Predictors of short-term treatment outcome in bulimia nervosa inpatients.

Recent studies, mostly performed on bulimic outpatients, did not find consistent predictors of treatment outcome in bulimia nervosa. This is the first study to investigate anamnestic and clinical factors predictive of the short-term outcome of hospital treatment in 31 female bulimia nervosa patients with a mean age of 22.9 yr. Treatment outcome was assessed by several self-rating instruments measuring different features of the specific and unspecific psychopathology of bulimia nervosa. The most relevant predictors of the outcome of the 8-week hospital treatment were duration of previous inpatient treatments for bulimia, the intensity of anorexic tendency and the pretreatment level of depression. The majority of predictors tested did not show a strong relationship to treatment outcome. The findings are discussed in relation to results of other studies as well as to possible implications for treatment and research.     

Quantitative scores of normal and abnormal subjects on Initial-letter Word-association Test.

The quotient of the mean quantitative score on Initial-letter Word-association Test for 193 normal subjects was significantly higher than the quotient of the mean quantitative score of 44 abnormal (psychotic) subjects. This is interpreted as meaning that, in general, the normal subjects have predominantly a positive attitude towards their surrounding world in contradistinction to the abnormal subjects whose attitude was predominantly negative, ambivalent, and repressive. On the other hand, the mean of the quotients of the quantitative scores of the 44 abnormal subjects was higher than the mean of the quotients of the quantitative scores of the normal subjects which suggests increased oral tendencies of the abnormal subjects expressed much as the unwarranted optimism of small children.     

Slow alpha in the EEG power spectrum as an indicator for conceptual arousal]

Based on previous findings (B?sel et al., 1990) it was assumed that in concept learning tasks generating on hypotheses on a concept which has to be developed is accompanied by increases of the Alpha 1 power (7.5-10 Hz) in the spontaneous EEG activity. In this study 16 subjects performed five problem solving tasks with similar processing requirements. EEG data were analyzed by means of post hoc comparisons of subjects differing in performance quality. Additionally, four control tasks were employed in which, based on previous studies, variations in the Theta frequency range were expected. An effect in the Alpha 1 frequency band was observed in tasks requiring reconstructive recall or testing the usefulness of an mathematical algorithm. The creation of a rank order or mental map is accompanied by power increases in the lower portions of the Alpha 1 frequency band (7.5-8.5 Hz). Moreover a high amount of controlled variance (eta2 up to 34%) was obtained for this effect. Increases in EEG Theta power, which presumably indicate subjects' component analysis, were found before the subjects recognized parts of geometric figures or before relevant features in the "buddhist monk problem" were discriminated. The dynamics of EEG power over time is in examples of frequency/time plots in a figure, illustrated.     

EMG reactions of mimetic muscles after repeated presentation of pictures with positive, negative and neutral content]

Twenty male subjects (Ss) were repeatedly confronted for five seconds to pictures with positive, negative and neutral valence. During the picture presentation facial EMG-reactions of five mimic muscles (m. frontalis lateralis, m. corrugator supercilii, m. orbicularis oculi, m. zygomaticus major on the right and left side of the face) were recorded. In addition, heart rate was measured. It could be shown that during repeated presentation of pictures with positive valence the m. orbicularis oculi and the m. zygomaticus major on both sides of the face yielded enhanced average EMG-reactions as compared to the repeated presentation of pictures with negative and neutral valence. During presentation of pictures with negative valence the m. frontalis lateralis and the m. corrugator supercilii revealed enhanced EMG-reactions as compared to the repeated presentation of pictures with positive valence. Furthermore, it could be shown that during the repeated presentation of pictures with positive valence those facial muscles which mainly react during confrontation with pictures of positive valence showed a continuous decrease of EMG-activity. Facial muscles which mainly react during the presentation of pictures with negative valence do not show a continuous decrease in EMG-activity during the course of the repeated presentation of pictures with negative valence. Additionally, the EMG-activity of the m. zygomaticus major on the right and lift side of the face do not differ with respect to the mean activity and the time course during confrontation of pictures with positive valence. The m. orbicularis oculi yielded enhanced EMG-reactions during the presentation of pictures with positive valence as compared to both m. zygomaticus major muscles. The present results are discussed with respect to psychobiological theories concerning facial expression.     

Discrimination learning of rotated faces: a Markov analysis of coding and association processes]

30 subjects participated in a discrimination experiment learning face-letter associations under four rotation conditions (45 degrees, 90 degrees, 135 degrees, 180 degrees). Under each condition two thirds of the faces were presented twice, upright and rotated away from the vertical; the remaining faces were presented once, upright or rotated. Learning is described by a joint Markov model: For faces that are presented twice it assumes a separate association and encoding process (two-stage-model), for faces that are presented once it assumes an association process (all-or-none-model). The Markov model fits the data for all four rotation conditions. The angle of rotation does not affect learning for faces that are presented once. For faces that are presented twice it influences both the association and the encoding process. For the angles employed, the effect of rotation can be approximated linearly. The results suggest that the encoding of a rotated face differs increasingly from an upright face as a function of these angles of rotation. This confirms analogous conclusions from mental rotation experiments.     

Associative regulation of Pavlovian fear conditioning: unconditional stimulus intensity, incentive shifts, and latent inhibition.

Conditional stimuli (CS) associated with painful unconditional stimuli (US) produce a naloxone-reversible analgesia. The analgesia serves as a negative-feedback regulation of fear conditioning that can account for the impact of US intensity and CS predictiveness on Pavlovian fear conditioning. In Experiment 1 training under naloxone produced learning curves that approached the same high asymptote despite US intensity. Shifting drug treatment during acquisition had effects that paralleled US intensity shifts. In Experiment 3 naloxone reversed Hall-Pearce (1979) negative transfer using a contextual CS, indicating that conditional analgesia acquired during the CS-weak-footshock phase retards acquisition in the CS-strong-footshock phase. Experiment 5 used a tone CS in both a latent-inhibition and a negative-transfer procedure. Only negative transfer was blocked by naloxone. Therefore, negative transfer but not latent inhibition is mediated by a reduction of US processing.     

The utilization of genetic counselors within a newborn screening program

Genetic counselors have participated in the Michigan Newborn Screening Program on a contractual basis since 1988. Their role includes newborn screening education and training, newborn nursery site visits, and monitoring newborn screening in hospitals. Their impact has been to improve the quality of newborn screening services by reducing errors and increasing completion of data fields on newborn screening cards, improving hospital nursery cooperation and problem solving, and enhancing health department response to specific problems.     

The epidemiology of suicide and attempted suicide

Since more than one century suicides have been registered in national statistics of death causes. They thus furnish one of the few parameters of psychiatrically relevant behaviour by means of which trends, cohort, age-group and period effects can be studied over longer periods. Since the second half of last century, the suicide rates for Swiss males--similar to those found in England and Wales--show a decrease in consecutive birth cohorts up to males born in the decade 1930-1940, and a continued decline in the total trend until about World War II. From then on the suicide rates of males in consecutive birth cohorts have been slowly increasing in the majority of European and North American countries--but not so in Sweden. Opposite to this, the predominantly low rates for females display little change. Further to the considerable differences between nations and the predominance of suicides committed by females in some Asian countries and Cuba, the changes indicate the significance of cultural and economic environmental factors. Typical period effects are mainly the result of changes in conception and conditions of life. In attempted suicide they proceed in a more sensitive and more rapid way and are about ten times higher. Such a period effect showing increases by about 300% in younger age-groups followed by a decline, attaining its peak about 1976, was ascertained in large cities of the Federal Republic of Germany. By the example of the effects of a television serial, the study of causal processes turning collective environmental factors into individual suicidal behaviour, proved that regularities are effective in learning by a process of modelling. Besides, the epidemiological data give essential hints how to treat suicidal behaviour.     

HIV infection: trauma and coping with trauma

The initial results of a German-Swedish research project demonstrate the at times active-resistant and at times passive-resigned approaches of AIDS patients toward their illness.