Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection

Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer’s disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10 μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50 mg/kg/day, 5 days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD.     

Sex role group differences in specific, academic, and general self-efficacy

The primary purpose of this study was to examine sex role group differences (androgynous, masculine, feminine, and undifferentiated) in three different levels of self-efficacy (general, academic, and course specific). A sample of 215 undergraduate participants completed the three measures of self-efficacy and the sex role measure. Results showed that there was a multivariate significance among the sex role groups in the three levels of self-efficacy and that both masculine and androgynous groups had significantly higher general and academic efficacy means than the undifferentiated or feminine groups. The major findings in this study are largely consistent with findings of previous researchers, supporting the theory that masculinity may be a key construct in the differentiation of individuals in self-efficacy, which has been shown to be an important predictor of achievement.     

Becoming a holistic thinker: training effect of oriental medicine on reasoning

The authors hypothesized that training in Oriental medicine would make students think in a more holistic way. Study 1 found that students of Oriental medicine exhibited a cyclic expectation of future change, a key characteristic of holistic thinking, more than did students in other majors, such that the former, not the latter, believed that if something was going up or going down, it would reverse its direction in the future. Study 2 found that students in Oriental medicine also possessed a more complex causal belief and hence considered a greater amount of information in causal attribution than did students in other majors. More important, such a complex causal belief increased with the length of training in Oriental medicine. Implications and future research are discussed.     

Learning to express motion events in English and Korean: the influence of language-specific lexicalization patterns.

English and Korean differ in how they lexicalize the components of motion events. English characteristically conflates Motion with Manner, Cause, or Deixis, and expresses Path separately. Korean, in contrast, conflates Motion with Path and elements of Figure and Ground in transitive clauses for caused Motion, but conflates motion with Deixis and spells out Path and Manner separately in intransitive clauses for spontaneous motion. Children learning English and Korean show sensitivity to language-specific patterns in the way they talk about motion from as early as 17-20 months. For example, learners of English quickly generalize their earliest spatial words--Path particles like up, down, and in--to both spontaneous and caused changes of location and, for up and down, to posture changes, while learners of Korean keep words for spontaneous and caused motion strictly separate and use different words for vertical changes of location and posture changes. These findings challenge the widespread view that children initially map spatial words directly to nonlinguistic spatial concepts, and suggest that they are influenced by the semantic organization of their language virtually from the beginning. We discuss how input and cognition may interact in the early phases of learning to talk about space.     

Impaired cognitive control during reward pursuit and punishment avoidance

Motivation and Emotion - Two experiments were conducted to examine how cognitive control is modulated by response-contingent reward (Experiment 1) and response-contingent punishment (Experiment 2)....     

Consumer preference for bio‐based batteries

Growing concern about the degradation of the environment and public health has called into question the use of conventional household batteries that are consumed and then typically discarded. Because most conventional batteries are not recycled, they end up in landfills where they decompose, potentially leaching harmful chemicals into the surrounding soil. Bio‐based batteries, which are made from agricultural by‐products, have been designed to help meet the need for household batteries while using sustainable, safe technology. This research examines the links between consumer willingness‐to‐pay (WTP) for bio‐based batteries and consumer characteristics and preferences for certain product attributes and environmentally‐friendly practices. We designed a nationwide survey and analyzed the survey data using the dichotomous‐choice contingent valuation method. The results show an increase in the estimated WTP in the Midwest and South in response to an information treatment about bio‐based batteries. Overall, U.S. consumers concerned about green production and recycling practices are willing to pay a premium for bio‐based batteries. Our results provide essential information for quantitatively assessing the potential market impact of bio‐based batteries, for developing effective management and marketing strategies to reach various consumer groups, and for efficiently establishing sustainable policies and regulations.     

Bayesian Extended Redundancy Analysis: A Bayesian Approach to Component-based Regression with Dimension Reduction

Abstract

Extended redundancy analysis (ERA) combines linear regression with dimension reduction to explore the directional relationships between multiple sets of predictors and outcome variables in a parsimonious manner. It aims to extract a component from each set of predictors in such a way that it accounts for the maximum variance of outcome variables. In this article, we extend ERA into the Bayesian framework, called Bayesian ERA (BERA). The advantages of BERA are threefold. First, BERA enables to make statistical inferences based on samples drawn from the joint posterior distribution of parameters obtained from a Markov chain Monte Carlo algorithm. As such, it does not necessitate any resampling method, which is on the other hand required for (frequentist’s) ordinary ERA to test the statistical significance of parameter estimates. Second, it formally incorporates relevant information obtained from previous research into analyses by specifying informative power prior distributions. Third, BERA handles missing data by implementing multiple imputation using a Markov Chain Monte Carlo algorithm, avoiding the potential bias of parameter estimates due to missing data. We assess the performance of BERA through simulation studies and apply BERA to real data regarding academic achievement.     

Flow,Diversity, Form,and Influence of Political Talk in Social‐Media‐Based Public Forums

By investigating social‐media‐based public forums and using network and content analyses, this study explores how political discussions flow, how diverse they are, and what forms of political discussions are influential. The results suggest that the flow of political discussions is not notably centralized and cliquish. Participants refer primarily to the remarks of like‐minded fellow citizens. Political discussions are more emotional than cognitive and express more anger than anxiety, but it appears that cognitive discussions are more influential than emotional ones. Among cognitive components, assertive and strong discussions have greater influence than analytical ones. These results have implications for the practice of citizenship and the theory of selective exposure as well as for future directions in political communication research.     

A preliminary examination of the evocative effects of the establishing operation

We attempted to isolate the evocative effects of the establishing operation for positively reinforced problem behavior with 2 participants. The study consisted of three phases. First, a functional analysis identified tangible items (Participant 1) and attention (Participant 2) as maintaining problem behavior. Second, access to tangible items and attention was systematically controlled (continuous access vs. no access) immediately prior to functional analysis sessions in which these consequences were delivered contingent on problem behavior. Results of this phase indicated that problem behavior occurred at higher levels when access to tangible items and attention was restricted. In the third phase, prior access was again controlled, but problem behavior produced no consequences. Results of this final phase indicated that problem behavior occurred at higher levels during extinction sessions when participants did not have prior access to the reinforcers.