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101.
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Biomarker discovery has become a central topic in neurodevelopmental research. A validated biomarker could be any objective measure or test that has clinical utility for diagnostic, stratification, or predictive purposes, or that can be used to objectively measure therapeutic efficacy. Here we discuss the potential and challenges of converting tests of fundamental social, cognitive, emotional and motivational processes into clinically useful bio‐behavioral markers for neurodevelopmental conditions. Given the broad clinical and etiological heterogeneity of many neurodevelopmental conditions, we propose moving the focus from identifying group‐defining characteristics to creating cross‐domain bio‐behavioral profiles at the individual level. We outline steps to develop tests that reflect the relevant domains and that are comparable, engaging and sensitive across large age and ability ranges. Analytical validation of these tests requires creating age norms, and optimizing psychometric properties. Individual bio‐behavioral fingerprints of strengths and difficulties across domains can then be combined with multivariate approaches to identify “subgroups.” This may help researchers and clinicians to compare individuals with and without intellectual disability, track developmental stability versus changes, and facilitate family genetic studies. Clinical validation requires including these tests in multidisciplinary, longitudinal and/ or intervention studies to ascertain whether particular subgroups differ in terms of their etiology, clinical symptom profile, prognosis or therapeutic benefit. Potential advantages of bio‐behavioral tests over other biomarker methodologies, such as neuroimaging measures, include the low cost, ease of administration and analysis, low risk, and scalability through on‐line assessments or tablet applications. This article is categorized under:
- Neuroscience > Development
- Psychology > Theory and Methods
- Neuroscience > Clinical Neuroscience
- Neuroscience > Cognition
103.
Stacey M. Kesten Deborah A. Perez Denise S. Marques Scot D. Evans Adrienne Sulma 《American journal of community psychology》2017,60(3-4):450-458
This paper describes the experiences of a research team as they navigated uncertain ethical and political terrain throughout the formative stage of a public housing redevelopment project. Specifically, we discuss the challenges related to balancing multiple accountabilities and the tensions among the various roles and responsibilities that emanated from different accountabilities. Due to contractual obligations to our funding source, established relations with community partners, and an ethical imperative to align with those holding the least power, we grappled with embodying multiple and often conflicting roles. Without oversight provided by our university institutional review board or a clear ethical framework for community psychology research and action, our team was left to negotiate the challenges that emerged through critical reflection and financial considerations. Throughout the case example presented in this paper, we highlight our difficulty in ethical decision‐making with respect to the principles of obligation, disclosure, consent, commitment, and professionalism. Community psychologists often straddle the realms of academia, community partnerships, and conscious engagement with little guidance in navigating often conflicting roles and value systems. We present our narrative to highlight the complexity of scholar‐activism in the context of community psychology and the necessity for developing ethical standards and guidelines tailored to meet the unique needs of community psychologists. 相似文献
104.
Travis C. Evans Katherine A. Walukevich Ilana Seager Jennifer C. Britton 《Anxiety, stress, and coping》2018,31(5):539-554
Background and Objectives: Preferential attention to threat, emotional response inhibition, and attentional control each purportedly play a key role in anxiety disorders. Divergent psychometric properties among attention measures may produce differential detection of anxiety-related associations and treatment-related changes. However, no studies have directly compared the psychometric properties of these attention measures in the same sample.Design: Eighty-five young adults (M?=?19.41 years, SD?=?1.47, 48 Females) completed a cognitive task battery and a subset of 60 participants (M?=?19.42 years, SD?=?1.48, 33 Females) completed the task battery again approximately two weeks later.Method: To assess preferential attention to threat, emotional response inhibition, and attentional control, the cognitive task battery included a dot-probe task, emotion and gender Stroop tasks, and a flanker task. Tasks varied in how attention was directed and if emotional stimuli were included. Internal consistency and test-retest reliability were compared across measures.Results: Within the same sample, internal consistency and reliability differed across attention measures. Explicit attention measures (emotional Stroop and flanker) exhibited stronger internal consistency and greater test-retest reliability compared to implicit measures (dot-probe and gender Stroop).Conclusions: These results inform clinical research using attention measures to assess anxiety-related differences and treatment response. 相似文献
105.
Arielle Borovsky Erica M. Ellis Julia L. Evans Jeffrey L. Elman 《Developmental science》2016,19(6):918-932
Recent research suggests that infants tend to add words to their vocabulary that are semantically related to other known words, though it is not clear why this pattern emerges. In this paper, we explore whether infants leverage their existing vocabulary and semantic knowledge when interpreting novel label–object mappings in real time. We initially identified categorical domains for which individual 24‐month‐old infants have relatively higher and lower levels of knowledge, irrespective of overall vocabulary size. Next, we taught infants novel words in these higher and lower knowledge domains and then asked if their subsequent real‐time recognition of these items varied as a function of their category knowledge. While our participants successfully acquired the novel label–object mappings in our task, there were important differences in the way infants recognized these words in real time. Namely, infants showed more robust recognition of high (vs. low) domain knowledge words. These findings suggest that dense semantic structure facilitates early word learning and real‐time novel word recognition. 相似文献
106.
Igor Linkov Heather Rosoff L James Valverde Matthew E. Bates Benjamin Trump Daniel Friedman Jessie Evans Jeffrey Keisler 《Journal of Multi-Criteria Decision Analysis》2012,19(3-4):155-168
Created by the State Department's Office of the Coordinator for Reconstruction and Stabilization, the Civilian Response Corps (CRC) contains a diverse pool of qualified and ready‐to‐deploy civilian professionals that support conflict prevention and response efforts in countries or regions that are at risk of, are currently in, or are transitioning from conflict or civil strife. As such, it is vital to optimize the CRC's skill groupings to maximize adaptability and responsiveness to highly uncertain and trying political conditions and crises across the globe. The nature of the CRC value proposition is such that determining which skill set compositions deliver the greatest benefit requires a multi‐faceted perspective that looks at a number of attributes and factors, both tangible and intangible. To meet these needs, an organizational decision‐making approach utilizing multi‐criteria decision analysis (MCDA) was applied to ensure that skill‐grouping allocations were determined in a logical and robust manner. The MCDA analysis allowed for a wide range of worldviews and perspectives, drawn from select members of academia and partner agencies of the CRC who provided their expert opinions on the expected demand for skill groupings commonly identified as most necessary in a civilian ‘surge’ capacity. These skills were assessed with reference to a values hierarchy of representative country scenarios, missions and sub‐missions identified by the Office of the Coordinator for Reconstruction and Stabilization. Of particular interest was the use of the MCDA method to prioritize CRC skill groupings and to help inform the Department of State's understanding of the ‘ideal’ proportion and types of civilian skills for inclusion in the CRC. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
107.
Kristie Cramer Holly Tuokko David Evans 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2013,20(3):213-224
Mechanisms for extending autonomy in financial and health care decisions (e.g., advanced directives) are being utilized more frequently. This study examined the hierarchy of documents completed, the characteristics of people completing these documents, the choice of surrogate decision-maker for health care decisions, and with whom health care decisions were being discussed in a sample of 661 persons 65 years of age and older. Comparison between people with and without documents in place suggested that cognitive impairment, level of education, and age were related to preparation of documents. Women were typically chosen as surrogate decision-makers, except in a sample of unmarried men. Surprisingly, participants reported discussing preferences for health care decisions with someone other than their preferred surrogate. There appears to be a need to promote discussion of health care preferences between care-receivers and preferred surrogates. 相似文献
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The ability to accurately assess credibility is important in countless situations, including many in which individuals being assessed are not speaking their native language. There is reason to believe that native and non‐native speakers may behave differently when lying and that detectors may have a bias to believe non‐native speakers are lying. However, very little is known about detecting deception in non‐native speakers, and the few existing studies have not resulted in consistent findings. The current research compared the ability to detect lies and truths in native speakers with that in non‐native speakers and looked at differences in the cues displayed via the Psychologically Based Credibility Assessment Tool. Results from two samples with different demographic characteristics and backgrounds indicated that there was a bias to believe that non‐native speakers were lying. These results may have implications regarding the use of interpreters in settings where credibility is being assessed. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献