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51.
Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning 下载免费PDF全文
The current study examined the effects of globally depleting Purkinje cells in the cerebellar cortex with the immunotoxin OX7-saporin on acquisition and extinction of delay eyeblink conditioning in rats. Rats were given OX7-saporin or saline 2 wk before the start of eyeblink conditioning. The rats that reached a performance criterion of two consecutive days with 80% or greater conditioned responses were given 5 d of extinction training followed by 2 d of reacquisition training. Rats that received infusions of OX7-saporin had 77.2%-97.9% Purkinje cell loss and exhibited impaired acquisition and extinction. The amount of Purkinje cell loss was correlated with the magnitude of the acquisition and extinction impairments. The highest correlations between Purkinje cell number and the rate of acquisition were in lobule HVI and the anterior lobe. The highest negative correlation between Purkinje cell number and the percentage of conditioned responses during extinction was in the anterior lobe. The results indicate that cerebellar Purkinje cells, particularly in the anterior lobe and lobule HVI, play significant roles in acquisition and extinction of eyeblink conditioning. 相似文献
52.
Hopkins WD Russell JL Freeman H Reynolds EA Griffis C Leavens DA 《Emotion (Washington, D.C.)》2006,6(4):553-559
This study evaluated laterality in scratching by chimpanzees (n = 89) during socially arousing circumstances. Hand use and the side of the body scratched was recorded during a baseline and experimental condition. In the experimental condition, chimpanzees were shown a video of other conspecifics sharing, fighting over, and consuming a watermelon. Self-touches were categorized as either rubs or scratches. The chimpanzees showed a significant right hand bias for rubbing and also significantly directed the rubs to the right side of the body. For scratching, the chimpanzees showed no hand preference but a significant bias for scratching on the left side of the body. These results support the view that the right hemisphere regulates the autonomic nervous system during arousal. 相似文献
53.
Rhesus monkeys (Macaca mulatta) with bilateral ibotenic acid-produced lesions of the amygdala were compared with controls in several novel situations, including exposures to metal objects, toy animals, and a person. Early in testing, the monkeys with lesions showed reduced inhibitions on responsiveness compared with controls. With continuing exposures, differences between groups diminished sharply as inhibitions waned in the controls. This outcome is consistent with the hypothesis that the amygdala mediates caution in initial reactions to ambiguous or threatening novel situations, which, in the absence of adverse consequences, diminishes with repetition. Consistency of individual responsiveness across different situations, including pairing with other monkeys, was substantial in lesioned and normal monkeys, suggesting that stable qualities of temperament influenced the results in both groups. 相似文献
54.
Freeman D Garety P Kuipers E Colbert S Jolley S Fowler D Dunn G Bebbington P 《Behaviour research and therapy》2006,44(8):1147-1158
Clinicians and researchers have suggested that rapidity in belief formation, due to having a high 'need for closure' (NFC), may contribute to the acceptance of delusional explanations. The aim of the study is to determine whether NFC has such a direct link with delusions. A secondary aim is to examine if NFC is related to the delusion-associated reasoning process of 'jumping to conclusions'. One hundred and eighty-seven patients with psychosis, recruited for a treatment trial of psychological therapy (the PRP trial), completed the Need for Closure Scale (NFCS), symptom measures, and probabilistic reasoning tasks. The NFCS was considered in terms of its two dimensions: a desire for simple structure and a preference for quick, decisive answers. The individuals with psychosis reported being poor at making quick, decisive answers but required a greater need for simple structure. NFC was associated with levels of anxiety and depression. There were weak links between NFC and both positive and negative symptoms of psychosis, but these were explained by differences in affect. NFCS scores were unrelated to jumping to conclusions. Contrary to the argument that NFC is directly linked to delusions, individuals with delusions actually perceive themselves as indecisive. There was no evidence that NFC-at least as assessed by the NFCS-could be a proximal cause of delusions. Any potential effect on psychotic symptom presentation is indirect, mediated through affect. The use of the NFCS on its own in the study of psychotic symptoms cannot be recommended. 相似文献
55.
Evelyn Parkin 《The Ecumenical review》2010,62(4):390-398
I will attempt to show the Australian Aboriginal Christian from the spiritual, physical and cultural perspectives. The point that I wish to highlight is that there is an expression of continuity of relationship and ritual sacredness between my ancient people and their Higher Power (known by various names). This relationship is an unbroken thread that has weaved its way through the passages of time. It has been passed on for thousands of years to us here today as Aboriginal Christians. We are not only the “Children of God,” but are also the “Children of the Dreaming”– this is my identity. 相似文献
56.
Evelyn G. Schaefer Michael K. Halldorson Cheryl Dizon-Reynante 《Memory (Hove, England)》2013,21(3):251-266
The flashbulb accounts of 38 participants concerning the September 11th 2001 terrorist attack reported at both 28 hours and 6 months following the event were examined for quantity, quality, and consistency as a function of the time lapse between first learning of the event and initial viewing of media images. The flashbulb accounts of those who reported seeing images at least an hour after learning of the event differed qualitatively, but not quantitatively, from accounts of participants who reported seeing images at the same time as or within minutes of learning of the event. Delayed viewing of images resulted in less elaborate and generally less consistent accounts across the 6-month interval. The results are discussed in terms of factors affecting flashbulb memory formation and individual differences in connectedness to the event. 相似文献
57.
Peter Fischer Joachim I. Krueger Tobias Greitemeyer Kathrin Asal Nilüfer Aydin Evelyn Vingilis 《European Review of Social Psychology》2013,24(1):224-257
Media contents that glorify risk-taking (e.g., video games that simulate illegal street racing, TV depictions of dangerous extreme sports or stunts) are becoming increasingly popular. Theory and research suggest that risk glorification is associated with risk-taking among the audience. Until recently the evidence was limited in three ways: First, most studies, being correlational, did not permit clear causal inferences. Second, we did not know the strength of the effect of different types of media and different types of risk-taking outcomes. Third, early research did little to isolate the underlying psychological processes that mediate the pernicious effects of risk glorifying media formats. In order to address these open questions we review the results of an experimental programme of research and the findings of a comprehensive meta-analysis. The main findings are that (a) the risky media contents do indeed have causal force; (b) according to our meta-analysis active participation in risk glorifying media interfaces has a larger effect than passive consumption; (c) psychological processes include the priming of risk-related constructs, effects of risk-positive situational heuristic cues, perceived social norms, personal risk habituation, and changes in the recipient's self-concept. To integrate these findings we propose a theoretical framework derived from broad-range socio-cognitive models. We conclude with a discussion of possible directions for future research. 相似文献
58.
59.
The primary purpose of the present research was to relate questionnaire-assessed self-reported childhood happiness and events to adulthood happiness in 387 nonclinical participants. Although childhood happiness and adult happiness were found to be significantly correlated (r = .28, p < .001), there was little relationship between reported adult happiness and reported specific childhood events and circumstances. Childhood events and circumstances, however, were much more highly correlated with childhood happiness (R = .64). Thirty-four percent of the persons who said they were unhappy or very unhappy as a child, but only 9% who said they were happy or very happy as a child, reported that they were unhappy or very unhappy as adults. 相似文献
60.
J. Wesley Libb Srdjan Stankovic Roberta Sokol Arthur Freeman Carl Houck Paul Switzer 《Journal of personality assessment》2013,95(1-2):209-218
The Milton Clinical Multiaxial Inventory (MCMI) is a promising, yet somewhat unproven psychometric inventory developed to identify clinical syndromes and personality traits consonant with the Diagnostic and Statistical Manual of Mental Disorders (3rd ed. [DSM-III]; American Psychiatric Association, 1980). The stability of its measures for both the theoretically more stable personality characteristics and the clinical syndromes was investigated in a group of depressed psychiatric outpatients. In this test-retest design with a 3-month interval between tests, clinical syndrome scales of relevance changed significantly as expected. However, many of the personality scales also changed significantly. Only four of the personality scales met a two-fold test of stability. Findings are discussed in terms of characteristics of self-report inventories such as the MCMI, the uniqueness of the depressed population, and characteristics of personality disorders. 相似文献