenzindikatoren im Stroop-Versuch. In der mehrflächigen Anordnung zeigte sich eine negative Korrelation zwischen der Entdeckungswahrscheinlichkeit und der Rate der falschen Alarme. Hinsichtlich der zeitlichen Merkmale der Vigilanzleistung ergab sich, daß die Vpn den geringsten Abfall der Entdeckungswahrscheinlichkeit erkennen lassen, die zu Beginn der Vigilanzaufgabe die Rate der falschen Alarme am stärksten reduzieren konnten. Die Ergebnisse wurden im Rahmen des detection-Modells interpretiert.

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Experiments in individual differences of vigilance behavior

Summary This paper is concerned with individual differences of vigilance performance in a simple and a complex vigilance task. In both tasks certain aspects of vigilance behavior were correlated with interference in the Color Word Test by Stroop. In the complex vigilance task there was a negative correlation between the probabilities of signal detections and false alarms rates. With regard to the temporal characteristics of vigilance behavior it was found out that subjects with the least decrease of detection rate showed the greatest reduction of their false alarms rate to the beginning of the vigilance task. The results were discussed in the context of the detection model.

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Teil II der Dissertation, die im Januar 1969 der Philosophischen Fakultät der Freien Universität Berlin vorgelegt wurde.